| 师 帅,李秀文,赵伊婷,常帅军,赵 婷.慢性肾衰竭尿毒症期患者血液透析维持治疗发生重症感染的危险因素及不良心血管事件影响因素分析[J].现代生物医学进展英文版,2024,(14):2666-2671. |
| 慢性肾衰竭尿毒症期患者血液透析维持治疗发生重症感染的危险因素及不良心血管事件影响因素分析 |
| Risk Factors for Severe Infection and Influencing Factors of Adverse Cardiovascular Events in Patients with Chronic Renal Failure and Uremia Undergoing Hemodialysis Maintenance Therapy |
| Received:February 08, 2024 Revised:February 25, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.14.012 |
| 中文关键词: 慢性肾衰竭 尿毒症期 维持性血液透析治疗 重症感染 不良心血管事件 影响因素 |
| 英文关键词: Chronic renal failure Uremic phase Maintenance hemodialysis treatment Severe infection Adverse cardiovascular events Influence factor |
| 基金项目:新疆维吾尔自治区自然科学基金项目(2021D01C435) |
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| 中文摘要: |
| 摘要 目的：探讨慢性肾衰竭尿毒症期患者血液透析维持治疗发生重症感染的危险因素及不良心血管事件影响因素。方法：选取我院2021年10月到2023年10月收治的60例慢性肾衰竭尿毒症期患者作为研究对象，所有患者均采取维持性血液透析治疗。分别依照患者重症感染及不良心血管事件发生人数进行分组。即感染组（n=20），非感染组（n=40）与不良心血管事件组（n=22）、非不良心血管事件组（n=38）。分析所有患者一般临床情况，并以重症感染及不良心血管事件分别作为因变量，纳入logistics回归模型，分析重症感染的及不良心血管事件的独立影响因素。结果：感染组与非感染组患者年龄、合并糖尿病、透析时间、合并心力衰竭、留置静脉导管、血红蛋白、Hs-CRP、血白蛋白、空腹血糖水平对比差异显著（P＜0.05）；年龄、合并糖尿病、留置静脉导、Hs-CRP、空腹血糖为慢性肾衰竭尿毒症期患者血液透析维持治疗发生重症感染的独立危险因素（P<0.05）；不良心血管事件组与非不良心血管事件组患者原发疾病、合并高血压、糖尿病、高脂血症、吸烟史、高磷血症、透析时间、Hs-CRP、LDL-C对比差异显著（P＜0.05）；合并高血压、合并高脂血症、高磷血症、Hs-CRP、透析时间为慢性肾衰竭尿毒症期患者血液透析维持治疗发生不良心血管事的独立危险因素（P<0.05）。结论：年龄、合并糖尿病、留置静脉导、Hs-CRP、空腹血糖为慢性肾衰竭尿毒症期患者血液透析维持治疗发生重症感染的独立危险因素，合并高血压、合并高脂血症、高磷血症、Hs-CRP、透析时间为不良心血管事件的独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the risk factors for severe infection and the influencing factors of adverse cardiovascular events in patients with chronic renal failure in the uremic stage undergoing hemodialysis maintenance therapy. Methods: Sixty patients with chronic renal failure and uremia admitted to our hospital from October 2021 to October 2023 were selected as the study subjects, and all patients received maintenance hemodialysis treatment. Group patients according to the number of severe infections and adverse cardiovascular events. The infection group (n=20), non infection group (n=40), and adverse cardiovascular event group (n=22), non adverse cardiovascular event group (n=38). Analyze the general clinical situation of all patients, with severe infection and adverse cardiovascular events as dependent variables, and incorporate them into a logistic regression model to analyze the independent influencing factors of severe infection and adverse cardiovascular events. Results: There were significant differences in age, diabetes, dialysis time, heart failure, indwelling venous catheter, hemoglobin, Hs CRP, albumin and fasting blood glucose between the infected group and the non infected group (P<0.05); Age, diabetes, indwelling venous catheter, Hs CRP and fasting blood glucose were independent risk factors for severe infection in patients with chronic renal failure in uremic stage undergoing hemodialysis maintenance treatment (P<0.05); There were significant differences in primary disease, hypertension, diabetes, hyperlipidemia, smoking history, hyperphosphatemia, dialysis time, Hs-CRP, LDL-C between the adverse cardiovascular event group and the non adverse cardiovascular event group(P<0.05); Hypertension, hyperlipidemia, hyperphosphatemia, Hs CRP, and dialysis time are independent risk factors for adverse cardiovascular events in patients with chronic renal failure in the uremic stage undergoing hemodialysis maintenance therapy(P<0.05). Conclusion: Age, diabetes, indwelling venous catheter, Hs CRP, and fasting blood glucose are independent risk factors for severe infection in patients with chronic renal failure in uremic stage undergoing hemodialysis maintenance treatment. Hypertension, hyperlipidemia, hyperphosphatemia, Hs CRP, and dialysis time are independent risk factors for adverse cardiovascular events. |
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