| 邵丹卉,单燕丽,赵童童,韩秋峪,孙礼强.血清pro-ADM、Galectin-3联合TLR-4对未足月胎膜早破孕妇亚临床绒毛膜羊膜炎的预测价值[J].现代生物医学进展英文版,2024,(13):2532-2536. |
| 血清pro-ADM、Galectin-3联合TLR-4对未足月胎膜早破孕妇亚临床绒毛膜羊膜炎的预测价值 |
| Predictive Value of Serum pro-ADM, Galectin-3 Combined with TLR-4 for Histological Chorioamnionitis in Pregnant Women with Preterm Premature Rupture of the Membrane |
| Received:January 09, 2024 Revised:January 31, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.13.025 |
| 中文关键词: pro-ADM Galectin-3 TLR-4 未足月胎膜早破 亚临床绒毛膜羊膜炎 预测价值 |
| 英文关键词: pro-ADM Galectin-3 TLR-4 Preterm premature rupture of the membrane Histological chorioamnionitis Predictive value |
| 基金项目:江苏省妇幼健康科研项目（F202002） |
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| 中文摘要: |
| 摘要 目的：分析血清肾上腺髓质素前体（pro-ADM）、半乳糖凝集素-3（Galectin-3）联合Toll样受体4（TLR-4）对未足月胎膜早破（PPROM）孕妇亚临床绒毛膜羊膜炎（HCA）的预测价值。方法：研究纳入徐州医科大学附属医院及新疆伊犁哈萨克自治州友谊医院产科2021年6月1日-2023年6月1日收治PPROM孕妇160例为研究对象，按照PPROM孕妇产后胎盘病理结果划分为HCA组（n=71）与非HCA组（n=89），使用酶联免疫吸附法检测孕妇血清pro-ADM、Galectin-3、TLR-4水平，采用单因素与多因素Logistic分析组间发生HCA的相关因素，作受试者工作特征曲线（ROC）曲线分析模型预测价值。结果：单因素分析结果显示：HCA组经产妇、剖宫产比例高于非HCA组，血清PCT、CRP、pro-ADM、Galectin-3、TLR-4水平高于非HCA组（P<0.05）；经过Logistic回归分析发现，PCT、CRP、pro-ADM、Galectin-3、TLR-4是PPROM孕妇HCA发生的独立危险因素（P<0.05）；建立PPROM孕妇HCA影响因素之诊断效能的ROC分析模型，pro-ADM、Galectin-3、TLR-4三项指标独立及联合预测时曲线下面积（AUC）分别为0.720、0.743、0.790、0.874，显见联合应用诊断效能更高。结论：血清pro-ADM、Galectin-3、TLR-4水平升高提示PPROM孕妇HCA发生风险升高，三项联合对PPROM孕妇HCA疾病中预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the predictive value of adrenal-adrenomedullin precursor (pro-ADM), galectin-3 (Galectin-3) and Toll-like receptor 4 (TLR-4) for histological chorioamnionitis (HCA) in pregnant women with preterm premature rupture of the membrane (PPROM). Methods: The study included 160 pregnant women with PPROM who were admitted to the obstetrics department of The Affiliated Hospital of Xuzhou Medical University and Friendship Hospital of Xinjiang Ili Kazakh Autonomous Prefecture from June 1, 2021 to June 1, 2023 as the research subjects. According to the pathological results of postpartum placenta in PPROM pregnant women, they were divided into HCA group (n=71) and non-HCA group (n=89). The levels of serum pro-ADM, Galectin-3 and TLR-4 in pregnant women were detected by enzyme-linked immunosorbent assay, the related factors of HCA between groups were analyzed by univariate and multivariate Logistic analysis, and the predictive value of the model were analyzed by receiver operating characteristic curve(ROC) curve. Results: The results of univariate analysis showed that, the proportion of multipara and cesarean section in HCA group was higher than that in non-HCA group, and the levels of serum PCT, CRP, pro-ADM, Galectin-3 and TLR-4 were higher than those in non-HCA group (P<0.05). Logistic regression analysis showed that, PCT, CRP, pro-ADM, Galectin-3 and TLR-4 were independent risk factors for HCA in pregnant women with PPROM(P<0.05). The ROC analysis model of the diagnostic efficiency of the influencing factors of HCA in PPROM pregnant women was established. The area under the curve(AUC) of pro-ADM, Galectin-3 and TLR-4 in independent and combined prediction was 0.720, 0.743, 0.790 and 0.874, the diagnostic efficiency of combined application were higher respectively. Conclusion: The elevated levels of serum pro-ADM, Galectin-3 and TLR-4 suggest an increased risk of HCA in pregnant women with PPROM, and the combination of the three has a higher predictive value for HCA disease in pregnant women with PPROM. |
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