| 童 静,艾尼·艾海提,凯迪丽娅·凯赛尔,艾日法特·艾尼瓦尔,李 娜.脑仿生电刺激联合金纳多注射液治疗突发性耳聋的听阈增益效果及耳蜗功能的影响[J].现代生物医学进展英文版,2024,(13):2492-2495. |
| 脑仿生电刺激联合金纳多注射液治疗突发性耳聋的听阈增益效果及耳蜗功能的影响 |
| The Effect of Brain Biomimetic Electrical Stimulation Combined with Ginaton Injection on Hearing Threshold Gain and Cochlear Function in the Treatment of Sudden Deafness |
| Received:December 23, 2023 Revised:January 18, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.13.017 |
| 中文关键词: 脑仿生电刺激 金纳多注射液 突发性耳聋 听阈增益 耳蜗功能 血流变学 |
| 英文关键词: Brain biomimetic electrical stimulation Ginaton Injection Sudden deafness Hearing threshold gain Cochlear function Hemorheology |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2022D01C326） |
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| 中文摘要: |
| 摘要 目的：探讨脑仿生电刺激联合金纳多注射液治疗突发性耳聋的听阈增益效果及耳蜗功能的影响。方法：选取2020年10月到2023年10月收治的突发性耳聋患者140例，分为观察组与对照组，各70例。对照组患者采取金纳多注射液治疗，观察组采取脑仿生电刺激联合金纳多注射液治疗。对比两组患者临床疗效，治疗前后耳蜗功能及听阈增益情况，抗内皮细胞抗体（AECA）、可溶性血管细胞间黏附因子-1（sVCAM-1）、内皮素（Endothelin，ET）相关血液标志物水平变化及血流变学相关指标变化。结果：与对照组相比，观察组治疗总有效率高（P＜0.05）；治疗前两组患者纯音气导听阈、听力功能缺损分贝数对比无差异（P＞0.05），治疗后两组患者纯音气导听阈、听力功能缺损分贝数均降低，观察组低于对照组，同时观察组听阈值增益值高于对照组（P＜0.05）；治疗前两组患者AECA、sVCAM-1、ET水平对比无差异（P＞0.05），治疗后均降低，观察组低于对照组（P＜0.05）；治疗前两组患者血浆黏度、全血粘度低切变率、全血粘度高切变率对比无明显差异（P＞0.05），治疗后均降低，观察组低于对照组（P＜0.05）。结论：脑仿生电刺激联合金纳多注射液可提升突发性耳聋的治疗效果，改善患者耳蜗功能，提升听阈，且可降低突发性耳聋相关血液标志物AECA、sVCAM-1、ET表达水平，减轻血液高凝状态，值得临床应用推广。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of brain biomimetic electrical stimulation combined with Ginkgo biloba injection on hearing threshold gain and cochlear function in the treatment of sudden deafness. Methods: A total of 140 cases of patients with sudden deafness admitted to our hospital from October 2020 to October 2023 were selected and divided into observation group and matched group, with 70 cases each. The matched group patients received treatment with Ginaton injection, while the observation group received treatment with brain biomimetic electrical stimulation combined with Ginaton injection. Compare the clinical efficacy, cochlear function and hearing threshold gain before and Post-treatment between two groups of patients, as well as changes in anti endothelial cell antibody (AECA), soluble vascular intercellular adhesion factor-1 (sVCAM-1), endothelin (ET) related blood biomarker levels, and hemorheological indicators. Results: The total effective rate of the observation group was higher than that of the matched group(P<0.05); Pretherapy, there was no difference in the pure tone air conduction hearing threshold and decibels of hearing loss between the two groups of patients(P>0.05). Post-treatment, the pure tone air conduction hearing threshold and decibels of hearing loss decreased in both groups, with the observation group being lower than the matched group. At the same time, the gain value of the observation group's hearing threshold was higher than that of the matched group(P<0.05); Pretherapy, there was no difference in the levels of AECA, sVCAM-1, and ET between the two groups of patients(P>0.05). Post-treatment, both groups decreased, with the observation group being lower than the matched group(P<0.05); There was no difference in plasma viscosity and whole blood viscosity between the two groups(P>0.05), which decreased Post-treatment, and the observation group was lower than the matched group(P<0.05). Conclusion: Brain biomimetic electrical stimulation combined with Ginaton injection can enhance the therapeutic effect of sudden deafness, improve cochlear function, increase hearing threshold, and reduce the expression levels of blood markers AECA, sVCAM-1, and ET related to sudden deafness, reducing blood hypercoagulability. It is worth promoting in clinical practice. |
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