| 杨珍芳,刘 慧,郭志娟,吉 茹,靳君华.CMTM4和PD-L1蛋白在胰腺癌组织中的表达及其与临床病理特征的关系[J].现代生物医学进展英文版,2024,(13):2478-2482. |
| CMTM4和PD-L1蛋白在胰腺癌组织中的表达及其与临床病理特征的关系 |
| Expression of CMTM4 and PD-L1 Proteins in Pancreatic Cancer and Their Relationship with Clinicopathological Features |
| Received:February 03, 2024 Revised:February 28, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.13.014 |
| 中文关键词: CMTM4蛋白 PD-L1蛋白 胰腺癌组织 神经侵犯 淋巴结转移 |
| 英文关键词: CMTM4 protein PD-L1 protein Pancreatic cancer tissue Nerve invasion Lymph node metastasis |
| 基金项目:内蒙古自治区高等学校科学研究项目（NJZY21624） |
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| 中文摘要: |
| 摘要 目的：探讨CMTM4和PD-L1蛋白在胰腺癌组织中的表达状况，并分析二者与临床病理特征的关系。方法：收集2016.1月-2020.1我院及内蒙古医科大学附属医院胰腺癌手术标本40例作为实验组，并同时选取癌旁组织作为对照组，采用免疫组化Envision二步法染色检测胰腺癌组织中CMTM4和PD-L1蛋白表达，统计病理特征，CMTM4和PD-L1蛋白在癌组织、癌旁组织中的表达，以及二者与临床病理特征关系。结果：CMTM4主要分布在肿瘤细胞膜和细胞质中，均呈棕褐色或棕黄色颗粒；PD-L1主要分布在肿瘤间质免疫细胞、细胞膜和细胞质中，呈棕褐色或淡黄色。胰腺癌组织CMTM4蛋白、PD-L1蛋白水平明显高于癌旁组织（P<0.05）。与癌旁组织相比，胰腺癌组织CMTM4蛋白、PD-L1蛋白高表达高，CMTM4蛋白、PD-L1蛋白低表达均明显低于癌旁组织（P<0.05）。CMTM4蛋白高表达、PD-L1蛋白高表达的神经侵犯、淋巴结转移的发病率均高于CMTM4蛋白低表达、PD-L1蛋白低表达（P<0.05）；但性别、年龄、肿瘤部位、肿瘤直径、组织分化程度、TNM分期，CMTM4蛋白高表达、PD-L1蛋白高表达与CMTM4蛋白低表达、PD-L1蛋白低表达比较（P＞0.05）。CMTM4蛋白、PD-L1蛋白表达与胰腺癌的组织分化程度、TNM分期无关（P＞0.05）。结论：CMTM4和PD-L1蛋白在胰腺癌组织中呈高表达，其与神经侵犯、淋巴结转移相关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the expression status of CMTM 4 and PD-L1 protein in pancreatic cancer tissues and analyzed the relationship between the clinician and clinicopathological features. Methods: From January 2016 to 2020.1, our Hospital of Inner Mongolia Medical University collected 40 cases as the experimental group, and selected adjacent tissues as the control group, to detect the expression of CMTM 4 and PD-L1 protein by immunohistochemistry Envision, the expression of CMTM 4 and PD-L1 protein in cancer tissues and adjacent tissues, and the relationship between the two and clinical pathological features. Results: CMTM 4 is mainly distributed in tumor cell membrane and cytoplasm, both brown or brown particles; PD-L1 is mainly distributed in tumor stromal immune cells, cell membrane and cytoplasm, brown or light yellow. The levels of CMTM 4 and PD-L1 in pancreatic cancer were higher than those in adjacent cancer (P<0.05). Compared with adjacent tissues, pancreatic cancer tissues had high expression of CMTM 4 protein and PD-L1 protein, and low expression of CMTM 4 protein and PD-L1 protein was lower than adjacent tissues(P<0.05). The incidence of nerve invasion with high PD-L1 expression and lymph node metastasis was higher than that of CMTM 4 and PD-L1 expression (P<0.05); however, gender, age, tumor site, tumor diameter, tissue differentiation, TNM stage, high CMTM 4 expression and high PD-L1 protein expression and low CMTM 4 protein and low PD-L1 expression (P>0.05). CMTM 4 protein and PD-L1 protein expression were not correlated with the degree of tissue differentiation or TNM stage of pancreatic cancer(P>0.05). Conclusion: CMTM4 and PD-L1 proteins are highly expressed in pancreatic cancer tissues, which are related to nerve invasion and lymph node metastasis. |
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