| 陶靖文,肖兴雷,刘尚仑,陈国庆,曹 辰.小针刀联合关节腔注射PRP对膝骨关节炎患者疼痛介质、血液流变学和骨代谢指标的影响[J].现代生物医学进展英文版,2024,(12):2383-2386. |
| 小针刀联合关节腔注射PRP对膝骨关节炎患者疼痛介质、血液流变学和骨代谢指标的影响 |
| Effects of Small Needle Knife Combined with Intra-Articular Injection of PRP on Pain Mediators, Hemorheology and Bone Metabolism Indexes in Patients with Knee Osteoarthritis |
| Received:January 21, 2024 Revised:February 16, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.12.036 |
| 中文关键词: 小针刀 富血小板血浆 膝骨关节炎 疼痛介质 血液流变学 骨代谢 |
| 英文关键词: Small needle knife Platelet-rich plasma Knee osteoarthritis Pain mediators Hemorheology Bone metabolism |
| 基金项目:江苏省卫生健康委医学科研项目（M2021058） |
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| 中文摘要: |
| 摘要 目的：观察膝骨关节炎患者经关节腔注射富血小板血浆（PRP）和小针刀治疗后其疼痛介质、血液流变学和骨代谢指标的变化情况。方法：按照随机数字表法，将112例膝骨关节炎患者分为对照组（56例，经关节腔注射PRP治疗）和研究组（56例，对照组的基础上接受小针刀治疗）。对比两组疗效、量表评分、疼痛介质、血液流变学、骨代谢指标以及治疗期间不良反应发生情况。结果：研究组的临床总有效率较对照组更高（P<0.05）。研究组治疗后疼痛视觉模拟评分（VAS）和血清P物质（SP）、5羟色胺（5-HT）、前列腺素E2（PGE2）、抗酒石酸盐酸性磷酸酶异构体-5b（TRACP-5b）水平以及红细胞聚集指数、全血黏度低切、血浆黏度、全血黏度高切较对照组更低（P<0.05）。纽约特种外科医院膝关节评分（HSS）评分、Lysholm评分和血清骨特异性碱性磷酸酶（BALP）、骨钙素（BGP）水平较对照组更高（P<0.05）。两组均未见明显的不良反应发生。结论：小针刀联合关节腔注射PRP治疗膝骨关节炎患者，可促进膝关节功能恢复，可能与有效调节疼痛介质、血液流变学和骨代谢指标有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the changes of pain mediators, hemorheology and bone metabolism indexes in patients with knee osteoarthritis after intra-articular injection of platelet-rich plasma (PRP) and small needle knife. Methods: According to the random number table method, 112 patients with knee osteoarthritis were divided into control group (56 cases, intra-articular injection of PRP treatment) and study group (56 cases, small needle knife treatment on the basis of control group). The curative effect, scale score, pain mediators, hemorheology, bone metabolism indexs and adverse reactions during treatment were compared between two groups. Results: The total clinical effective rate in study group was higher than that in control group (P<0.05). The visual analogue scale (VAS) and serum levels of substance P (SP), 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), tartrate-resistant acid phosphatase isomer-5b (TRACP-5b), erythrocyte aggregation index, whole blood viscosity low shear, plasma viscosity and whole blood viscosity high shear in study group were lower than those in control group after treatment (P<0.05). The New York hospital for special surgery knee score (HSS) score, Lysholm score and serum bone-specific alkaline phosphatase (BALP) and osteocalcin (BGP) levels were higher than those in control group(P<0.05). No obvious adverse reactions occurred in two groups. Conclusion: Small needle knife combined with intra-articular injection of PRP can promote the recovery of knee joint function in patients with knee osteoarthritis, which may be relate to the effective regulation of pain mediators, hemorheology and bone metabolism indexs. |
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