| 郑畹玉,黄 甡,刘 宁,李金洋,石欣欣.暖脐散神阙贴敷联合艾灸治疗脾虚型泄泻患儿效果及对肠道微生态的影响[J].现代生物医学进展英文版,2024,(12):2298-2301. |
| 暖脐散神阙贴敷联合艾灸治疗脾虚型泄泻患儿效果及对肠道微生态的影响 |
| Effect of Nuangqi Sanshenque Patch Combined with Moxibustion on Children with Splenic Deficiency Ddiarrhea and Its Influence on Intestinal Microecology |
| Received:November 08, 2023 Revised:November 30, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.12.018 |
| 中文关键词: 泄泻 脾虚型 暖脐散神阙贴敷 艾灸 肠道微生态 |
| 英文关键词: Diarrhea Spleen deficiency type Warm umbilical powder Shenque paste Moxibustion Intestinal microecology |
| 基金项目:河南省中医药科学研究专项课题（2021JDZY032） |
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| 中文摘要: |
| 摘要 目的：分析暖脐散神阙贴敷联合艾灸治疗脾虚型泄泻患儿效果及对肠道微生态的影响。方法：选择河南中医药大学第一附属医院自2021年1月至2022年7月接诊的120例脾虚型泄泻患儿，随机分为对照组和观察组，各60例。对照组予以双歧杆菌三联活菌肠溶胶囊、蒙脱石散治疗；观察组在对照组治疗的基础上，加用暖脐散神阙贴敷联合艾灸治疗，其中艾灸取穴：神阙、中脘、足三里、天枢、脾俞、肾俞，治疗14 d。记录两组患儿症状缓解情况（大便性状正常时间、泄泻停止时间），检测治疗前后肠道屏障功能指标（二胺氧化酶、D-乳酸）、肠道菌群数量（双歧杆菌、乳酸杆菌、粪球菌、大肠杆菌）、血清炎症因子（白介素-6、白介素-8、肿瘤坏死因子α）。结果：对比对照组，观察组大便性状正常时间、泄泻停止时间均更短（P＜0.05）；治疗后，观察组血清二胺氧化酶、D-乳酸水平均低于对照组（P＜0.05）；治疗后，对比对照组，观察组血清白介素-6、白介素-8、肿瘤坏死因子α水平更低（P＜0.05）；治疗后，对比对照组，观察组双歧杆菌、乳酸杆菌的数量更多，粪球菌、大肠杆菌数量更少（P＜0.05）；观察组总有效率为93.33%，对比对照组的83.33%（P＜0.05）。结论：暖脐散神阙贴敷联合艾灸治疗脾虚型泄泻患儿效果显著，有助于缩短病程、改善肠道屏障功能和肠道微生态。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the effect of Nuangqi Sanshenque patch combined with moxibustion on children with splenic deficiency diarrhea and its influence on intestinal microecology. Methods: 120 children with spleen deficiency diarrhea admitted to The First Affiliated Hospital of Henan University of Chinese Medicine from January 2022 to July 2023 were randomly divided into control group and observation group, 60 cases in each group. The control group was treated with bifidum triple viable bacteria capsule and montmorillonite powder; On the basis of the control group, the observation group was treated with warm umbilical Sanshenque patch combined with moxibustion. The moxibustion points were Shenque, Zhongwan, Zusanli, Tianshu, Pishu and Shenshu for 14 days. Symptom relief (normal time of stool traits and stop time of diarrhea) of the children in the two groups were recorded, and intestinal barrier function indexes (diamine oxidase, D-lactic acid), intestinal flora number (bifidobacterium, lactobacillus, fecal coccus, Escoli), serum inflammatory factors(interleukin-6, interleukin-8, tumor necrosis factor α) before and after treatment were detected. Results: Compared the control group, the observation group shit character normal time and diarrhea stop time are shorter(P<0.05). After treatment, the observation group of serum diamine oxidase, D-lactic acid levels are lower than the control group(P<0.05). After treatment, compared to control group and observation group serum interleukin 6 and interleukin 8, tumor necrosis factor alpha levels are lower (P<0.05). After treatment,compared to control group and observation group more the number of bifidobacterium, lactobacillus, less number of dung aureus, escherichia coli(P<0.05). Observation group total effective rate is 93.33%, compared to 83.33% of the control group(P<0.05). Conclusion: Nuanqi Sanshenque patch combined with moxibustion is effective in the treatment of children with splenic deficiency diarrhea, which is helpful to shorten the course of disease, improve intestinal barrier function and intestinal microecology. |
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