| 魏献蒙,白 桥,李 晶,温鹏远,李 瑾.参松养心胶囊联合胺碘酮对心力衰竭后室性心律失常患者的应用效果及对心率变异性影响[J].现代生物医学进展英文版,2024,(11):2094-2098. |
| 参松养心胶囊联合胺碘酮对心力衰竭后室性心律失常患者的应用效果及对心率变异性影响 |
| Effect of Shensong Yangxin Capsule Combined with Amiodarone on Heart Rate Variability in Patients with Ventricular Arrhythmia after Heart Failure |
| Received:January 12, 2024 Revised:January 31, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.11.017 |
| 中文关键词: 参松养心胶囊 胺碘酮 心率变异性 心力衰竭后室性心律失常 应用效果 |
| 英文关键词: Shensong Yangxin capsule Amiodarone Heart rate variability Ventricular arrhythmia after heart failure Application effect |
| 基金项目:国家自然科学基金面上项目（81570273） |
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| 中文摘要: |
| 摘要 目的：探讨对心力衰竭后室性心律失常患者应用参松养心胶囊联合胺碘酮进行治疗的效果。方法：选择150例心力衰竭后室性心律失常，根据随机数字表法，将150例患者分为A组、B组、C组，每组50例。所有患者均行常规抗心力衰竭治疗，A组患者给予参松养心胶囊治疗，B组患者给予胺碘酮片治疗；C组给予胺碘酮片联合参松养心胶囊治疗。对比三组的疗效，对比三组治疗前后的心功能指标、24 h动态心电图指标、心率变异性指数，对比三组治疗过程中的不良反应发生情况。结果：C组治疗有效率明显较A组、B组高（P<0.05），A组、B组间对比无统计学意义（P>0.05）。与治疗前相比，A、B、C三组的LVDs、LVDd降低，LVEF、CO、SV明显升高，且C组较A、B组比较有相同趋势（P<0.05）；A组与B组间对比无统计学意义（P>0.05）。与治疗前相比，A、B、C三组的室性心动过速数量、室性早搏数量、QTd明显降低，QTc升高，且C组较A、B组比较有相同趋势（P<0.05）；A组与B组间对比无统计学意义（P>0.05）。三组不良反应发生率比较无差异（P>0.05）。结论：与单独应用参松养心胶囊、胺碘酮相比，参松养心胶囊联合胺碘酮会提高疗效，且应用安全，可能与其可改善患者的心率变异性有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of sunsong Yangxin capsule combined with amiodarone in patients with ventricular arrhythmia after heart failure. Methods: One hundred and fifty ventricular arrhythmias after heart failure were selected, and 150 patients were divided into groups A, B, and C with 50 patients in each group. All patients received routine anti-heart failure treatment, group A patients were given Shensong Yangxin capsule treatment, group B patients were given amiodarone tablet treatment; Group C was treated with amiodarone tablet combined with Shensong Yangxin capsule. The efficacy of the three groups was compared, and the cardiac function index, 24 h dynamic electrocardiogram index and heart rate variability index before and after treatment were compared, and the occurrence of adverse reactions during treatment was compared between the three groups. Results: The treatment effective rate of group C was significantly higher thanthe other groups (P<0.05), but there was no statistical significance between group A and group B (P>0.05). Moreover, groups A, B, and C had decreased LVDs, increased LVEF, CO, and SV and showed the same trend compared with Group A and B (P<0.05); there was no significant comparison between group A and B (P>0.05). Compared with before treatment, the number of ventricular tachycardia, QTd, ventricular beats, increased QTc, and the same trend in group A and C compared with group A and B (P<0.05); there was no significant comparison between group A and B (P>0.05). There was no difference in the incidence of adverse reactions between the three groups (P>0.05). Conclusion: Compared with shinsong Yangxin capsule and amiodarone alone, shinsong Yangxin capsule combined with amiodarone will improve the efficacy and safe application, which may be related to the improvement of heart rate variability in patients. |
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