| 孙 鹏,张国华,陈超斌,刘 彬,陈 美,周一林,丁 凡.血清Irisin、SOST、H2S与膝骨关节炎合并骨质疏松症患者骨密度、骨代谢标志物的相关性及其预测价值[J].现代生物医学进展英文版,2024,(10):1980-1984. |
| 血清Irisin、SOST、H2S与膝骨关节炎合并骨质疏松症患者骨密度、骨代谢标志物的相关性及其预测价值 |
| Correlation and Predictive Value of Serum Irisin, SOST and H2S with Bone Density and Bone Metabolism Markers in Patients with Knee Osteoarthritis Combined with Osteoporosis |
| Received:October 05, 2023 Revised:October 27, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.10.037 |
| 中文关键词: 膝骨关节炎 骨质疏松症 Irisin SOST H2S 骨密度 骨代谢 相关性 预测价值 |
| 英文关键词: Knee osteoarthritis Osteoporosis Irisin SOST H2S Bone density Bone metabolism Correlation Predictive value |
| 基金项目:湖北省卫生健康委员会联合基金项目（WJ2019H430）；武汉市医学科研项目（WX19B07） |
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| 中文摘要: |
| 摘要 目的：探讨血清鸢尾素（Irisin）、骨硬化蛋白（SOST）、硫化氢（H2S）与膝骨关节炎（KOA）合并骨质疏松症（OP）患者骨密度、骨代谢标志物的相关性，分析Irisin、SOST、H2S预测KOA合并OP的价值。方法：选取2020年4月至2023年4月我院收治的179例KOA患者，根据是否合并OP将其分为OP组（68例）和非OP组（111例）。检测血清Irisin、SOST、H2S和骨代谢标志物骨钙素（OC）、骨碱性磷酸酶（BALP）、Ⅰ型原胶原N-端前肽（PINP）、抗酒石酸酸性磷酸酶异体（TRACP5b）水平，股骨颈、腰椎L1～4骨密度。Pearson分析血清Irisin、SOST、H2S与股骨颈、腰椎L1～4骨密度和血清骨代谢标志物的相关性，受试者工作特征（ROC）曲线分析血清Irisin、SOST、H2S对KOA合并OP的预测价值。结果：OP组血清Irisin、H2S、OC、BALP、PINP水平，股骨颈、腰椎L1～4骨密度低于非OP组（P＜0.05），TRACP、SOST水平高于非OP组（P＜0.05）。OP组血清Irisin、H2S水平与股骨颈、腰椎L1～4骨密度，血清OC、BALP、PINP水平呈正相关（P＜0.05），与血清TRACP水平呈负相关（P＜0.05）；SOST水平与股骨颈、腰椎L1～4骨密度，血清OC、BALP、PINP水平呈负相关（P＜0.05），与血清TRACP水平呈正相关（P＜0.05）。Irisin、SOST、H2S预测KOA合并OP的曲线下面积为0.784、0.773、0.755，联合预测KOA合并OP的曲线下面积为0.908，高于单独预测。结论：KOA合并OP患者血清Irisin、H2S水平降低、SOST水平增高，低水平Irisin、H2S和高水平SOST与骨密度降低、骨代谢异常有关，可用于预测KOA合并OP患者骨代谢异常状态和骨质流失风险。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between serum irisin (Irisin), sclerostin (SOST), hydrogen sulfide (H2S) and bone density and bone metabolism markers in patients with knee osteoarthritis (KOA) combined with osteoporosis (OP), and to analyze the predictive value of Irisin, SOST, and H2S for KOA complicated with OP. Methods: 179 KOA patients who were admitted to our hospital from April 2020 to April 2023 were selected, and patients were divided into OP group (68 cases) and non-OP group (111 cases) according to whether they were combine with OP. The levels of serum Irisin, SOST, H2S and bone metabolism markers osteocalcin (OC), bone alkaline phosphatase(BALP), type I procollagen N-terminal propeptide(PINP), tartrate-resistant acid phosphatase allogenic (TRACP5b), bone density of femoral neck and lumbar spine L1～4 were detected. The correlation between serum Irisin, SOST, H2S and bone density of femoral neck and lumbar spine L1～4 and serum bone metabolic markers were analyzed by Pearson, the predictive value of serum Irisin, SOST and H2S for KOA combine with OP were analyzed by receiver operating characteristic(ROC) curve. Results: The levels of serum Irisin, H2S, OC, BALP and PINP, bone density of femoral neck and lumbar spine L1～4 in OP group were lower than those in non-OP group (P<0.05), while the levels of TRACP and SOST were higher than those in non-OP group(P<0.05). Serum Irisin and H2S levels in OP group were positively correlated with bone density of femoral neck and lumbar spine L1～4, serum OC, BALP and PINP levels (P<0.05), and negatively correlated with serum TRACP level (P<0.05). SOST level was negatively correlated with bone density of femoral neck and lumbar spine L1～4, serum OC, BALP and PINP levels(P<0.05), and positively correlated with serum TRACP level(P<0.05). The area under the curve of Irisin, SOST and H2S in predicting KOA combined with OP was 0.784, 0.773 and 0.755 respectively, the area under the curve of combined prediction of KOA combine with OP was 0.908, which was higher than that of single prediction. Conclusion: Serum Irisin and H2S levels decreased and SOST levels increased in patients with KOA combined with OP. Low levels of Irisin, H2S and high levels of SOST are associated with decreased bone mineral density and abnormal bone metabolism, which can be used to predict abnormal bone metabolism and risk of bone loss in patients with KOA combine with OP. |
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