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| 血浆HPL、INH-A、Klotho与早发型重度子痫前期患者胎儿生长受限的关系研究 |
| Relationship between plasma HPL, INH-A, Klotho and fetal growth restriction in patients with early-onset severe preeclampsia |
| 投稿时间：2024-09-09 修订日期：2024-09-09 |
| DOI： |
| 中文关键词: 早发型重度子痫前期 胎儿生长受限 人胎盘泌乳素 抑制素-A 抗衰老蛋白 |
| 英文关键词: Early onset severe preeclampsia Fetal growth restriction Human placental prolactin Statin A Klotho |
| 基金项目:基金课题：福建省医学创新课题项目 ( 2017-CXB-31 ) |
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| 中文摘要: |
| 目的 探讨血浆人胎盘泌乳素（HPL）、抑制素-A（INH-A）、抗衰老蛋白（Klotho）与早发型重度子痫前期患者胎儿生长受限（FGR）的关系。方法 选取2021年1月至2023年12月我院妇产科收治的127例早发型重度子痫前期患者，根据是否发生FGR分为FGR组（52例）和非FGR组（75例）。检测HPL、INH-A、Klotho水平，使用单因素和多因素Logistic回归分析早发型重度子痫前期患者FGR的影响因素，受试者工作特征（ROC）分析HPL、INH-A、Klotho预测早发型重度子痫前期患者FGR的价值。结果 FGR组血浆HPL、Klotho水平低于非FGR组（P＜0.05），INH-A水平高于非FGR组（P＜0.05）。母体营养不良、24 h蛋白尿、INH-A水平增高是早发型重度子痫前期患者发生FGR的危险因素（P＜0.05），HPL、Klotho水平增高是保护因素（P＜0.05）。HPL、INH-A、Klotho预测早发型重度子痫前期患者发生FGR的曲线下面积分别为0.838、0.827、0.848，联合预测曲线下面积为0.945，高于单独预测。结论 早发型重度子痫前期患者发生FGR可能与血浆HPL、Klotho水平降低，INH-A水平增高有关，联合HPL、INH-A、Klotho可有效预测患者发生FGR的风险。 |
| 英文摘要: |
| Objective To investigate the relationship between human placental prolactin (HPL), statin A (INH-A), Anti-aging protein(Klotho) and fetal growth restriction (FGR) in patients with early-onset severe preeclampsia. Methods 127 patients with early-onset severe preeclampsia admitted to the Obstetrics and gynecology department of our hospital from January 2021 to December 2023 were recruited and divided into FGR group (52 cases) and non-FGR group (75 cases) according to whether FGR occurred. The plasma levels of HPL, INH-A and Klotho were detected, the factors of FGR in patients with early-onset severe preeclampsia were analyzed by multivariate Logistic regression, and the value of HPL, INH-A and Klotho in predicting FGR in patients with early-onset severe preeclampsia was analyzed by ROC. Results The plasma HPL and Klotho levels in FGR group were lower than those in non-FGR group (P < 0.05), and the plasma INH-A levels in FGR group were higher than those in non-FGR group (P < 0.05). Maternal malnutrition, 24 h proteinuria and increased INH-A levels were risk factors for FGR in patients with early-onset severe preeclampsia (P < 0.05), and increased HPL and Klotho levels were protective factors (P < 0.05). The area under the curve predicted by HPL, INH-A and Klotho for the occurrence of FGR in patients with early-onset severe preeclampsia was 0.838, 0.827 and 0.848, and the area under the curve of combined prediction was 0.945, which was higher than that predicted by alone. Conclusion The occurrence of FGR in patients with early-onset severe preeclampsia may be related to the decrease of plasma HPL and Klotho levels and the increase of INH-A levels. The combination of HPL, INH-A and Klotho can predict the risk of FGR efficaciously. |
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