| 王静芬,翟佳佳,马楼艳,李 娅,张 赟,吕雅丽.影响2型糖尿病患者血浆Aβ水平的多因素分析[J].现代生物医学进展英文版,2024,(9):1692-1697. |
| 影响2型糖尿病患者血浆Aβ水平的多因素分析 |
| Multivariate Analysis of Plasma Aβ Levels Affecting Patients with Type 2 Diabetes Mellitus |
| Received:November 05, 2023 Revised:November 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.09.018 |
| 中文关键词: β-淀粉样蛋白 2型糖尿病 多因素分析 |
| 英文关键词: β-amyloid Type 2 diabetes mellitus Multivariate analysis |
| 基金项目:陕西省社会发展项目计划（2020SF-160）；西安交通大学基本科研业务费（自由与探索项目-教师类）（xzy012020057）；西安市人民医院（西安市第四医院）科研孵化基金资助课题（FZ-37）；西安市卫生健康委员会科研项目（2022ms12） |
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| 中文摘要: |
| 摘要 目的：探讨影响2型糖尿病（T2DM）患者的血浆β-淀粉样蛋白（Aβ）水平的相关因素。方法：选取西安市第九医院内分泌科、老年病科住院的T2DM患者415例。另选取年龄、性别、受教育程度、大血管疾病史（心脏病史）相匹配，无糖尿病，并符合排除标准的患者176例为对照组（NC组）。使用ELISA检测血浆Aβ40、Aβ42水平，采用Pearson相关分析评估血糖与血浆Aβ40和Aβ42水平的相关性，多元线性回归分析法评估Aβ40和Aβ42水平影响因素。结果：与NC组比较，T2DM组的患者空腹血糖（FBG）、糖化血红蛋白（HbA1c）、甘油三酯（TG）水平显著升高（P<0.05），高密度脂蛋白（HDL）和低密度脂蛋白（LDL）水平显著降低（P＜0.05）；血浆Aβ40水平明显升高（P=0.002），但血浆Aβ42水平明显降低（P<0.001）。与认知功能正常的T2DM患者相比，伴有认知功能异常的T2DM患者血浆Aβ42水平显著降低（P=0.025）。T2DM患者FBG与血浆Aβ42水平呈负相关（r =-0.099，P=0.016）；多元线性回归分析显示： HDL和TG水平是影响血浆Aβ40含量的因素（P=0.002，P=0.027），也影响血浆Aβ42含量（P=0.004）。结论：T2DM患者血浆Aβ40水平明显升高，而血浆Aβ42水平明显降低，伴有认知功能异常的T2DM患者血浆Aβ42水平明显降低。HDL和TG水平是影响血浆Aβ水平的因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the factors affecting plasma β-amyloid (Aβ) level in patients with type 2 diabetes mellitus (T2DM). Methods: 415 patients with T2DM who were hospitalized in the Department of Endocrinology and Geriatrics of the Ninth Hospital of Xi'an were selected. Another 176 patients matched for age, gender, education level, history of macrovascular disease (history of heart disease), without diabetes, and meeting the exclusion criteria were selected as the control group (NC group). Plasma Aβ40 and Aβ42 levels were measured using ELISA, and the correlation between blood glucose and plasma Aβ40 and Aβ42 levels was assessed by Pearson correlation analysis, and the factors affecting Aβ40 and Aβ42 levels were assessed by Multivariate linear regression analysis. Results: Compared with the NC group, patients in the T2DM group had significantly higher levels of fasting blood glucose (FBG), glycated hemoglobin (HbA1c) and triglyceride (TG) (P<0.05), and significantly lower levels of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) (P<0.05); plasma Aβ40 levels were significantly higher (P=0.002), but plasma Aβ42 levels were significantly lower (P<0.001). Plasma Aβ42 levels were significantly lower in T2DM patients with cognitive abnormalities compared with T2DM patients with normal cognitive function (P=0.025); FBG was negatively correlated with plasma Aβ42 levels in T2DM patients (r=-0.099, P=0.016); and multiple linear regression analyses showed that HDL and TG levels were the factors influencing plasma Aβ40 levels (P=0.002, P=0.027) and also affected plasma Aβ42 levels (P=0.004). Conclusion: Plasma Aβ40 levels were significantly higher and plasma Aβ42 levels were significantly lower in patients with T2DM. Plasma Aβ42 levels were significantly lower in T2DM patients with concomitant cognitive abnormalities. HDL and TG levels are factors that influence plasma Aβ levels. |
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