| 张 婷,王晓欣,张 婵,霍军丽,苏 慧.衰弱对老年类风湿关节炎患者焦虑抑郁、免疫功能和认知功能的影响[J].现代生物医学进展英文版,2024,(9):1658-1661. |
| 衰弱对老年类风湿关节炎患者焦虑抑郁、免疫功能和认知功能的影响 |
| Effects of Frailty on Anxiety and Depression, Immune Function and Cognitive Function in Elderly Patients with Rheumatoid Arthritis |
| Received:November 12, 2023 Revised:December 07, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.09.011 |
| 中文关键词: 衰弱 老年 类风湿关节炎 焦虑抑郁 免疫功能 认知功能 |
| 英文关键词: Frailty Elderly Rheumatoid arthritis Anxiety and depression Immune function Cognitive function |
| 基金项目:陕西省自然科学基础研究计划项目（2019ZY-CXPT-03-01） |
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| 中文摘要: |
| 摘要 目的：观察衰弱对老年类风湿关节炎（RA）患者焦虑抑郁、免疫功能和认知功能的影响。方法：选取2019年1月至2021年12月我院收治的138例RA患者，根据是否发生衰弱将患者分为衰弱组和非衰弱组。对比衰弱组、非衰弱组的焦虑抑郁评分、免疫功能相关指标和认知功能评分变化情况。结果：138例老年RA患者有91例存在衰弱，47例无衰弱。根据是否衰弱将患者分为衰弱组（n=91）和非衰弱组（n=47）。衰弱组的焦虑自评量表（SAS）、抑郁自评量表（SDS）评分高于非衰弱组（P<0.05）。衰弱组的CD3+、CD4+、CD4+/CD8+低于非衰弱组，CD8+高于非衰弱组（P<0.05）。衰弱组的简易精神状态评估量表（MMSE）评分、蒙特利尔认知评估量表（MoCA）评分低于非衰弱组（P<0.05）。结论：衰弱可以增加老年RA患者的焦虑抑郁程度，还可导致免疫功能和认知功能下降。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of frailty on anxiety and depression, immune function and cognitive function in elderly patients with rheumatoid arthritis (RA). Methods: 138 RA patients who were admitted to our hospital from January 2019 to December 2021 were selected, and patients were divided into frailty group and non-frailty group according to whether frailty occurred. The changes of anxiety and depression scores, immune function related indicators and cognitive function scores in frailty group and non-frailty group were compared. Results: Among 138 elderly RA patients, 91 had frailty, and 47 had no frailty. Patients were divided into frailty group (n=91) and non-frailty group (n=47) according to whether they were frail or not. The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in frailty group were higher than those in non-frailty group(P<0.05). CD3+, CD4+ and CD4+/CD8+ in frailty group were lower than those in non-frailty group, and CD8+ was higher than that in non-frailty group (P<0.05). The Mini-Mental State Examination (MMSE) score and Montreal Cognitive Assessment (MoCA) score in frailty group were lower than those in non-frailty group (P<0.05). Conclusion: Frailty can increase the degree of anxiety and depression in elderly RA patients, and can also lead to a decline in immune function and cognitive function. |
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