| 万凤凤,赵 凯,马晓娇,郭 波,李 阳.乙酰半胱氨酸联合万古霉素治疗小儿肺炎效果及对患儿康复指标、潮气呼吸指标的影响[J].现代生物医学进展英文版,2024,(8):1566-1570. |
| 乙酰半胱氨酸联合万古霉素治疗小儿肺炎效果及对患儿康复指标、潮气呼吸指标的影响 |
| The Effect of Acetylcysteine Combined with Vancomycin in the Treatment of Pediatric Pneumonia and Its Impact on Rehabilitation Indicators and Tidal Breathing Indicators of Pediatric Patients |
| Received:September 18, 2023 Revised:October 13, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.08.032 |
| 中文关键词: 小儿肺炎 乙酰半胱氨酸 万古霉素 康复指标 潮气呼吸指标 |
| 英文关键词: Pediatric pneumonia Acetylcysteine Vancomycin Rehabilitation indicators Tidal breathing indicators |
| 基金项目:陕西省保健学会药学服务科研基金项目（KY-2023-01-YX-023） |
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| 中文摘要: |
| 摘要 目的：探讨乙酰半胱氨酸联合万古霉素治疗小儿肺炎的效果以及对患儿康复指标、潮气呼吸指标的影响。方法：选入我院2020年5月~2023年5月收治的肺炎患儿110例，根据治疗方法不同分为对照组和观察组，各55例，分别采用万古霉素治疗和联合使用乙酰半胱氨酸治疗。对比两组的临床疗效、主要症状（发热、咳嗽、肺啰音）消失时间、胸腔炎症吸收时间、潮气呼吸指标[潮气量（VT）、达峰时间比（TPTEF/TE）、达峰容积比（VPEF/VE）和呼吸频率（RR）]、血清炎症因子[C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、降钙素原（PCT）]和不良反应等。结果：观察组主要症状消失时间、胸腔炎症吸收时间较对照组少（P<0.05）。两组患儿治疗后VT、TPTEF/TE、VPEF/VE显著升高，RR及血清CRP、TNF-α、IL-6、PCT水平显著下降（P<0.05）。观察组患儿治疗后VT、TPTEF/TE、VPEF/VE较对照组高，RR及血清CRP、TNF-α、IL-6、PCT水平较对照组低（P<0.05）。观察组患儿愈显率显著高于对照组（94.55% vs. 78.18%，P＜0.05），总有效率（100.00% vs. 96.36%）和不良反应发生率（10.91% vs. 9.09%）与对照组无显著差异（P＞0.05）。结论：乙酰半胱氨酸联合万古霉素治疗小儿肺炎具有较高疗效，可改善患儿潮气呼吸指标、减轻机体炎症反应，加快症状体征缓解，且安全性良好。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficacy of acetylcysteine combined with vancomycin in the treatment of pediatric pneumonia and its impact on rehabilitation indicators and tidal breathing indicators in pediatric patients. Methods: 110 children with pneumonia admitted to our hospital from May 2020 to May 2023 were selected and divided into a matched group and an observation group based on different treatment methods, with 55 cases in each group. They were treated with vancomycin and combined with acetylcysteine, respectively. The clinical efficacy, disappearance time of main symptoms (fever, cough, lung rale), absorption time of thoracic inflammation, and tidal breathing indicators [tidal volume (VT), peak to peak time ratio (TPTEF/TE), peak to volume ratio (VPEF/VE), and respiratory rate (RR)] Serum inflammatory factors such as C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT), and adverse reactions were compared between the two groups. Results: The disappearance time of main symptoms such as fever, cough, lung rales, and the absorption time of chest inflammation in the observation group were shorter than those in the matched group (P<0.05). After treatment, VT, TPTEF/TE, VPEF/VE increased in both groups of children, while RR and serum CRP, TNF, IL-6, and PCT levels significantly decreased (P<0.05). After treatment, the VT, TPTEF/TE, VPEF/VE levels of the observation group were higher than those of the matched group, while the RR and serum CRP, TNF, IL-6, and PCT levels were lower than those of the matched group (P<0.05). The recovery rate of the observation group was higher than that of the matched group (94.55% vs. 78.18%, P<0.05), and the total effective rate (100.00% vs. 96.36%) and incidence of adverse reactions (10.91% vs. 9.09%) were not different from the matched group (P>0.05). Conclusion: Acetylcysteine combined with vancomycin has a high therapeutic effect on pediatric pneumonia, which can improve the tidal and respiratory indicators of children, reduce the inflammatory response of the body, accelerate the relief of symptoms and signs, and have good safety. |
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