| 杨 迪,刘 丹,蔡 波,葛建行,刘彩梅.超声剪切波成像联合白细胞介素-10及趋化因子受体7对甲状腺病变性质的评估价值[J].现代生物医学进展英文版,2024,(8):1520-1524. |
| 超声剪切波成像联合白细胞介素-10及趋化因子受体7对甲状腺病变性质的评估价值 |
| Value of Ultrasonic Shear Wave Imaging Combined with Interleukin-10 and Chemokine Receptor 7 in Evaluating the Lesion Nature of Thyroid Diseases |
| Received:September 16, 2023 Revised:October 12, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.08.023 |
| 中文关键词: 甲状腺疾病 剪切波弹性成像 IL-10 CXCR7 病变性质 评估模型 |
| 英文关键词: Thyroid diseases Shear wave elastic imaging IL-10 CXCR7 Lesion nature Evaluation model |
| 基金项目:吉林省科技发展计划项目（20140520021JH） |
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| 中文摘要: |
| 摘要 目的：探讨超声剪切波成像（2D-SWE）联合白细胞介素-10（IL-10）及趋化因子受体7（CXCR7）对甲状腺病变性质的评估价值。方法：选取2022年1月-2023年10月行甲状腺手术治疗的甲状腺患者89例，对所有患者行术前2D-SWE检查，术后病理组织IL-10及CXCR7表达检测；探讨2D-SWE杨氏模量指标E Mean 、E Max 、IL-10及CXCR7表达与甲状腺病变性质的关系。建立2D-SWE结合IL-10及CXCR7对甲状腺病变性质预测的二元Logistic回归风险评估模型，接收者工作特征曲线（ROC）分析回归模型的评估效能。结果：89个甲状腺病灶中，良性病灶54例，恶性病变35例，IL-10阳性表达33例，CXCR7阳性表达33例。以病理检查结果为金标准，根据病灶性质将病变分为良性病变组（n=54）和恶性病变组（n=35）。恶性病变组2D-SWE杨氏模量指标E Mean 、E Max 高于良性病变组，IL-10、CXCR7阳性表达率高于良性病变组（P＜0.05）。E Mean 、E Max 、IL-10、CXCR7四指标构建的回归风险评估模型对甲状腺病变性质评估价值的曲线下面积（AUC）（0.95CI）为0.854（0.723～0.982），截断值为0.225。结论：2D-SWE杨氏模量指标E Mean 、E Max 、IL-10及CXCR7阳性表达率的升高与甲状腺病变性质密切相关，2D-SWE结合IL-10及CXCR7对甲状腺疾病良恶性具有一定的鉴别价值。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the lesion nature of thyroid diseases with combination of ultrasonic shear wave imaging (2D-SWE) and interleukin-10 (IL-10) and chemokine receptor 7 (CXCR7). Methods: A total of 89 thyroid patients who underwent thyroid surgery from January 2022 to October 2023 were selected. Preoperative 2D-SWE examination was performed in all patients, and the expression of IL-10 and CXCR7 in postoperative pathologic tissues was detected. To explore the relationship between the expression of 2D-SWE Young's modulus indices E Mean , E Max , IL-10 and CXCR7 and the lesion nature of thyroid disease. The risk evaluation model of 2D-SWE combined with IL-10 and CXCR7 to predict the nature of thyroid lesions was established, and the evaluation efficiency of the regression model was analyzed by receiver operating characteristic curve (ROC). Results: Among the 89 thyroid lesions, 54 were benign lesions, 35 were malignant lesions, 33 were IL-10 positive and 33 were CXCR7 positive. Pathological findings were used as the gold standard, and the lesions were divided into benign lesion group (n=54) and malignant lesion group (n=35). The 2D-SWE Young's modulus indices E Mean , E Max in the malignant lesion group were higher than those in the benign lesion group, and the positive expression rates of IL-10 and CXCR7 were higher than those in the benign lesion group (P<0.05). The area under the curve (AUC) (0.95CI) of the regression risk evaluation model constructed by E Mean , E Max , IL-10 and CXCR7 was 0.854 (0.723~0.982), and the cutoff value was 0.225. Conclusion: The increase of 2D-SWE Young's modulus indices E Mean , E Max and IL-10 and CXCR7 positive expression rates is closely related to the nature of thyroid lesions, 2D-SWE combined with IL-10 and CXCR7 has certain value in differentiating benign and malignant thyroid diseases. |
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