| 赖榆芳,陈进杰,老洁慧,艾圣翔,刘 婷.通元针法对肝气郁结型卒中后抑郁患者血清神经营养因子和下丘脑-垂体-肾上腺素轴功能的影响[J].现代生物医学进展英文版,2024,(8):1464-1467. |
| 通元针法对肝气郁结型卒中后抑郁患者血清神经营养因子和下丘脑-垂体-肾上腺素轴功能的影响 |
| Effect of Tongyuan Acupuncture Method on Serum Neurotrophic Factors and Hypothalamic-Pituitary-Adrenal Axis Function in Patients with Post Stroke Depression of Liver Qi Stagnation Type |
| Received:August 06, 2023 Revised:August 31, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.08.011 |
| 中文关键词: 通元针法 肝气郁结型 卒中后抑郁 神经营养因子 下丘脑-垂体-肾上腺素轴功能 |
| 英文关键词: Tongyuan acupuncture method Liver qi stagnation type Post stroke depression Neurotrophic factors Hypothalamic-pituitary-adrenal axis function |
| 基金项目:广东省中医药局科研项目（20181078） |
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| 中文摘要: |
| 摘要 目的：观察通元针法对肝气郁结型卒中后抑郁（PSD）患者血清神经营养因子和下丘脑-垂体-肾上腺素轴功能的影响。方法：按照随机数字表法，将2021年9月-2022年11月期间佛山市中医院收治的PSD患者102例分为对照组（n=51，接受常规治疗）和观察组（n=51，对照组的基础上接受通元针法治疗）。对比两组疗效、抑郁情况、血清神经营养因子和下丘脑-垂体-肾上腺素轴功能指标的变化情况。结果：与对照组相比，观察组的临床总有效率更高（P<0.05）。与对照组治疗4周后、治疗8周后相比，观察组汉密尔顿抑郁量表24项版本（HAMD-24）评分更低（P<0.05）。与对照组治疗8周后相比，观察组血清神经生长因子（NGF）、脑源性神经营养因子（BDNF）、胰岛素样生长因子-1（IGF-1）更高，血浆促肾上腺皮质激素（ACTH）、皮质醇（Cor）、促肾上腺皮质激素释放激素（CRH）更低（P<0.05）。结论：肝气郁结型PSD患者采用通元针法治疗，抑郁症状可得到显著缓解，能够调节血清神经营养因子，改善下丘脑-垂体-肾上腺素轴功能，具有较高的应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effect of Tongyuan acupuncture method on serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function in patients with post stroke depression (PSD) of liver qi stagnation type. Methods: According to the random number table method, 102 PSD patients admitted to Foshan Hospital of Traditional Chinese Medicine from September 2021 to November 2022 were divided into a control group (n=51, receiving routine treatment) and an observation group (n=receiving Tongyuan acupuncture on the basis of the control group). The efficacy, depression and changes of serum neurotrophic factors and hypothalamic-pituitary-adrenal axis function indexes were compared between two groups. Results: Compared with control group, the total clinical effective rate in observation group was higher(P<0.05). Compared with control group 4 weeks after treatment and 8 weeks after treatment, the Hamilton Depression Scale 24 item version (HAMD-24) score in observation group was lower (P<0.05). Compared with control group 8 weeks after treatment, the serum nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and insulin-like growth factor-1 (IGF-1) in observation group were higher, and the plasma adrenocorticotropic hormone (ACTH), cortisol (Cor) and corticotropin releasing hormone (CRH) were lower(P<0.05). Conclusion: PSD patients of liver qi stagnation type are treat with Tongyuan acupuncture method, the depressive symptoms can be significantly alleviate, the serum neurotrophic factors can be regulate, and the function of hypothalamus-pituitary-adrenal axis can be improve, which has high application value. |
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