| 张运如,宁为民,谭 静,李国顺,杨宇航.宣通汤配合高压氧治疗卒中后抑郁效果及对神经功能、心理状态的影响[J].现代生物医学进展英文版,2024,(7):1276-1280. |
| 宣通汤配合高压氧治疗卒中后抑郁效果及对神经功能、心理状态的影响 |
| Effects of Xuantong Tang Combined with Hyperbaric Oxygen on Poststroke Depression and Its Influence on Neurological Function and Psychological State |
| Received:August 25, 2023 Revised:September 21, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.07.014 |
| 中文关键词: 卒中后抑郁 宣通汤 高压氧 神经功能 心理状态 |
| 英文关键词: Post-stroke depression Xuantong Tang High pressure oxygen Neurological function Psychological state |
| 基金项目:广东省基础与应用基础研究基金项目（2021A1515220094） |
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| 中文摘要: |
| 摘要 目的：观察宣通汤配合高压氧治疗卒中后抑郁的疗效及对患者神经功能、心理状态的影响。方法：前瞻性纳入2021年2月至2023年2月期间在本院确诊并接受治疗的82例卒中后抑郁患者，分为对照组和观察组，各41例。对照组患者接受高压氧治疗，观察组患者在对照组基础上加用宣通汤治疗。比较两组患者治疗前后美国国立卫生院卒中量表（NIHSS）评分和汉密尔顿抑郁量表（HAMD）评分以及经颅多普勒超声参数、血清C-反应蛋白（CRP）、同型半胱氨酸（Hcy）和低密度脂蛋白胆固醇（LDL-C）水平。结果：两组患者治疗后NIHSS评分、HAMD评分以及血清CRP、Hcy和LDL-C水平显著低于治疗前，病灶侧椎动脉（VA）、基底动脉（BA）位置血流速度明显高于治疗前（P<0.05）。观察组患者治疗后NIHSS评分、HAMD评分以及血清CRP、Hcy和LDL-C水平显著低于对照组（P<0.05）。观察组患者治疗后病灶侧VA和BA位置血流速度显著高于对照组（P<0.05）。结论：宣通汤配合高压氧能够显著改善卒中后抑郁患者神经功能损伤，缓解抑郁程度，这可能与脑血流速度恢复以及血管内皮损伤因子水平降低有关。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the therapeutic effect of Xuantong Tang combined with hyperbaric oxygen on post stroke depression and its impact on patients' neurological function and psychological state. Methods: 82 patients with post-stroke depression who were diagnosed and treated in our hospital between February 2021 to February 2023 were enrolled prospectively and divided into a control group and an observation group, with 41 patients in each group. The control group received hyperbaric oxygen treatment, while the observation group received Xuantong Tang treatment in addition to the control group. Compare the National Institutes of Health Stroke Scale (NIHSS) and Hamilton Depression Scale (HAMD) scores, as well as transcranial Doppler ultrasound parameters, serum C-reaction protein (CRP), before and after treatment between two groups of patients homocysteine (Hcy) and low density lipoprotein cholesterol (LDL-C) levels. Results: After treatment, the NIHSS score, HAMD score, and serum CRP, Hcy, and LDL-C levels of the two groups of patients were lower than before treatment. The blood flow velocity at the lesion side of the vertebral artery (VA) and basilar artery (BA) was lower than before treatment(P<0.05). After treatment, the NIHSS score, HAMD score, and serum CRP, Hcy, and LDL-C levels in the observation group were lower than those in the control group (P<0.05). After treatment, the blood flow velocity at the VA and BA positions on the lesion side of the observation group was higher than that of the control group(P<0.05). Conclusion: Xuantong Tang combined with hyperbaric oxygen can significantly improve the neurological function damage and alleviate the degree of depression in patients with post-stroke depression, which may be related to the recovery of cerebral blood flow velocity and the decrease of vascular endothelial injury factor levels. |
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