| Objective: To observe the clinical efficacy of auricular buried beans combined with shugan jianpi decoction in the treatment of type 2 diabetes mellitus (T2DM) with depression. Methods: 136 patients with T2DM and depression admitted to Shijiazhuang Hospital of Traditional Chinese Medicine from April 2022 to November 2023 were divided into control group (68 cases, treated with auricular buried beans) and study group (68 cases, treated with shugan jianpi decoction on the basis of control group) by random number table method. The traditional chinese medicine syndrome score, hamilton depression scale (HAMD)-17 score, blood glucose indexes, blood lipid indexes and serum neuroendocrine indexes were compared between two groups. Results: After treatment, 5-hydroxytryptophan (5-HT), dopamine (DA) and high-density lipoprotein cholesterol (HDL-C) in study group were higher than those in control group, and glycosylated hemoglobin (HbAlc), total cholesterol (TC), HAMD-17 score, 2h postprandial blood glucose (2hPG), traditional chinese medicine syndrome score, triglyceride (TG), fasting blood glucose (FPG), adrenocorticotropic hormone (ACTH), low density lipoprotein cholesterol (LDL-C) were lower than those in control group (P<0.05). Conclusion: Auricular buried beans combined with shugan jianpi decoction in the treatment of T2DM patients with depression, which can improve clinical symptoms, may be related to the regulation of glucose and lipid metabolism and serum neuroendocrine. |
