| 王士云,张 娟,高 霞,武传红,成 雅.血清IL-1β、FABP4、STRA6与2型糖尿病合并干眼症的关系研究[J].现代生物医学进展英文版,2024,(6):1086-1090. |
| 血清IL-1β、FABP4、STRA6与2型糖尿病合并干眼症的关系研究 |
| Study on the Relationship between Serum IL-1β, FABP4, STRA6 and Type 2 Diabetes Mellitus Combined with Dry Eye Disease |
| Received:October 11, 2023 Revised:November 07, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.06.015 |
| 中文关键词: 2型糖尿病 IL-1β FABP4 STRA6 干眼症 |
| 英文关键词: Type 2 diabetes mellitus IL-1β FABP4 STRA6 Dry eye disease |
| 基金项目:上海市科技创新行动计划项目（16140900900） |
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| 中文摘要: |
| 摘要 目的：探讨血清白细胞介素-1β（IL-1β）、脂肪酸结合蛋白4（FABP4）、视黄酸诱导基因6（STRA6）与2型糖尿病（T2DM）合并干眼症（DED）的关系。方法：选取2020年6月～2023年6月南京医科大学第四附属医院收治的T2DM合并DED患者129例（T2DM合并DED组）、单纯T2DM患者117例（单纯T2DM组）、85名体检健康志愿者（对照组），根据DED病情程度将T2DM合并DED患者分为轻度组（61例）、中度组（36例）、重度组（32例）。采用酶联免疫吸附法检测血清IL-1β、FABP4、STRA6水平。通过多因素Logistic回归分析T2DM合并DED的影响因素，ROC曲线分析血清IL-1β、FABP4、STRA6水平对T2DM合并DED的预测价值。结果：T2DM合并DED组血清IL-1β、FABP4、STRA6水平高于单纯T2DM组、对照组，单纯T2DM组血清IL-1β、FABP4、STRA6水平高于对照组（P＜0.05）。重度组血清IL-1β、FABP4、STRA6水平高于中度组、轻度组，中度组血清IL-1β、FABP4、STRA6水平高于轻度组（P＜0.05）。多因素Logistic回归分析显示T2DM病程延长和糖化血红白蛋白、IL-1β、FABP4、STRA6升高为T2DM合并DED的独立危险因素，BUT升高为独立保护因素（P＜0.05）。血清IL-1β、FABP4、STRA6水平联合预测T2DM合并DED的曲线下面积为0.916，大于血清IL-1β、FABP4、STRA6水平单独预测的0.784、0.782、0.788。结论：T2DM合并DED患者血清IL-1β、FABP4、STRA6水平升高，是T2DM合并DED的独立危险因素，并且与DED病情严重程度相关。血清IL-1β、FABP4、STRA6联合检测对T2DM合并DED的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum interleukin-1β(IL-1β), fatty acid binding protein 4 (FABP4), stimulated by retinoic acid 6 (STRA6) and type 2 diabetes mellitus (T2DM) combined with dry eye disease (DED). Methods: 129 patients with T2DM combine with DED (T2DM combine with DED group), 117 patients with simple T2DM (simple T2DM group) and 85 healthy volunteers (control group) admitted to The Fourth Affiliated Hospital of Nanjing Medical University from June 2020 to June 2023 were selected, patients with T2DM combine with DED were divided into mild group (61 cases), moderate group (36 cases) and severe group (32 cases) according to the severity of DED. The levels of serum IL-1β, FABP4 and STRA6 were detected by enzyme-linked immunosorbent assay. The influencing factors of T2DM combine with DED were analyzed by multivariate logistic regression analysis, and the predictive value of serum IL-1β, FABP4 and STRA6 levels for T2DM combine with DED were analyzed by ROC curve. Results: The levels of serum IL-1β, FABP4 and STRA6 in T2DM combine with DED group were higher than those in simple T2DM group and control group, and the levels of serum IL-1β, FABP4 and STRA6 in simple T2DM group were higher than those in control group (P<0.05). The levels of serum IL-1β, FABP4 and STRA6 in severe group were higher than those in moderate group and mild group, and the levels of serum IL-1β, FABP4 and STRA6 in moderate group were higher than those in mild group (P<0.05). Multivariate logistic regression analysis showed that prolonged course of T2DM and elevated glycated hemoglobin, IL-1β, FABP4, and STRA6 were independent risk factors for T2DM combine with DED, and elevated BUT was an independent protective factor (P<0.05). The area under the curve of combined prediction of serum IL-1β, FABP4 and STRA6 levels for T2DM combine with DED was 0.916, which was greater than 0.784, 0.782 and 0.788 predicted by serum IL-1β, FABP4 and STRA6 levels alone. Conclusion: The levels of serum IL-1β, FABP4 and STRA6 in patients with T2DM combined with DED are increase, which are independent risk factors for T2DM combine with DED, and are relate to the severity of DED.The combined detection of serum IL-1β, FABP4 and STRA6 has a higher predictive value for T2DM combine with DED. |
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