| 任鲜卉,李 敏,刘丽娟,王金香,康 娟.不同时间窗高压氧治疗对急性脑梗死患者血清ZO-1、Caveolin-1和TLR4/NF-κB信号通路的影响[J].现代生物医学进展英文版,2024,(6):1082-1085. |
| 不同时间窗高压氧治疗对急性脑梗死患者血清ZO-1、Caveolin-1和TLR4/NF-κB信号通路的影响 |
| Effects of Hyperbaric Oxygen Therapy at Different Time Windows on Serum ZO-1, Caveolin-1 and TLR4/NF-?资B Signaling Pathway in Patients with Acute Cerebral Infarction |
| Received:November 08, 2023 Revised:November 30, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.06.014 |
| 中文关键词: 时间窗 高压氧 急性脑梗死 ZO-1 Caveolin-1 TLR4/NF-κB信号通路 |
| 英文关键词: Time window Hyperbaric oxygen Acute cerebral infarction ZO-1 Caveolin-1 TLR4/NF-κB signaling pathway |
| 基金项目:陕西省自然科学基础研究计划（2020JM-338） |
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| 中文摘要: |
| 摘要 目的：探讨不同时间窗高压氧治疗对急性脑梗死（ACI）患者血清紧密连接蛋白（ZO-1）、小窝蛋白-1（Caveolin-1）和Toll样受体4（TLR4）/核转录因子κB（NF-κB）信号通路的影响。方法：选择2020年4月~2023年4月期间在空军军医大学第一附属医院就诊的158例ACI患者作为研究对象，通过随机数字表法分为A组（接受常规治疗，于发病12 h~7 d内接受高压氧治疗）和B组（接受常规治疗，于发病12 h内行高压氧治疗），各79例。对比两组各项量表评分、脑血流灌注、血清ZO-1、Caveolin-1水平和TLR4/NF-κB信号通路相关指标的变化情况。结果：治疗后，B组美国国立卫生研究院卒中量表（NIHSS）低于A组，日常生活活动能力量表（ADL）评分高于A组（P<0.05）。治疗后，B组脑血管储备能力（CVR）、双侧脑动脉峰流速、双侧脑动脉峰平均流速高于A组（P<0.05）。治疗后，B组血清Caveolin-1低于A组，血清ZO-1高于A组（P<0.05）。治疗后，B组TLR4、NF-κB低于A组（P<0.05）。结论：于发病12 h内给予ACI患者高压氧治疗可有效促进神经功能恢复，调节血清ZO-1、Caveolin-1水平，可能与抑制TLR4/NF-κB信号通路激活有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of hyperbaric oxygen therapy at different time windows on serum tight junction protein (ZO-1), caveolin-1 (Caveolin-1) and Toll-like receptor 4 (TLR4)/nuclear transcription factor-κB (NF-κB) signaling pathway in patients with acute cerebral infarction (ACI). Methods: 158 ACI patients who were treated in The First Affiliated Hospital of Air Force Military Medical University from April 2020 to April 2023 were selected as the research objects, patients were divided into group A (accept routine treatment, hyperbaric oxygen therapy was given within 12 h~7 d after the onset of the disease) and group B (accept routine treatment, hyperbaric oxygen therapy was performed within 12 h onset) by random number table method, with 79 cases in each group. The changes of each scale score, cerebral blood perfusion, serum ZO-1, Caveolin-1 levels and TLR4/NF-κB signaling pathway related indicators were compared in two groups. Results: After treatment, the National Institutes of Health Stroke Scale (NIHSS) in group B was lower than that in group A, and the activity of daily living (ADL) score was higher than that in group A(P<0.05). After treatment, the cerebral vascular reserve capacity (CVR), bilateral cerebral artery peak flow velocity and bilateral cerebral artery peak average flow velocity in group B were higher than those in group A (P<0.05). After treatment, serum Caveolin-1 in group B was lower than that in group A, and serum ZO-1 was higher than that in group A(P<0.05). After treatment, TLR4 and NF-κB in group B were lower than those in group A (P<0.05). Conclusion: Hyperbaric oxygen therapy in ACI patients within 12 hours of onset can effectively promote the recovery of neurological function and regulate the levels of serum ZO-1 and Caveolin-1, which may be relate to the inhibition of TLR4/NF-κB signaling pathway activation. |
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