| 李曌洋,李 潇,吴梦瑶,余晓依,周艳艳.消囊调经汤联合达英-35对多囊卵巢综合征患者性激素、脂代谢和卵巢间质血流的影响[J].现代生物医学进展英文版,2024,(5):915-918. |
| 消囊调经汤联合达英-35对多囊卵巢综合征患者性激素、脂代谢和卵巢间质血流的影响 |
| Effects of Xiaonang Tiaojing Decoction Combined with Diane-35 on Sex Hormones, Lipid Metabolism and Ovarian Stromal Blood Flow in Patients with Polycystic Ovary Syndrome |
| Received:August 02, 2023 Revised:August 24, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.05.020 |
| 中文关键词: 消囊调经汤 达英-35 多囊卵巢综合征 性激素 脂代谢 卵巢间质血流 |
| 英文关键词: Xiaonang tiaojing decoction Diane-35 Polycystic ovary syndrome Sex hormone Lipid metabolism Ovarian stromal blood flow |
| 基金项目:河南省科技攻关项目（212102311138） |
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| 中文摘要: |
| 摘要 目的：观察消囊调经汤联合达英-35对多囊卵巢综合征（PCOS）患者性激素、脂代谢和卵巢间质血流的影响。方法：选择2020年7月~2022年12月期间河南省中医院收治的PCOS患者117例。按照随机数字表法分为对照组（达英-35，58例）和研究组（消囊调经汤联合达英-35，59例）。对比两组性激素指标[促黄体生成素（LH）、雌二醇（E2）、促卵泡生成素（FSH）、 睾酮（T）]、中医证候积分、脂代谢[高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、总胆固醇（TC）]和卵巢间质血流情况[子宫动脉搏动指数（PI）、子宫动脉阻力指数（RI）]。结果：研究组治疗后主症积分、次症积分、总积分低于对照组（P<0.05）。研究组治疗后LH、E2、FSH、T低于对照组（P<0.05）。研究组治疗后HDL-C高于对照组；TC、TG、LDL-C低于对照组（P<0.05）。研究组治疗后PI、RI低于对照组（P<0.05）。结论：消囊调经汤联合达英-35治疗PCOS患者，可改善患者的临床症状，调节机体性激素、脂代谢和卵巢间质血流，疗效较好。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of xiaonang tiaojing decoction combined with diane-35 on sex hormones, lipid metabolism and ovarian stromal blood flow in patients with polycystic ovary syndrome (PCOS). Methods: 117 patients with PCOS who were admitted to Henan Provincial Hospital of Traditional Chinese Medicine from July 2020 to December 2022 were selected. Patients were divided into control group (diane-35, 58 cases) and study group (xiaonang tiaojing decoction combined with diane-35, 59 cases) according to the random number table method. The sex hormone indexes [luteinizing hormone (LH), estradiol (E2), follicle stimulating hormone (FSH), testosterone (T)], chinese medicine syndrome scores, lipid metabolism [high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC)] and ovarian stromal blood flow [uterine artery pulsation index (PI), uterine artery resistance index (RI)] were compared between two groups. Results: The main symptom score, secondary symptom score and total score in study group were lower than those in control group after treatment (P<0.05). LH, E2, FSH and T in study group were lower than those in control group after treatment (P<0.05). HDL-C in study group was higher than that in control group; TC, TG and LDL-C were lower than those in control group after treatment (P<0.05). PI and RI in study group were lower than those in control group after treatment (P<0.05). Conclusion: Xiaonang tiaojing decoction combined with diane-35 in the treatment of PCOS patients, which can improve the clinical symptoms of patients, regulate the body's sex hormones, lipid metabolism and ovarian stromal blood flow, and the curative effect is good. |
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