范真真,孙鲁琨,彭 霈,尚明富,谢 倩,钟 萍.康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP的影响[J].现代生物医学进展英文版,2024,(5):882-886. |
康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP的影响 |
Effects of Rehabilitation Training Combined with Hyperbaric Oxygen on Cerebrovascular Dynamics, Vascular Endothelial Function and Serum NSE, UCH-L1 and GFAP in Patients with Hypertensive Cerebral Hemorrhage after Operation |
Received:August 08, 2023 Revised:August 31, 2023 |
DOI:10.13241/j.cnki.pmb.2024.05.014 |
中文关键词: 康复训练 高压氧 高血压脑出血 脑血管动力学 血管内皮功能 NSE UCH-L1 GFAP |
英文关键词: Rehabilitation training Hyperbaric oxygen Hypertensive cerebral hemorrhage Cerebrovascular dynamics Vascular endothelial function NSE UCH-L1 GFAP |
基金项目:国家自然科学基金项目(81801191) |
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中文摘要: |
摘要 目的:观察康复训练联合高压氧对高血压脑出血术后患者脑血管动力学、血管内皮功能和血清神经元特异性烯醇化酶(NSE)、泛素羧基端水解酶(UCH-L1)、神经胶质纤维酸性蛋白(GFAP)的影响。方法:按照随机数字表法将2021年3月~2022年12月我院收治的112例行微创钻孔置管引流术的高血压脑出血术后患者分为对照组(n=56,接受常规康复训练)和观察组(n=56,对照组基础上结合高压氧干预)。对比两组量表评分[日常生活能力量表-改良Barthel指数(MBI)、Fugl-Meyer运动功能评定量表(FMA)、美国国立卫生研究院卒中量表(NIHSS)]、脑血管动力学指标[平均血流量(Qmean)、外周阻力(R)、平均血流速度(Vmean)]、血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)]、血清NSE 、UCH-L1、GFAP水平以及不良反应发生情况。结果:与对照组干预后相比,观察组MBI、FMA评分更高,NIHSS评分更低(P<0.05)。与对照组干预后相比,观察组Vmean、Qmean更高,R更低(P<0.05)。与对照组干预后相比,观察组NSE、UCH-L1、GFAP更低(P<0.05)。与对照组干预后相比,观察组NO更高,ET-1更低(P<0.05)。两组不良反应发生率对比未见差异(P>0.05)。结论:康复训练联合高压氧干预高血压脑出血术后患者,可有效改善脑血管动力学、血管内皮功能和血清NSE、UCH-L1、GFAP水平,减轻神经功能损伤,提高生活自理能力。 |
英文摘要: |
ABSTRACT Objective: To observe the effects of rehabilitation training combined with hyperbaric oxygen on cerebrovascular dynamics, vascular endothelial function and serum neuron specific enolase (NSE), ubiquitin carboxyl terminal hydrolase (UCH-L1) and glial fibrillary acidic protein (GFAP) in patients with hypertensive cerebral hemorrhage after operation. Methods: 112 patients with hypertensive intracerebral hemorrhage who underwent minimally invasive drilling and drainage surgery at our hospital from March 2021 to December 2022 were divided into a control group (n=56, receiving routine rehabilitation training) and an observation group (n=56, combining hyperbaric oxygen intervention with the control group) according to the random number table method.The scale scores [activities of daily living scale-modified Barthel index(MBI), Fugl-Meyer motor function rating scale (FMA), National Institutes of Health Stroke Scale (NIHSS)], cerebrovascular dynamics indexes [mean blood flow (Qmean), peripheral resistance (R), mean blood flow velocity (Vmean)], vascular endothelial function [endothelin-1 (ET-1), nitric oxide (NO)], serum NSE, UCH-L1, GFAP levels and adverse reactions were compared between two groups. Results: Compared with control group after intervention, the MBI and FMA scores in observation group were higher, and the NIHSS score was lower (P<0.05). Compared with control group after intervention, the Vmean and Qmean in observation group were higher, and the R was lower (P<0.05). Compared with control group after intervention, NSE, UCH-L1 and GFAP in observation group were lower (P<0.05). Compared with control group after intervention, NO was higher and ET-1 was lower in observation group (P<0.05). There was no difference in the incidence of adverse reactions between two groups (P>0.05). Conclusion: Rehabilitation training combined with hyperbaric oxygen intervention in patients with hypertensive intracerebral hemorrhage after operation, which can effectively improve cerebrovascular dynamics, vascular endothelial function and serum NSE, UCH-L1, GFAP levels, reduce neurological damage, and improve self-care ability. |
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