| 陈佳林,李健球,王素丽,温保强,王 华.血清LRG1、GRP78与急诊脓毒症患者继发急性肺损伤的关系研究[J].现代生物医学进展英文版,2024,(5):863-867. |
| 血清LRG1、GRP78与急诊脓毒症患者继发急性肺损伤的关系研究 |
| Study on the Relationship between Serum LRG1, GRP78 and Secondary Acute Lung Injury in Patients with Emergency Sepsis |
| Received:September 20, 2023 Revised:October 15, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.05.010 |
| 中文关键词: 急诊脓毒症 急性肺损伤 LRG1 GRP78 影响因素 预测价值 |
| 英文关键词: Emergency sepsis Acute lung injury LRG1 GRP78 Influencing factors Predictive value |
| 基金项目:广东省科技厅自筹经费类科技计划项目（20172C0051） |
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| 中文摘要: |
| 摘要 目的：探讨血清富亮氨酸α-2糖蛋白1（LRG1）、葡萄糖调节蛋白78（GRP78）与急诊脓毒症患者继发急性肺损伤（ALI）的关系。方法：选取2021年1月～2022年10月在我院急诊重症监护室（EICU）接受治疗的155例脓毒症患者为观察组，根据是否继发ALI分为ALI组43例和非ALI组112例，另选取同期我院100名体检健康者为对照组。采用酶联免疫吸附试剂盒检测血清LRG1、GRP78水平。通过单因素及多因素Logistic回归分析脓毒症患者继发ALI的影响因素。受试者工作特征（ROC）曲线分析血清LRG1、GRP78水平对脓毒症患者继发ALI的预测价值。结果：与对照组比较，观察组血清LRG1、GRP78水平升高（P＜0.05）。单因素分析显示，急诊脓毒症患者继发ALI与脓毒症分级、EICU时间、机械通气、脓毒症相关器官衰竭评估（SOFA）评分、血乳酸、LRG1、GRP78有关（P<0.05）。多因素Logistic回归分析显示，脓毒性休克、EICU时间延长和SOFO评分、血乳酸、LRG1、GRP78升高为急诊脓毒症患者继发ALI的独立危险因素（P＜0.05）。ROC曲线分析显示，血清LRG1、GRP78水平单独和联合预测急诊脓毒症患者继发ALI的曲线下面积（AUC）分别为0.790、0.782、0.884，二者联合预测的AUC最大。结论：急诊脓毒症患者血清LRG1、GRP78水平升高与继发ALI密切相关，血清LRG1、GRP78水平联合预测急诊脓毒症患者继发ALI的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum leucine-rich alpha-2 glycoprotein 1 (LRG1), glucose-regulated protein 78 (GRP78) and secondary acute lung injury (ALI) in patients with emergency sepsis. Methods: 155 patients with emergency sepsis who were treated in the emergency intensive care unit (EICU) of our hospital from January 2021 to October 2022 were retrospectively selected as observation group, patients were divided into ALI group (43 cases) and non-ALI group (112 cases) according to whether secondary ALI occurred, and 100 healthy subjects in our hospital during the same period were selected as control group. The levels of serum LRG1 and GRP78 were detected by enzyme-linked immunosorbent assay kit. The influencing factors of secondary ALI in patients with emergency sepsis were analyzed by univariate and multivariate logistic regression. The predictive value of serum LRG1 and GRP78 levels for secondary ALI in patients with emergency sepsis were analyzed by receiver operating characteristic (ROC) curve was used to analyze. Results: Compared with control group, the levels of serum LRG1 and GRP78 in observation group were increased (P<0.05). Univariate analysis showed that, ALI secondary to emergency sepsis was related to sepsis grade, EICU time, mechanical ventilation, sepsis-related organ failure assessment (SOFA) score, blood lactic acid, LRG1 and GRP78 (P<0.05). Multivariate logistic regression analysis showed that, septic shock, prolonged EICU time and increased SOFO score, blood lactic acid, LRG1 and GRP78 were independent risk factors for secondary ALI in patients with emergency sepsis (P<0.05). ROC curve analysis showed that, the area under the curve (AUC) of serum LRG1 and GRP78 levels alone and in combination in predicting ALI secondary to emergency sepsis were 0.790, 0.782 and 0.884 respectively, and the AUC of combined prediction was the largest (P<0.05). Conclusion: The increase of serum LRG1 and GRP78 levels in patients with emergency sepsis is closely relate to secondary ALI, and the combination of serum LRG1 and GRP78 levels has a higher value in predicting secondary ALI in patients with emergency sepsis. |
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