| 李文波,崔明亮,常凤军,白 净,马 勋.血清抗凝血酶Ⅲ、血浆单胺氧化酶与急性冠状动脉综合征的关系及对介入手术后近期主要不良心血管事件的预测效能研究[J].现代生物医学进展英文版,2024,(2):299-303. |
| 血清抗凝血酶Ⅲ、血浆单胺氧化酶与急性冠状动脉综合征的关系及对介入手术后近期主要不良心血管事件的预测效能研究 |
| Study of the Relationship between Serum Antithrombin III and Plasma Monoamine Oxidase and Acute Coronary Syndrome and Their Efficacy in Predicting Major Cardiovascular Adverse Events in the Near Future after Interventional Procedures |
| Received:March 25, 2023 Revised:April 21, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.02.018 |
| 中文关键词: 抗凝血酶Ⅲ 单胺氧化酶 急性冠状动脉综合征 |
| 英文关键词: Thrombin-antithrombin Ⅲ complex Monoamine oxidase Acute coronary syndrome |
| 基金项目:陕西省自然科学基础研究计划项目（2020JM-666） |
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| 中文摘要: |
| 摘要 目的：探讨血清抗凝血酶Ⅲ（ATⅢ）、血浆单胺氧化酶（MAO）与急性冠状动脉综合征的关系及对介入手术后近期主要不良心血管事件的预测效能。方法：选取我院2020年1月到2023年1月收治的85例急性冠状动脉综合征患者作为研究对象，依照患者心内科非ST段抬高型急性冠状动脉综合征缺血评估（GRACE）评分对患者进行分组，将GRACE评分＞140分的20例患者分为高危组，将109~140分的30例患者分为中危组，将≤108分的35例患者分为低危组，另选取同期来我院体检的40名健康者作为对照组，对比四组受检者血清ATⅢ、血浆MAO表达水平，分析血清ATⅢ、血浆MAO与急性冠状动脉综合征严重程度的相关性。随后将85例急性冠状动脉综合征PCI术后近期是否发生不良心血管事件（MACE）分为非MACE组（n=64）和MACE组（n=21），对比两组患者临床特征、血清ATⅢ、血浆MAO表达水平，并分析血清ATⅢ、血浆MAO对急性冠状动脉综合征介入手术后近期主要不良心血管事件的预测效能。结果：四组受检者ATⅢ、MAO水平对比差异显著，高危组ATⅢ水平明显低于中危组、低危组和对照组，高危组MAO水平明显高于中危组、低危组和对照组（P＜0.05）；Spearman相关分析结果显示：ATⅢ、MAO与急性冠状动脉综合征严重程度呈正相关，MAO与急性冠状动脉综合征严重程度呈负相关（P＜0.05）；非MACE组与MACE组患者年龄、心功能分级、左室射血分数、TIMI评分、ATⅢ以及MAO表达水平对比差异显著（P＜0.05）；logistic回归分析结果表明：ATⅢ、MAO为急性冠状动脉综合征介入手术后近期主要不良心血管事件的独立危险因素（P＜0.05）。结论：血清ATⅢ、血浆MAO水平与急性冠状动脉综合征严重程度具有明显相关性，且ATⅢ、MAO为急性冠状动脉综合征介入手术后近期主要不良心血管事件的独立危险因素。提示临床上对于ATⅢ降低和MAO升高的急性冠状动脉综合征患者注意及时采取相关措施预防近期不良心血管事件的发生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum antithrombin III (ATIII) and plasma monoamine oxidase (MAO) and acute coronary syndrome and their predictive efficacy for major adverse cardiovascular events in the near future after interventional procedures. Methods: Eighty-five patients with acute coronary syndrome admitted to our hospital from January 2020 to January 2023 were selected as study subjects, and the patients were grouped according to their cardiology non-ST-segment elevation acute coronary syndrome ischemia assessment (GRACE) scores, and 20 patients with GRACE scores >140 were divided into the high-risk group, 30 patients with scores 109-140 were divided into the medium In addition, 40 healthy patients who came to our hospital for physical examination at the same period were selected as the control group, and serum ATIII and plasma MAO expression levels of the four groups were compared, and the correlation between serum ATIII and plasma MAO and the severity of acute coronary syndrome was analyzed. Subsequently, 85 cases with or without recent adverse cardiovascular events (MACE) after PCI for acute coronary syndrome were divided into non-MACE group (n=64) and MACE group (n=21), and the clinical characteristics, serum ATIII and plasma MAO expression levels of the two groups were compared, and the correlation between serum ATIII and plasma MAO on recent major adverse predictive efficacy of cardiovascular events after acute coronary syndrome intervention. Results: There were differences in the levels of AT Ⅲ and MAO among the four groups. The level of AT Ⅲ in the high-risk group was significantly lower than that in the medium-risk group, the low-risk group and the control group, and the level of MAO in the high-risk group was higher than that in the medium-risk group, the low-risk group and the control group (P<0.05); Spearman correlation analysis showed that AT Ⅲ and MAO were positively correlated with the severity of acute coronary syndrome, while MAO was negatively correlated with the severity of acute coronary syndrome (P<0.05); There was no difference between the non-MACE group and the MACE group in terms of age, cardiac function grading, left ventricular ejection fraction, TIMI score, AT Ⅲ and MAO expression level (P<0.05); The results of logistic regression analysis showed that ATIII and MAO were independent risk factors for major adverse cardiovascular events in the near future after interventional procedures for acute coronary syndromes (P<0.05). Conclusion: Serum ATIII and plasma MAO levels were significantly correlated with the severity of acute coronary syndrome, and ATIII and MAO were independent risk factors for recent major adverse cardiovascular events after interventional procedures for acute coronary syndrome. It is suggested that clinically, for patients with acute coronary syndrome with reduced ATIII and elevated MAO, timely measures should be taken to prevent the occurrence of recent adverse cardiovascular events. |
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