| 杨 秀,赛皮耶·阿卜来提,乔梦菲,阿丽娅·吉力力,卢雪玲.维生素D缺乏和2型糖尿病视网膜病变风险度的相关性研究[J].现代生物医学进展英文版,2024,(1):106-110. |
| 维生素D缺乏和2型糖尿病视网膜病变风险度的相关性研究 |
| Correlation Study between Vitamin D Deficiency and Risk of Retinopathy in Type 2 Diabetes |
| Received:March 27, 2023 Revised:April 23, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.01.020 |
| 中文关键词: 维生素D 2型糖尿病 糖尿病视网膜病变 |
| 英文关键词: Vitamin D Type 2 Diabetes Mellitus Diabetic Retinopathy |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2020D03006） |
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| 中文摘要: |
| 摘要 目的：是探讨维生素D缺乏与2型糖尿病（T2DM）患者视网膜病变（DR）发生风险度的关系。方法：选取2020年12月至2022年8月在新疆医科大学第二附属医院内分泌科住院的2型糖尿病患者作为研究对象。将209名患者根据眼底检查分为DR组（n=50）和正常眼底（NDR）组（n=159）。比较各组患者一般资料、实验室检查指标；采用Spearman分析法分析病程、FBG、HbAlC、25(OH)D与DR的相关性，采用Pearson分析居住地（城镇）、与维生素D缺乏、SBP与DR的相关性，采用Logistics回归分析DR发生的影响因素，比较各组患者维生素D缺乏、病程、FBG、HbA1c及25(OH)D对DR的预测价值。结果：DR组的居住地（农村）、FBG、HbA1c、病程等均大于NDR组，25(OH)D水平低于NDR组，DR组维生素D缺乏率大于NDR组，差异有统计学意义（P＜0.05）。Pearson相关性分析结果表明DR与居住地（城镇）呈负相关（P＜0.05），与SBP、维生素D缺乏呈正相关（P＜0.05）；Spearman相关分析表明DR与25(OH)D呈负相关（P＜0.05），与病程、空腹血糖和糖化血红蛋白等呈正相关（P＜0.05）。Logistic回归分析结果显示，维生素D缺乏、病程、FBG、HbA1c为DR的独立危险因素（P＜0.05），维生素D缺乏的T2DM患者DR发病风险是维生素D不缺乏者的22.019倍（OR=22.019，95%CL 2.119~228.771，P＜0.05）。受试者工作特征（ROC）曲线分析显示，病程、FBG、HbA1c、25(OH)D作为联合变量可有效预测DR，ROC曲线下面积为0.924。结论：25(OH)D与DR呈负相关，维生素D缺乏可能与T2DM患者DR的发生有关。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between vitamin D deficiency and the risk of Diabetic retinopathy (DR) in patients with Type 2 diabetes mellitus (T2DM). Methods: Patients with type 2 diabetes mellitus who were hospitalized in the Endocrinology Department of the Second Affiliated Hospital of Xinjiang Medical University from December 2020 to August 2022 were selected as the research objects. According to fundus examination, 209 patients were divided into DR Group (n=50) and non-diabetic retinopathy (NDR) group (n=159). The general data and laboratory examination indexes of patients in each group were compared. Spearman analysis was used to analyze the correlation between the duration of disease, FBG, HbAlC, 25(OH)D and DR. Pearson analysis was used to analyze the correlation between residence (town), vitamin D deficiency, SBP and DR. logistics regression was used to analyze the influencing factors of DR. The predictive value of vitamin D deficiency, disease duration, FBG, HbA1c and 25(OH)D for DR Were compared among the groups. Results: The residence (rural), FBG, HbA1c, and course of disease in the DR Group were higher than those in the NDR group, the 25(OH)D level was lower than that in the NDR group, and the vitamin D deficiency rate in the DR Group was higher than that in the NDR group, and the differences were statistically significant (P<0.05). Pearson correlation analysis showed that DR Was negatively correlated with residence (town) (P<0.05), and positively correlated with SBP and vitamin D deficiency (P<0.05). Spearman correlation analysis showed that DR Was negatively correlated with 25(OH)D(P<0.05), and positively correlated with course of disease, fasting blood glucose and glycosylated hemoglobin(P<0.05). Logistic regression analysis showed that vitamin D deficiency, course of disease, FBG and HbA1c were independent risk factors for DR (P<0.05). The risk of DR In T2DM patients with vitamin D deficiency was 22.019 times higher than that in patients without vitamin D deficiency (OR=22.019, 95%CI 2.119-228.771, P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the duration of diabetes, FBG, HbA1c and 25(OH)D as combined variables could effectively predict DR, and the area under the ROC curve was 0.924. Conclusion: 25(OH)D is negatively correlated with DR, and vitamin D deficiency may be related to the occurrence of DR In T2DM patients. |
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