| 刘 颖,赵丽娜,林 妍,胡欣然,苏春燕,刘 峰,郑 彤,陈 雪,于红建.免疫增强型肠内营养对老年重症肺炎患者营养状态、肺功能及体液免疫指标的影响[J].现代生物医学进展英文版,2024,(1):60-64. |
| 免疫增强型肠内营养对老年重症肺炎患者营养状态、肺功能及体液免疫指标的影响 |
| Effects of Immune Enhanced Enteral Nutrition on Nutritional Status, Lung Function and Humoral Immunity in Elderly Patients with Severe Pneumonia |
| Received:August 17, 2023 Revised:September 13, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.01.010 |
| 中文关键词: 免疫增强型肠内营养 老年 重症肺炎 营养状态 肺功能 体液免疫 |
| 英文关键词: Immune enhanced enteral nutrition Elderly Severe pneumonia Nutritional status Lung function Humoral immunity |
| 基金项目:中国中医科学院科技创新工程（C12021A02907） |
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| 中文摘要: |
| 摘要 目的：探讨免疫增强型肠内营养对老年重症肺炎（SP）患者营养状态、肺功能及体液免疫指标的影响。方法：选取我院2021年1月至2023年1月104例老年SP患者作为研究对象，按随机抽签法随机分为对照组和观察组各52例，对照组采用常规肠内营养支持，观察组采用免疫增强型肠内营养支持。比较两组组患者症状及体征恢复时间，治疗前后的病情严重程度、肺炎严重指数、肺功能、营养状态、体液免疫指标。结果：观察组发热、咳嗽、肺部啰音、X线阴影消失时间短于对照组（P＜0.05）；治疗后观察组急性生理与慢性健康评估（APACHE Ⅱ）评分低于对照组（P＜0.05）；治疗后观察组肺炎危险分级优于对照组（P＜0.05）；治疗后观察组总蛋白（TP）、前白蛋白（PA）、白蛋白（ALB）、转铁蛋白（TRF）水平高于对照组（P＜0.05）；治疗后观察组肺动态顺应性（Cdyn）高于对照组，气道阻力（R）低于对照组（P＜0.05）；治疗后观察组免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）、补体C3、补体C4水平高于对照组（P＜0.05）。结论：免疫增强型肠内营养支持能加速老年SP患者临床症状及体征缓解，改善其病情、肺炎严重程度及肺功能，提升患者的免疫能力和营养水平，有一定临床应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of immune enhanced enteral nutrition on nutritional status, lung function and humoral immunity in elderly patients with severe pneumonia (SP). Methods: 104 elderly SP patients in our hospital from January 2021 to January 2023 were selected as research objects, and were randomly divided into control group and observation group with 52 cases in each group according to random drawing method. The control group received conventional enteral nutrition support, and the observation group received immune enhanced enteral nutrition support. The recovery time of symptoms and signs, severity of disease, pneumonia severity index, lung function, nutritional status, humoral immunity index before and after treatment were compared between the two groups. Results: The disappearance time of fever, cough, lung rales and X-ray shadow in observation group was shorter than that in control group(P<0.05). After treatment, the Acute Physiology and Chronic Health Evaluation Ⅱ(APACHEⅡ) scores of the observation group were lower than those of the control group(P<0.05); After treatment, the risk grade of pneumonia in observation group was better than that in control group(P<0.05). After treatment, the levels of total protein (TP), prealbumin (PA), albumin (ALB) and transferrin (TRF) in observation group were higher than those in control group(P<0.05); After treatment, the dynamic lung compliance (Cdyn) of observation group was higher than that of control group, and airway resistance (R) was lower than that of control group (P<0.05). After treatment, the levels of immunoglobulin A (IgA), immunoglobulin M (IgM), immunoglobulin G (IgG), complement C3 and complement C4 in observation group were higher than those in control group(P<0.05). Conclusion: Immune enhanced enteral nutrition support can accelerate the relief of clinical symptoms and signs in elderly SP patients, improve their condition, pneumonia severity and lung function, and enhance their immune capacity and nutritional level, which has certain clinical application value. |
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