| 陈媛媛,李 娜,李长永,候聪聪,孙继萍.结缔组织病相关间质性肺炎患者血清NLR、PLR以及LDH水平的表达及临床意义[J].现代生物医学进展英文版,2023,(23):4506-4510. |
| 结缔组织病相关间质性肺炎患者血清NLR、PLR以及LDH水平的表达及临床意义 |
| Expression and Clinical Significance of Serum NLR, PLR and LDH Levels in Patients with Connective Tissue Disease Associated Interstitial Lung Disease |
| Received:May 06, 2023 Revised:May 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.23.021 |
| 中文关键词: 结缔组织病相关间质性肺炎 NLR PLR LDH 表达 临床意义 |
| 英文关键词: Connective tissue disease associated interstitial lung disease NLR PLR LDH Expression Clinical significance |
| 基金项目:山东省医药卫生科技发展计划项目（2018WS0647） |
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| 中文摘要: |
| 摘要 目的：研究结缔组织病相关间质性肺炎（CTD-ILD）患者血清中性粒细胞与淋巴细胞计数的比值（NLR）、血小板与淋巴细胞计数的比值（PLR）以及乳酸脱氢酶（LDH）水平的表达及临床意义。方法：选择从2018年1月到2021年1月在中国人民解放军联勤保障部队第九六Ο医院接受治疗的CTD患者155例作为研究对象，根据有无合并间质性肺炎（ILD）分为ILD组、无ILD组。ILD组患者根据不同影像分型分为寻常型ILD（UILD）组、非特异型ILD（NSILD）组、未定型组，根据病变范围分级情况分为Ⅰ级组、Ⅱ级组、Ⅲ级组；根据病情状况分为活动组、非活动组；根据预后分为存活组、死亡组。另选同期在医院接受健康体检的志愿者80例作为对照组，比较各组血清NLR、PLR、LDH、纤维蛋白原（Fib）、第1秒用力呼气容积（FEV1）占预计值的百分比（FEV1%）、用力肺活量（FVC）、以及FEV1/FVC比值。结果：ILD组的血清NLR、PLR、LDH及Fib水平较无ILD组及对照组明显更高，而FVC、FEV1%及FEV1/FVC水平较无ILD组及对照组明显更低（P＜0.05）。无ILD组的血清NLR、PLR、LDH及Fib水平较对照组明显更高，而FVC、FEV1%及FEV1/FVC水平较对照组明显更低（P＜0.05）。不同影像分型患者血清NLR、PLR、LDH、Fib、FVC、FEV1%及FEV1/FVC水平比较，差异不显著（P＞0.05）。Ⅱ级组及Ⅲ级组患者血清NLR、PLR以及LDH水平较Ⅰ级组更高，且Ⅲ级组较Ⅱ级组更高（P＜0.05），而三组Fib、FVC、FEV1%及FEV1/FVC水平比较，差异不显著（P＞0.05）。活动组患者血清NLR、PLR以及LDH水平较非活动组更高（P＜0.05），而Fib、FVC、FEV1%及FEV1/FVC水平比较，差异不显著（P＞0.05）。死亡组患者血清NLR、PLR以及LDH水平较存活组更高（P＜0.05），而Fib、FVC、FEV1%及FEV1/FVC水平比较，差异不显著（P＞0.05）。结论：NLR、PLR以及LDH水平在CTD-ILD患者血清中呈现高表达，且这三项指标有助于较好地评价患者的病情及预后。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of serum neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lactate dehydrogenase (LDH) levels in patients with connective tissue disease associated interstitial lung disease (CTD-ILD). Methods: 155 patients with CTD who were treated in the 960th Hospital of the PLA Joint Logistics Support Force from January 2018 to January 2021 were selected as the study subjects, and they were divide into ILD group and non ILD group based on the presence or absence of interstitial pneumonia (ILD). Patients in ILD group were divided into common type ILD (UILD) group, non-specific type ILD (NSILD) group, and undefined group based on different imaging types, and they were divided into grade I group, grade II group, and grade III group based on the grade of the lesion area. They were divide into active group and inactive group based on the state of the disease. They were divided into survival group and death group based on prognosis. Another 80 volunteers who were underwent health examinations in the hospital during the same period were selected as control group, serum NLR, PLR, LDH, fibrinogen (Fib), percentage of predicted value (FEV1%) of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio were compared in each group. Results: The serum NLR, PLR, LDH, and Fib levels in ILD group were significantly higher than those in non ILD group and control group, the FVC, FEV1%, and FEV1/FVC levels were significantly lower than those in non ILD group and control group (P<0.05). The serum NLR, PLR, LDH, and Fib levels in non ILD group were significantly higher than those in control group, the FVC, FEV1%, and FEV1/FVC levels were significantly lower than those in control group (P<0.05). The serum NLR, PLR, LDH, Fib, FVC, FEV1%, and FEV1/FVC levels in patients with different imaging types were compared, and the difference was not significant (P>0.05). The serum NLR, PLR, and LDH levels in patients in grade II group and grade III group were higher than those in grade I group, and grade III group were higher than those in grade II group (P<0.05), But the Fib, FVC, FEV1%, and FEV1/FVC levels were compared between three groups, and the difference was not significant (P>0.05). The serum NLR, PLR, and LDH levels in active group were higher than those in inactive group (P<0.05), but the Fib, FVC, FEV1% and FEV1/FVC levels were compared, and the difference was not significant (P>0.05). The serum NLR, PLR, and LDH levels in death group were higher than those in survival group (P<0.05), but the Fib, FVC, FEV1% and FEV1/FVC levels were compared, and the difference was not significant (P>0.05). Conclusion: The NLR, PLR, and LDH levels are highly expressed in the serum of patients with CTD-ILD, and which three indicators help to better evaluate the patient's state of the disease and prognosis. |
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