| 李 欣,贾美君,季晶俊,陶丽宇,崔 松.灵景方治疗冠心病PCI术后焦虑状态（心神失养证）的临床疗效观察[J].现代生物医学进展英文版,2023,(23):4450-4454. |
| 灵景方治疗冠心病PCI术后焦虑状态（心神失养证）的临床疗效观察 |
| Clinical Observation on the Effect of Lingjing Fang in Treating Anxiety after PCI in Patients with Coronary Heart Disease |
| Received:April 23, 2023 Revised:May 18, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.23.009 |
| 中文关键词: 冠心病PCI术后 焦虑 灵景方 临床疗效 |
| 英文关键词: Coronary heart disease after PCI Anxiety Lingjing Fang Clinical efficacy |
| 基金项目:2020年度上海市科技计划项目（20DZ2311400）；2020年度上海市卫生健康委科研课题（面上项目）（202040072）；2020年上海市卫生健康委员会中医药科研项目（2020LQ013） |
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| 中文摘要: |
| 摘要 目的：研究中药"灵景方"对冠心病PCI术后焦虑状态（心神失养证）患者的疗效。方法：选取2022年4月至2023年3月期间，上海中医药大学附属曙光医院心血管科的患者者共64例，分为中药治疗组及对照组各32例。对照组予常规西药治疗，中药治疗组在对照组基础上加用中药"灵景方"治疗，疗程2个月，运用汉密尔顿焦虑量表（HAMA）、躯体化症状自评量表（SSS）、中医证候积分等评估治疗前后两组患者的焦虑程度、躯体化症状程度以及中医临床证候的缓解程度，并分析患者治疗前后血清hs-CRP水平，以评估炎症反应程度，进而评价患者远期预后。结果：治疗前，两组患者在一般资料、HAMA评分、SSS评分、中医证候积分、血清hs-CRP等方面均无差异。治疗后HAMA评分的下降在中药治疗组内有差异（P＜0.05），而对照组组内无差异（P＞0.05），治疗后中药治疗组评分低于对照组（P＜0.05）。治疗后两组中医证候积分均有下降（P＜0.05），中药治疗组评分较对照组低（P＜0.05）。中药治疗组的总有效率为72.41%，对照组的总有效率为56.67%，中药治疗组的有效率高于对照组（P＜0.05）。两组患者SSS评分在治疗后均有下降，且中药治疗组评分下降更多（P＜0.01）。两组患者治疗后血清hs-CRP下降，中药治疗组低于对照组（P＜0.05）。结论：灵景方可明显减轻冠心病PCI术后（心神失养型）患者的焦虑情绪、中医临床临床症候及躯体化症状，提高生活质量，降低炎症反应，对冠心病的远期预后可起到积极作用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative effect of Chinese medicine "Ling Jing Fang" on patients with anxiety after PCI of coronary heart disease. Methods: From April 2022 to March 2023, 64 patients in the Department of Cardiology, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine were selected and randomly divided into Chinese medicine treatment group and matched group with 32 patients in each group. The matched group was treated with conventional western medicine, while the Chinese medicine treatment group was treated with Chinese medicine "Ling Jing Fang" on the basis of the matched group. The course of treatment was 2 months. The anxiety, somatization symptoms and the relief of TCM clinical symptoms of the two groups were evaluated by Hamilton Anxiety Scale (HAMA), Somatization Symptoms Checklist (SSS) and TCM Syndrome Integral before and post-treatment, and the serum hs-CRP level before and post-treatment was analyzed to evaluate the degree of inflammatory reaction and further evaluate the long-term prognosis of patients. Results: Pretherapy, there was no difference in general information, HAMA score, SSS score, TCM syndrome score and serum hs-CRP between the two groups, which was comparable. The decrease of HAMA score post-treatment was significant in the Chinese medicine treatment group (P<0.05), but not in the matched group (P>0.05). Post-treatment, the score in the Chinese medicine treatment group was lower than that in the matched group (P<0.05). post-treatment , the scores of TCM syndromes in both groups decreased (P<0.05), and the scores in the TCM treatment group decreased more than those in the matched group (P<0.05). The total effective rate of the Chinese medicine treatment group was 72.41%, while that of the matched group was 56.67%. The effective rate of the Chinese medicine treatment group was higher than that of the matched group (P<0.05). Post-treatment, the SSS scores of both groups decreased (P<0.05), and the scores of the Chinese medicine treatment group decreased even more (P<0.05). The level of serum hs-CRP in the two groups also decreased post-treatment (P<0.05), and the decrease in the Chinese medicine treatment group was greater than that in the matched group (P<0.05). Conclusion: Lingjing recipe can obviously alleviate the anxiety, clinical symptoms of traditional Chinese medicine and somatization symptoms of patients with coronary heart disease after PCI, and improve their quality of life. It can also reduce the inflammatory reaction of patients and play a positive role in the long-term prognosis of coronary heart disease. |
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