| 崔淑节,李 享,章玲群,徐 蒙,邵红霞.参元益气活血胶囊联合心痛贴穴位贴敷对不稳定性心绞痛气虚血瘀证患者脂代谢和氧化应激的影响[J].现代生物医学进展英文版,2023,(23):4446-4449. |
| 参元益气活血胶囊联合心痛贴穴位贴敷对不稳定性心绞痛气虚血瘀证患者脂代谢和氧化应激的影响 |
| Effect of Shenyuan Yiqi Huoxue Capsule Combined with Acupoint Application of Heartache Patch on Lipid Metabolism and Oxidative Stress in Patients with Unstable Angina of Qi Deficiency and Blood Stasis Syndrome |
| Received:June 20, 2023 Revised:July 18, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.23.008 |
| 中文关键词: 参元益气活血胶囊 心痛贴 穴位贴敷 不稳定性心绞痛 气虚血瘀证 脂代谢 氧化应激 |
| 英文关键词: Shenyuan Yiqi Huoxue Capsule Heartache patch Acupoint application Unstable angina Qi deficiency and blood stasis syndrome Lipid metabolism Oxidative stress |
| 基金项目:北京市属医院科研培育计划项目（PZ2017007） |
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| 中文摘要: |
| 摘要 目的：观察参元益气活血胶囊联合心痛贴穴位贴敷对不稳定性心绞痛（UA）气虚血瘀证患者脂代谢和氧化应激的影响。方法：按照随机数字表法将2020年3月~2022年9月期间首都医科大学附属北京中医医院收治的100例UA患者分为对照组（常规西医治疗和心痛贴穴位贴敷）和研究组（对照组的基础上接受参元益气活血胶囊治疗），各为50例。对比两组中医证候积分、心绞痛发作次数和持续时间、脂代谢指标[总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）]、氧化应激指标[超氧化物歧化酶（SOD）、丙二醛（MDA）]、心功能指标[左心室射血分数（LVEF）、心输出量（CO）、左心室舒张末期内径（LVEDD）]。结果：两组治疗4周后胸痛、胸闷、气短、心悸、神倦乏力、自汗、不寐评分均下降，且研究组均低于对照组（P<0.05）。两组治疗4周后心绞痛发作次数减少，持续时间缩短，且研究组改善幅度大于对照组（P<0.05）。两组治疗4周后TG、TC、LDL-C下降，HDL-C升高，且研究组改善幅度大于对照组（P<0.05）。两组治疗4周后SOD升高，MDA下降，且研究组改善幅度大于对照组（P<0.05）。两组治疗4周后LVEF、CO升高，LVEDD下降，且研究组改善幅度大于对照组（P<0.05）。结论：参元益气活血胶囊联合心痛贴穴位贴敷治疗UA气虚血瘀证患者，可减少心绞痛发作次数，缩短持续时间，促进临床症状改善，改善心功能、脂代谢和氧化应激水平。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of Shenyuan Yiqi Huoxue capsule combined with acupoint application of heartache patch on lipid metabolism and oxidative stress in patients with unstable angina (UA) of Qi deficiency and blood stasis syndrome. Methods: 100 patients with UA in Beijing Traditional Chinese Medicine Hospital Affiliated to Capital Medical University from March 2020 to September 2022 were divided into control group (conventional western medicine treatment and heartache paste acupoint application) and study group (received Shen Yuan Yiqi Huoxue capsule treatment on the basis of the control group) according to the random number table method, with 50 cases in each group. The traditional Chinese medicine syndrome scores, number and duration of angina attacks, lipid metabolism indexes [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)], oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA)] and cardiac function indexes [left ventricular ejection fraction (LVEF), cardiac output (CO), left ventricular end-diastolic diameter (LVEDD)] were compared between the two groups. Results: The scores of chest pain, chest tightness, shortness of breath, palpitation, fatigue, spontaneous sweating and insomnia decreased of the two groups 4 weeks after treatment, and the study group was lower than that of the control group (P<0.05). The number of angina decreased and the duration shortened of the two groups 4 weeks after treatment, and the improvement of the study group was greater than that of the control group (P<0.05). TG, TC, LDL-C decreased and HDL-C increased of the two groups 4 weeks after treatment, and the improvement of the study group was greater than that of the control group (P<0.05). SOD increased and MDA decreased of the two groups 4 weeks after treatment, and the improvement of the study group was greater than that of the control group (P<0.05). LVEF and CO increased and LVEDD decreased of the two groups 4 weeks after treatment, and the improvement of the study group was greater than that of the control group (P<0.05). Conclusion: Shenyuan Yiqi Huoxue capsule combine with acupoint application of heartache patch for patients with UA of Qi deficiency and blood stasis syndrome, which can reduce the number of angina attacks, shorten the duration, promote the improvement of the clinical symptoms, improve cardiac function, lipid metabolism and oxidative stress levels. |
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