| 周海燕,单 莉,何菊仙,樊晓慧,王新晓.加减黄芪丹参饮联合优思悦治疗多囊卵巢综合征的效果及对外周血Th17/Treg免疫失衡的影响研究[J].现代生物医学进展英文版,2023,(22):4385-4389. |
| 加减黄芪丹参饮联合优思悦治疗多囊卵巢综合征的效果及对外周血Th17/Treg免疫失衡的影响研究 |
| Study on the Effect of Modified Huangqi Danshen Yin Combined with Yousiyue in the Treatment of Polycystic Ovary Syndrome and its Impact on Peripheral Blood Th17/Treg Immune Imbalance |
| Received:April 18, 2023 Revised:May 12, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.22.037 |
| 中文关键词: 加减黄芪丹参饮 优思悦 多囊卵巢综合征 子宫内膜厚度 最大卵泡直径 Th17/Treg免疫失衡 |
| 英文关键词: Addition and subtraction of Huangqi Danshen Yin Yousiyue Polycystic ovary syndrome Endometrial thickness Maximum follicle diameter Th17/Treg immune imbalance |
| 基金项目:陕西省卫生健康委科研基金项目（2018D039） |
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| 中文摘要: |
| 摘要 目的：探讨与研究加减黄芪丹参饮联合优思悦治疗多囊卵巢综合征的效果及对外周血Th17/Treg免疫失衡的影响。方法：选择2018年7月到2022年1月在本院诊治的多囊卵巢综合征患者66例作为研究对象，根据1:1简单分配原则把患者分为中药组与对照组各33例。对照组给予优思悦治疗，中药组在对照组治疗的基础上给予加减黄芪丹参饮治疗，所有患者都治疗观察3个月经周期，测定与计算外周血Th17/Treg免疫失衡情况。结果：治疗后中药组的总有效率为100.0%，与对照组的81.8%相比明显增高（P<0.05）。两组治疗后的Th17/Treg值都明显低于治疗前（P<0.05），中药组与对照组相比也明显降低（P<0.05）。两组治疗后的子宫内膜厚度与最大卵泡直径都明显高于治疗前（P<0.05），治疗后中药组与对照组相比也明显提高（P<0.05）。两组治疗后的血清雌二醇(E2)含量明显高于治疗前（P<0.05），血清催乳素（PRL）含量明显低于治疗前（P<0.05），治疗后中药组与对照组都有明显差异差异（P<0.05）。结论：加减黄芪丹参饮联合优思悦治疗多囊卵巢综合征能有效调节外周血Th17/Treg免疫失衡，促进性激素分泌正常，提高患者的子宫内膜厚度与最大卵泡直径，提高患者的总体治疗效果。 |
| 英文摘要: |
| ABSTRACT Objective: To explore and study the efficacy of modified Huangqi Danshen Yin combined with Yousiyue in the treatment of polycystic ovary syndrome and its impact on peripheral blood Th17/Treg immune imbalance. Methods: 66 cases of patients with polycystic ovary syndrome who were diagnosed and treated in our hospital from July 2018 to January 2022 were selected as the research subjects. Accordded to the 1:1 simple allocation principle, the patients were divided into the traditional Chinese medicine group and the control group with 33 cases each. The control group were treated with Yousiyue, and the Chinese medicine group were treated with modified Huangqi Danshen Decoction on the basis of the control group. All patients were treated and observed for three Menstrual cycle, and the peripheral blood Th17/Treg immune imbalance were measured and calculated. Results: After treatment, the total effective rate of the traditional Chinese medicine group were 100.0%, which were higher than the control group's 81.8%(P<0.05). The Th17/Treg values after treatment in both groups were lower than before treatment(P<0.05), and the traditional Chinese medicine group also showed a decrease compared to the control group(P<0.05). The endometrial thickness and maximum follicle diameter of the two groups after treatment were higher than before treatment(P<0.05), and the traditional Chinese medicine group also showed a increase compared to the control group after treatment (P<0.05). The content of serum estradiol (E2) after treatment were higher than that before treatment(P<0.05), and the content of serum Prolactin (PRL) were significantly lower than that before treatment(P<0.05). There were difference between the Chinese medicine group and the control group after treatment(P<0.05). Conclusion: The combination of modified Huangqi Danshen Yin and Yousiyue in the treatment of polycystic ovary syndrome can effectively regulate the immune imbalance of peripheral blood Th17/Treg, promote normal secretion of sex hormones, increase the thickness of the patient's endometrium and the maximum follicle diameter, and improve the overall treatment effect of the patient. |
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