| 刘海娜,王 强,何 苗,王 朋,刘 聪,孙源富,杨 烁,王宇峰.NLR、PLR与分化型甲状腺癌术后131I清甲效果的关系及其预测价值分析[J].现代生物医学进展英文版,2023,(22):4354-4358. |
| NLR、PLR与分化型甲状腺癌术后131I清甲效果的关系及其预测价值分析 |
| Relationship and Predictive Value of NLR, PLR with Postoperative 131I Thyroidectomy Efficacy in Differentiated Thyroid Cancer |
| Received:May 04, 2023 Revised:May 25, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.22.031 |
| 中文关键词: 分化型甲状腺癌 甲状腺全切除术 131I清甲治疗 中性粒细胞/淋巴细胞比值 血小板/淋巴细胞比值 |
| 英文关键词: Differentiated thyroid cancer Total thyroidectomy 131I thyroidectomy treatment Neutrophil/lymphocyte ratio Platelet/lymphocyte ratio |
| 基金项目:江苏省青年医学重点人才资助课题（QNRC2016396） |
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| 中文摘要: |
| 摘要 目的：探讨中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）与分化型甲状腺癌（DTC）术后碘131（131I）清甲治疗效果的关系及对DTC术后131I清甲效果的预测价值。方法：选择2019年3月至2021年12月在江苏大学附属徐州医院行甲状腺切除术且术后进行131I清甲治疗的DTC患者150例为研究对象，根据131I清甲治疗效果分为清甲成功组（107例）和清甲未成功组（43例），通过检查血常规获得中性粒细胞计数、血小板计数、淋巴细胞计数并计算NLR、PLR，比较两组NLR、PLR；采用单因素及多因素logistics回归模型分析131I清甲疗效的影响因素，采用受试者工作特征曲线（ROC）分析NLR、PLR对131I清甲治疗效果的预测价值。结果：清甲成功组NLR、PLR低于清甲未成功组（P＜0.05），单因素分析显示清甲成功组促甲状腺激素（TSH）高于清甲未成功组，甲状腺球蛋白（Tg）水平低于清甲未成功组，清甲成功组病灶最大径小于清甲未成功组（P＜0.05）；多因素logistics回归分析显示，高NLR、PLR、Tg是131I清甲治疗失败的独立危险因素（P＜0.05）；NLR、PLR及联合检测预测131I清甲治疗效果的ROC曲线下面积（AUC）分别为0.760、0.732、0.829，NLR与PLR联合检测的AUC高于二者单独检测。结论：高NLR、PLR是DTC术后131I清甲未成功的独立危险因素，早期检测NLR、PLR对DTC术后131I清甲治疗效果具有较好的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the relationship between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and the treatment effect of iodine 131 (131I) thyroidectomy after operation for differentiated thyroid cancer (DTC) and the predictive value of the effect of 131I thyroidectomy after DTC operation. Methods: 150 DTC patients who underwent thyroidectomy and underwent 131I thyroidectomy after operation in Xuzhou Hospital Affiliated to Jiangsu University from March 2019 to December 2021 were selected as the study subjects, and the patients were divided into successful thyroidectomy group (107 cases) and unsuccessful thyroidectomy group (43 cases) according to the effect of 131I thyroidectomy, neutrophil count, platelet count, lymphocyte count were obtained by blood routine examination and NLR and PLR were calculated, and the NLR and PLR were compared between the two groups. The influencing factors of 131I thyroidectomy efficacy was analyzed by single factor and multiple factor logistic regression model, and the predictive value of NLR and PLR on the efficacy of 131I thyroidectomy was analyzed by receiver operating characteristic curve (ROC). Results: The NLR and PLR in the successful thyroidectomy group were lower than those in the unsuccessful thyroidectomy group(P<0.05), single factor analysis showed that the levels of thyroid stimulating hormone (TSH) was higher than that in the unsuccessful thyroidectomy group, thyroglobulin(Tg) in the successful thyroidectomy group was lower than those in the unsuccessful thyroidectomy group, and the maximum diameter of the lesion in the successful thyroidectomy was smaller than that in the unsuccessful thyroidectomy group (P<0.05). Multivariate logistics regression analysis showed that, high NLR, PLR and Tg were independent risk factors for failure of 131I thyroidectomy (P<0.05). The area under ROC curve (AUC) of NLR, PLR and combined detection predicting the efficacy of 131I thyroidectomy was 0.760, 0.732, 0.829 respectively, and the AUC of NLR and PLR combined detection was higher than that of the two alone. Conclusion: High NLR and PLR are independent risk factors for unsuccessful 131I thyroidectomy after DTC operation, and early detection of NLR and PLR levels has good predictive value for the efficacy of 131I thyroidectomy after DTC operation. |
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