| 霍 晶,高琪磊,沈琪琪,蒋慈原,范晓芳.超声造影定量参数联合癌胚抗原、中性粒细胞/淋巴细胞比值对乳腺癌改良根治术后复发转移的预测价值[J].现代生物医学进展英文版,2023,(22):4289-4293. |
| 超声造影定量参数联合癌胚抗原、中性粒细胞/淋巴细胞比值对乳腺癌改良根治术后复发转移的预测价值 |
| Predictive Value of Quantitative Parameters of Contrast-enhanced Ultrasound Combined with Carcinoembryonic Antigen and Neutrophil/lymphocyte Ratio for Recurrence and Metastasis of Breast Cancer after Modified Radical Mastectomy |
| Received:May 06, 2023 Revised:May 30, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.22.018 |
| 中文关键词: 乳腺癌 改良根治术 复发 转移 超声造影 癌胚抗原 中性粒细胞/淋巴细胞比值 |
| 英文关键词: Breast cancer Modified radical mastectomy Recurrence Metastasis Contrast-enhanced ultrasound Carcinoembryonic antigen Neutrophil / lymphocyte ratio |
| 基金项目:江苏省卫生健康委员会科研基金项目（KJ2018043） |
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| 中文摘要: |
| 摘要 目的：探讨超声造影定量参数联合癌胚抗原（CEA）、中性粒细胞/淋巴细胞比值（NLR）对乳腺癌改良根治术后复发转移的预测价值。方法：选择2020年12月至2022年1月我院收治的120例行改良根治术治疗的乳腺癌患者，所有患者均行乳腺超声造影检查获得超声造影特征图像及超声造影定量参数，检测血清CEA水平和NLR，统计术后复发转移的发生情况。受试者工作特征（ROC）曲线分析超声造影定量参数联合CEA、NLR预测乳腺癌改良根治术后复发转移的价值。结果：两组术前超声造影特征比较，复发转移组增强强度略高，大部分为高增强或整体增强，造影剂分布尚均匀。18例术后发生复发转移（复发转移组），复发转移组峰值强度（PI）大于未复发转移组，血清CEA水平和NLR高于未复发转移组，达峰时间（TTP）小于未复发转移组（P＜0.05）。PI、TTP、CEA、NLR预测乳腺癌改良根治术后复发转移的曲线下面积（AUC）为0.693、0.764、0.763、0.781，联合PI、TTP、CEA和NLR预测乳腺癌改良根治术后复发转移的AUC为0.909，大于各指标单独预测。结论：乳腺癌改良根治术后复发转移患者超声造影参数PI增大、TTP降低，血清CEA和NLR增高，联合检测TTP、PI、CEA和NLR在乳腺癌改良根治术后复发转移中具有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of quantitative parameters of contrast-enhanced ultrasound combined with carcinoembryonic antigen (CEA) and neutrophil/lymphocyte ratio (NLR) for recurrence and metastasis of breast cancer after modified radical mastectomy. Methods: 120 patients with breast cancer who underwent modified radical mastectomy in our hospital were selected from December 2020 to January 2022. All patients underwent breast CEUS to obtain contrast-enhanced images and quantitative CEUS parameters. Serum CEA levels and NLR were measured, and the incidence of recurrence and metastasis after surgery were statistically analyzed. The ROC curve of subjects was used to analyze the value of quantitative parameters of contrast-enhanced ultrasound combined with CEA and NLR in predicting the recurrence and metastasis of breast cancer after modified radical mastectomy. Results: Compared the preoperative sonographic features of the two groups, the recurrent metastasis group showed slightly higher enhancement intensity, most of which were hyperenhanced or globally enhanced, and the contrast agent distribution was not yet uniform. The results showed that 18 patients experienced postoperative recurrence and metastasis (in the recurrence and metastasis group). The peak intensity (PI) of the recurrence and metastasis group was higher than that of the non recurrence and metastasis group, and the serum CEA level and NLR were higher than those of the non recurrence and metastasis group. The time to peak (TTP) was lower than that of the non recurrence and metastasis group (P<0.05). The area under the curve (AUC) predicted by PI, TTP, CEA and NLR for recurrence and metastasis of breast cancer after modified radical mastectomy were 0.693, 0.764, 0.763 and 0.781, and the AUC predicted by PI, TTP, CEA and NLR for recurrence and metastasis of breast cancer after modified radical mastectomy was 0.909, which was greater than that predicted by each index alone. Conclusion: In patients with recurrence and metastasis of breast cancer after modified radical mastectomy, contrast-enhanced ultrasound parameters PI increased and TTP decreased, serum CEA and NLR increased. Combined detection of TTP, PI, CEA and NLR has a high predictive value in recurrence and metastasis of breast cancer after modified radical mastectomy. |
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