| 刘亚文,吴 更,孟虹良,何洪立,周 玭.早期开髓减压引流术联合氢氧化钙对牙髓炎患者咀嚼功能及血清CD14、HIF-1α、CX3CL1水平的影响[J].现代生物医学进展英文版,2023,(21):4197-4200. |
| 早期开髓减压引流术联合氢氧化钙对牙髓炎患者咀嚼功能及血清CD14、HIF-1α、CX3CL1水平的影响 |
| Effect of Early Myelotomy Decompression and Drainage Surgery Combined with Calcium Hydroxide on Masticatory Function and Serum CD14, HIF-1α and CX3CL1 Levels in Patients with Pulpitis |
| Received:May 01, 2023 Revised:May 25, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.21.038 |
| 中文关键词: 早期开髓减压引流术 氢氧化钙 牙髓炎 咀嚼功能 CD14 HIF-1α CX3CL1 |
| 英文关键词: Early myelotomy decompression and drainage surgery Calcium hydroxide Pulpitis Masticatory function CD14 HIF-1α CX3CL1 |
| 基金项目:江苏省卫生健康委员会医学科研立项项目（ZDB20210510）；连云港市卫生科技项目面上课题（202011） |
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| 中文摘要: |
| 摘要 目的：探讨氢氧化钙联合早期开髓减压引流术对牙髓炎患者血清白细胞分化抗原-14 （CD14）、缺氧诱导因子-1α（HIF-1α）、CX3C趋化因子配体1（CX3CL1）水平和咀嚼功能的影响。方法：选取2020年1月~2022年4月期间徐州医科大学附属连云港医院收治的174例牙髓炎患者，按照双色球法将患者分为对照组、研究组，各为87例。两组均接受早期开髓减压引流术，对照组使用氧化锌丁香酚水门汀填充，研究组使用氢氧化钙糊剂填充。观察两组疗效、疼痛视觉模拟评分（VAS）、咬合力、咀嚼效率、CD14、HIF-1α、CX3CL1水平。结果：与对照组相比，研究组的临床总有效率进一步升高（P<0.05）。与对照组相比，研究组治疗7 d后VAS评分降低，咬合力增加，咀嚼效率提高， 血清CD14、HIF-1α、CX3CL1水平降低（P<0.05）。结论：牙髓炎早期开髓减压引流术后采用氢氧化钙填充治疗，可有效减轻患者疼痛，改善咀嚼功能，提升咬合力，调节血清CD14、HIF-1α、CX3CL1水平，提高临床治疗效果。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of calcium hydroxide combined with early myelotomy decompression and drainage surgery on serum leukocyte differentiation antigen-14 (CD14), hypoxia inducible factor-1α (HIF-1α) and CX3C chemokine ligand 1 (CX3CL1) levels and masticatory function in patients with pulpitis. Methods: 174 patients with pulpitis who were treated in Lianyungang Hospital affiliated to Xuzhou Medical University were selected from January 2020 to April 2022, the patients were divided into control group and study group according to the double chromosphere method, 87 cases each. Both groups underwent early myelotomy decompression and drainage surgery, the control group was filled with zinc oxide eugenol cement, the study group was filled with calcium hydroxide paste filling. The efficacy, visual analog score of pain (VAS), bite force, chewing efficiency, CD14, HIF-1α and CX3CL1 levels in two groups were observed. Results: Compared with the control group, the clinical total effective rate was further increased in the study group(P<0.05). Compared with the control group, the VAS score decreased, bite force increased, chewing efficiency increased and serum CD14, HIF-1α and CX3CL1 levels decreased in the study group 7 d after treatment(P<0.05). Conclusion: Early pulp opening decompression and drainage of pulpitis was treated with calcium hydroxide filling, can effectively reduce the pain in the patient, improve the chewing function, lift the bite force, regulation of the serum CD14, HIF-1α and CX3CL1 levels, improve the clinical treatment effect. |
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