| 王 岱,何曼曼,李智申,荀军峰,高 素,吴存虎,窦新涛.基于脑肠轴理论探讨健脾化痰方联合针刺对卒中后抑郁患者血清SP、NPY和炎症介质的影响[J].现代生物医学进展英文版,2023,(21):4182-4186. |
| 基于脑肠轴理论探讨健脾化痰方联合针刺对卒中后抑郁患者血清SP、NPY和炎症介质的影响 |
| Exploring the Effect of Jianpi Huatan Fang Combined with Acupuncture on Serum SP, NPY, and Inflammatory Mediators in Poststroke Depression Patients Based on the Brain-gut Axis Theory |
| Received:May 04, 2023 Revised:May 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.21.035 |
| 中文关键词: 脑肠轴理论 健脾化痰方 针刺 卒中后抑郁 P物质 神经肽Y 炎症介质 |
| 英文关键词: Brain-gut axis theory Jianpi Huatan Fang Acupuncture Poststroke depression Substance P Neuropeptide Y Inflammatory mediators |
| 基金项目:河北省中医药管理局科研计划项目（2021270） |
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| 中文摘要: |
| 摘要 目的：基于脑肠轴理论探讨健脾化痰方联合针刺对卒中后抑郁（PSD）患者血清P物质（SP）和神经肽Y（NPY）和炎症介质的影响。方法：研究对象来自石家庄市中医院脑病科2019年3月~2022年4月期间收治的PSD患者，共计116例。按照随机数字表法，将患者分为对照组和实验组，各为58例。基于脑肠轴理论，对照组在接受西医常规治疗的基础上增加健脾化痰方治疗，实验组在对照组的基础上接受针刺治疗。观察两组的疗效、各项量表评分[汉密尔顿抑郁量表（HAMD）、美国国立卫生研究院卒中量表（NIHSS)、日常生活活动能力评分（ADL）]、SP、NPY、炎症介质[白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、高迁移率簇蛋白B1（HMGB1）]。结果：实验组的临床总有效率高于对照组（P<0.05）。实验组治疗后HAMD 、NIHSS评分低于对照组，ADL评分高于对照组（P<0.05）。实验组治疗后SP低于对照组，NPY高于对照组（P<0.05）。实验组治疗后IL-1β、IL-6、TNF-α、HMGB1低于对照组（P<0.05）。结论：基于脑肠轴理论健脾化痰方联合针刺治疗PSD，可以有效改善患者的临床症状，调节血清SP、NPY和炎症介质水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Jianpi Huatan Fang combined with acupuncture on serum substance P (SP) and neuropeptide Y (NPY) and inflammatory mediators in poststroke depression (PSD) patients based on the brain-gut axis theory. Methods: The research subjects were 116 PSD patients admitted to the Department of Encephalopathy of Shijiazhuang Traditional Chinese Medicine Hospital from March 2019 to April 2022.According to the random number table method, the patients were divided into control group and experimental group, with 58 cases each. Both groups were based on the brain-gut axis theory, the control group received conventional western medicine treatment combined with Jianpi Huatan Fang treatment, while the experimental group received acupuncture treatment on the basis of control group. The efficacy, rating of various scales [Hamilton depression scale (HAMD), national institutes of health stroke scale (NIHSS), activity of daily living scale (ADL)], SP, NPY, inflammatory mediators [interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high mobility group protein B1 (HMGB1)] in two groups were observed. Results: The total clinical effective rate in experimental group was higher than that in control group (P<0.05). The HAMD and NIHSS scores in experimental group were lower than those in control group, and the ADL scores was higher than that in control group after treatment (P<0.05). The SP in experimental group was lower than that in control group, and NPY was higher than that in control group after treatment(P<0.05). The IL-1β, IL-6, TNF-α, and HMGB1 in experimental group were lower than those in control group after treatment(P<0.05). Conclusion: Treatment of PSD through Jianpi Huatan Fang combined with acupuncture based on brain-gut axis theory, which can effectively improve the clinical symptoms of patients, regulate the levels of serum SP, NPY, and inflammatory mediators. |
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