| 范青云,江 婷,方朝晖,谈佳佳,孟海雷.七味白术散合补阳还五汤对2型糖尿病患者颈动脉内中膜厚度和胰岛素抵抗的影响[J].现代生物医学进展英文版,2023,(21):4105-4109. |
| 七味白术散合补阳还五汤对2型糖尿病患者颈动脉内中膜厚度和胰岛素抵抗的影响 |
| Effects of Qiwei Baizhu Powder and Buyang Huanwu Decoction on Carotid Intima-media Thickness and Insulin Resistance in Ratients with Type 2 Diabetes |
| Received:May 02, 2023 Revised:May 27, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.21.020 |
| 中文关键词: 2型糖尿病 七味白术散 补阳还五汤 颈动脉内膜中膜厚度 胰岛素抵抗 疗效 |
| 英文关键词: Type 2 diabetes Qiwei Baizhu Powder Buyang Huanwu Tang Carotid artery intima media thickness Insulin resistance Curative effect |
| 基金项目:国家自然科学基金面上项目（8177151780） |
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| 中文摘要: |
| 摘要 目的：评价七味白术散合补阳还五汤对2型糖尿病（T2DM）患者颈动脉内中膜厚度（IMTc）和胰岛素抵抗（IR）的影响。方法：选入我院2020年9月~2022年9月收治的T2DM患者80例，根据治疗方法不同分为常规组（常规基础治疗）和联合组（常规基础治疗+七味白术散合补阳还五汤），各40例。检测两组的血糖、血脂指标，计算IR指数（HOMA-IR），并通过超声测定IMTc。结果：两组治疗后各血糖（FPG和HbA1c）、血脂（TC、TG、LDL-C和HDL-C）指标均较治疗前有不同程度的改善，而联合组改善幅度明显大于常规组（P<0.05）；相较于治疗前，两组治疗后HOMA-IR明显下降、HOMA-?茁显著升高（P<0.05），而联合组下降/升高幅度更大，与常规组差异显著（P<0.05）；治疗前，两组IMTc值无明显差异（P＞0.05），而治疗后，联合组IMTc值显著低于常规组（P<0.05）；联合组治疗总有效率较常规组高（92.50% vs. 72.50%，P<0.05），不良反应发生率较常规组低（2.50% vs. 15.00%，P＜0.05）。结论：七味白术散合补阳还五汤可有效提升T2DM的治疗效果，改善糖脂代谢及?茁细胞功能，减少IR及IMTc值，且不良反应少。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the effect of Qiwei Baizhu Powder and Buyang Huanwu Decoction on carotid intima-media thickness (IMTc) and insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM). Methods: 80 T2DM patients admitted to our hospital from September 2020 to September 2022 were selected and divided into a conventional group (conventional basic treatment) and a combination group (conventional basic treatment+Qiwei Baizhu Powder combined with Buyang Huanwu Tang) based on different treatment methods, with 40 patients in each group. Detect blood glucose and lipid indicators in both groups, calculate IR index (HOMA-IR), and measure IMTc through ultrasound. Results: After treatment, the blood glucose (FPG and HbA1c) and blood lipid (TC, TG, LDL-C, and HDL-C) indicators in both groups showed varying degrees of improvement compared to before treatment, while the improvement in the combined group was significantly greater than that in the conventional group(P<0.05). Compared with before treatment, the two groups showed a significant decrease in HOMA-IR and a significant increase in HOMAβ after treatment(P<0.05), while the decrease/increase amplitude in the combination group was significantly greater than that in the conventional group(P<0.05). Before treatment, there was no significant difference in IMTc values between the two groups(P>0.05), while after treatment, the IMTc values in the combination group were significantly lower than those in the conventional group (P<0.05). The total effective rate of the combined group was significantly higher than that of the conventional group (92.50% vs. 72.50%, P<0.05), and the incidence of adverse reactions was significantly lower than that of the conventional group (2.50% vs. 15.00%, P<0.05). Conclusion: Qiwei Baizhu Powder combined with Buyang Huanwu Tang can effectively enhance the therapeutic effect of T2DM, improve glucose and lipid metabolism, enhance β Cell function, reduced IR and IMTc values, and minimal adverse reactions. |
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