| 曾志明,秦 琪,邢皓宇,胡真瑜,赵 盾.白杨素对高血压大鼠的降压作用及机制研究[J].现代生物医学进展英文版,2023,(21):4020-4025. |
| 白杨素对高血压大鼠的降压作用及机制研究 |
| Antihypertensive Effect and Mechanism of Chrysin on Hypertensive Rats |
| Received:April 01, 2023 Revised:April 26, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.21.004 |
| 中文关键词: 白杨素 高血压 大鼠 降压作用 机制 |
| 英文关键词: Chrysin Hypertension Rat Antihypertensive effect Mechanism |
| 基金项目:广东省自然科学基金项目（2017A030313745） |
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| 中文摘要: |
| 摘要 目的：探讨白杨素对高血压大鼠的降压作用及作用机制。方法：8只WKY大鼠为对照组，40只SHR大鼠随机分为模型组、卡托普利组和白杨素高、中、低剂量组，分别给予相应剂量药物治疗，每日1次，干预4周。实验期间观察各组大鼠收缩压（SBP）和舒张压（DBP）改善情况，酶联免疫吸附法（ELISA ）检测大鼠动脉血清中一氧化氮合酶（eNOS）、一氧化氮（NO）、内皮素（ET-1）和血管紧张素Ⅱ（AngⅡ）水平，马松染色（Masson）和苏木精-伊红染色法 ( HE) 观察大鼠心肌组织病理变化。结果：治疗后，与模型组相比，对照组、卡托普利组和白杨素高、中、低剂量组SBP和DBP均明显下降，血清eNOS和NO显著上升，ET-1和AngⅡ明显下降，差异具有统计学意义（P＜0.05），其中白杨素高剂量组改善情况优于白杨素低、中剂量组（P＜0.05）；心肌细胞相关病理损伤减轻，白杨素高剂量组改善情况优于白杨素中、低剂量组。结论：白杨素可能通过调节血管舒缩因子和肾素-血管紧张素-醛固酮系统降低血压，并改善心肌组织病理损伤。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the antihypertensive effect and mechanism of chrysin on hypertensive rats. Methods: 8 WKY rats as the control group, 40 SHR rats were randomly divided into model group, captopril group and chrysin high, medium and low dose group, respectively give corresponding dose of medication, once per day, intervention in 4 weeks. The improvement of systolic blood pressure(SBP)and diastolic blood pressure(DBP) in each group was observed during the experiment. Method of enzyme linked immunosorbent assay(ELISA) were used to detect serum nitric oxide synthase(eNOS), nitric oxide(NO), endothelin(ET-1) and angiotensin Ⅱ(AngⅡ) levels in artery of rats. Masson and Hematoxylin-eosin staining(HE) was used to observe the pathological changes of myocardial tissue in rats. Results: After treatment, compared with model group, control group, captopril group and chrysin high, medium and low dose group both SBP and DBP decreased obviously, and eNOS and NO significant rise, ET-1 and Ang Ⅱ declined obviously, difference is statistically significant(P＜0.05), and the improvement of the high-dose group was better than that of the low-dose and medium-dose group(P＜0.05). The pathological damage related to cardiac cells was alleviated, and the improvement in the high dose group was better than that in the medium and low dose groups. Conclusion: Chrysin may reduce blood pressure by regulating vasomotor factor and renin-angiotensin-aldosterone system and improve myocardial pathological injury. |
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