| 李 旻,徐陆周,李雅芹,吕品菊,王 若,彭 程,孔凌蔚.自适应性生物反馈训练对出口梗阻型便秘患者肛肠动力学、胃肠激素水平及负性情绪的影响[J].现代生物医学进展英文版,2023,(20):3964-3968. |
| 自适应性生物反馈训练对出口梗阻型便秘患者肛肠动力学、胃肠激素水平及负性情绪的影响 |
| Effects of Adaptive Biofeedback Training on Anorectal Dynamics, Gastrointestinal Hormone Levels and Negative Emotions in Patients with Outlet Obstruction Constipation |
| Received:March 10, 2023 Revised:March 31, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.20.033 |
| 中文关键词: 自适应性生物反馈训练 出口梗阻型便秘 肛肠动力学 胃肠激素 负性情绪 |
| 英文关键词: Adaptive biofeedback training Outlet obstruction constipation Anorectal dynamics Gastrointestinal hormone Negative emotion |
| 基金项目:江苏省卫生健康委医学创新中心项目[苏卫科教（2022）15号]；江苏省科技成果转化专项资金项目（BA2020005） |
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| 中文摘要: |
| 摘要 目的：探讨自适应性生物反馈训练（ABF）对出口梗阻型便秘（OOC）患者肛肠动力学、胃肠激素水平及负性情绪的影响。方法：选取2021年6月～2022年12月江苏省中医院收治的104例OOC患者作为研究对象，按照随机数字表法分为观察组、对照组各52例。对照组采用固定式生物反馈训练（FBF）治疗，观察组采用ABF治疗。比较两组临床疗效、治疗前后便秘症状评分、肛肠动力学指标（直肠肛门压力梯度、直肠初始感觉阈值及直肠排便感觉阈值）、胃肠激素[P物质（SP）、胃动素（MTL）、胃泌素（GAS）]水平及负性情绪[汉密尔顿焦虑量表（HAMA）与汉密尔顿抑郁量表（HAMD）]。结果：治疗后两组各项便秘症状评分和总评分均低于治疗前，且观察组低于对照组（P＜0.05）。观察组总有效率96.15%高于对照组82.69%（P＜0.05）。治疗后两组直肠肛门压力梯度高于治疗前，且观察组高于对照组；两组直肠初始感觉阈值及直肠排便感觉阈值低于治疗前，且观察组低于对照组（P＜0.05）。治疗后两组血清SP、MTL、GAS水平高于治疗前，且观察组高于对照组（P＜0.05）。治疗后两组HAMA、HAMD评分低于治疗前，且观察组低于对照组（P＜0.05）。结论：ABF可有效改善OOC患者临床症状、肛肠动力学、胃肠激素水平及负性情绪，提高临床疗效，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of adaptive biofeedback training (ABF) on anorectal dynamics, gastrointestinal hormone levels and negative emotions in patients with outlet obstructive constipation (OOC). Methods: 104 OOC patients admitted to Jiangsu Province Hospital of Traditional Chinese Medicine from June 2021 to December 2022 were selected as research objects, and were divided into observation group and control group with 52 cases in each group according to random number table method.The control group was treated with fixed biofeedback training (FBF), and the observation group was treated with ABF. The clinical efficacy, constipation symptom score, anorectal kinetic indexes (rectal anal pressure gradient, rectal initial sensory threshold, rectal defecation sensory threshold), gastrointestinal hormones [Substance P (SP), motilin (MTL), gastrin(GAS)] levels and negative emotions[Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD)] before and after treatment were compared between the two groups. Results: After treatment, the scores of constipation symptoms and total scores of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). The total effective rate of observation group was 96.15% higher than that 82.69% of control group(P<0.05). After treatment, the rectal anal pressure gradient in two groups was higher than before treatment, and the observation group was higher than the control group; the rectal initial sensory threshold and rectal defecation sensory threshold in two groups was lower than before treatment, and the observation group was lower than the control group (P<0.05). After treatment,the serum SP, MTL and GAS levels of the two groups were higher than before treatment, and the observation group was higher than the control group (P<0.05). After treatment, the HAMA and HAMD scores of the two groups were lower than before treatment, and the observation group was lower than the control group (P<0.05). Conclusion: ABF can effectively improve the clinical symptoms, anal motility, gastrointestinal hormone levels, and negative emotions of OOC patients, improve clinical efficacy, and is worthy of clinical promotion and application. |
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