| 王依雯,桂 茜,张小文,李秀兰,唐纯志.针刺周期疗法对气滞血瘀型原发性痛经患者性激素、疼痛因子和炎症因子的影响[J].现代生物医学进展英文版,2023,(20):3860-3864. |
| 针刺周期疗法对气滞血瘀型原发性痛经患者性激素、疼痛因子和炎症因子的影响 |
| The Effect of Acupuncture Cycle Therapy on Sexual Hormones, Pain Factors, and Inflammatory Factors in Patients with Primary Dysmenorrhea of Qi Stagnation and Blood Stasis Type |
| Received:April 06, 2023 Revised:April 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.20.012 |
| 中文关键词: 针刺周期疗法 气滞血瘀型 原发性痛经 性激素 疼痛因子 炎症因子 |
| 英文关键词: Acupuncture cycle therapy Qi stagnation and blood stasis type Primary dysmenorrhea Sexual hormones Pain factors Inflammatory factors |
| 基金项目:国家自然科学基金项目（81173350）；广东省中医药局科研项目（20162147） |
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| 中文摘要: |
| 摘要 目的：探讨针刺周期疗法对气滞血瘀型原发性痛经（PD）患者性激素、疼痛因子和炎症因子的影响。方法：选取东莞市中医院2021年1月~2022年1月期间收治的PD患者122例作为研究对象，根据信封抽签法分为对照组（布洛芬缓释胶囊治疗）和研究组（对照组的基础上接受针刺周期疗法），各为61例。对比两组疗效、中医证候积分、中文版COX痛经症状量表评分、疼痛视觉模拟（VAS）评分、炎症因子[白细胞介素（IL）-1β、IL-6、肿瘤坏死因子-α（TNF-α）]、疼痛因子[前列腺素E2（PGE2）、前列腺素F2α（PGF2α）、P物质（SP）]和性激素[雌二醇（E2）、孕酮（P）]。结果：研究组的临床总有效率为93.44%（57/61），高于对照组的75.41%（46/61）（P<0.05）。治疗3个疗程后研究组中医证候总分、中文版COX痛经症状量表评分、VAS评分均低于对照组同期（P<0.05）。治疗3个疗程后后IL-1β、IL-6、TNF-α均下降，且研究组均低于对照组同期（P<0.05）。治疗3个疗程后研究组SP、PGF2α均低于对照组同期，PGE2均高于对照组同期（P<0.05）。治疗3个疗程后研究组E2低于对照组同期，P高于对照组同期（P<0.05）。结论：针刺周期疗法可有效改善气滞血瘀型PD患者性激素、疼痛因子和炎症因子水平，治疗效果明显。 |
| 英文摘要: |
| ABSTRACT Objective: Explore the effects of acupuncture cycle therapy on sexual hormones, pain factors, and inflammatory factors in patients with primary dysmenorrhea (PD) of qi stagnation and blood stasis type. Methods: 122 patients with PD who were admitted to Dongguan Traditional Chinese Medicine Hospital from January 2021 to January 2022 were selected as research objects, and they were divided into control group (treated with ibuprofen sustained release capsules) and study group (On the basis of the control group, receive acupuncture cycle therapy) according to envelope lottery method, 61 cases in each group. The therapeutic effects, traditional Chinese medicine syndrome scores, Chinese version COX dysmenorrhea symptom scale scores, pain visual analogue (VAS) scores, inflammatory factors [interleukin-1 (IL-1)-β、 IL-6, Tumor Necrosis Factor-α(TNF-α)], Pain factors [prostaglandin E2 (PGE2), prostaglandin F2α（PGF2α）, Substance P (SP) and sex hormones [estradiol (E2), progesterone (P)] were compaerd between two groups. Results: The total clinical effective rate of the study group was 93.44% (57/61), which was higher than 75.41% (46/61) of the control group (P<0.05). After three courses of treatment, the total score of traditional Chinese medicine syndromes, Chinese version COX dysmenorrhea symptom scale score, and VAS score of the study group were lower than those of the control group during the same period (P<0.05). After three courses of treatment, IL-1β, IL-6, TNF-α all decreased, and the study group was lower than the control group during the same period (P<0.05).After three courses of treatment, the study group SP, PGF2α both were lower than the control group during the same period, and PGE2 was higher than the control group during the same period (P<0.05). After three courses of treatment, E2 in the study group was lower than that in the control group during the same period, while P was higher than that in the control group during the same period (P<0.05). Conclusion: Acupuncture cycle therapy can effectively improve the levels of sex hormones, pain factors, and inflammatory factors in patients with PD of Qi stagnation and blood stasis type PD, and the effect of the treatment is significant. |
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