| 李 华,董丹丹,吴 昊,姜玉连,刘佩林,张国勇.血清NT-proBNP、sAXL联合MT对左室射血分数保留的心力衰竭患者预后不良的预测价值[J].现代生物医学进展英文版,2023,(20):3831-3835. |
| 血清NT-proBNP、sAXL联合MT对左室射血分数保留的心力衰竭患者预后不良的预测价值 |
| Predictive Value of Serum NT-proBNP, sAXL Combined with MT for Poor Prognosis in Heart Failure with Preserved Ejection Fraction Patients of Left Ventricular |
| Received:April 23, 2023 Revised:May 18, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.20.006 |
| 中文关键词: 左室射血分数保留的心力衰竭 N末端前体B型利钠肽 可溶性AXL 褪黑素 预后 预测价值 |
| 英文关键词: Heart failure with preserved ejection fraction of left ventricular N-terminal pro B type natriuretic peptide Soluble AXL Melatonin Prognosis Predictive value |
| 基金项目:中国医学科学院临床与转化医学研究基金项目（2020-I2M-C&T-B-065） |
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| 中文摘要: |
| 摘要 目的：探讨血清N末端前体B型利钠肽（NT-proBNP）、可溶性AXL（sAXL）联合褪黑素（MT）对左室射血分数保留的心力衰竭（HFpEF）患者预后不良的预测价值。方法：选取2018年1月～2020年12月首都医科大学附属北京同仁医院心血管中心收治的100例HFpEF患者为HFpEF组，根据预后情况分为预后不良组和预后良好组，另选取同期54名体检健康志愿者为对照组。采用酶联免疫吸附法检测血清NT-proBNP、sAXL、MT水平。采用多因素Logistic回归分析HFpEF患者预后不良的因素，采用受试者工作特征（ROC）曲线分析血清NT-proBNP、sAXL、MT水平对HFpEF患者预后不良的预测价值。结果：HFpEF组血清NT-proBNP、sAXL水平高于对照组，MT水平低于对照组（P＜0.05）。随访6个月，100例HFpEF患者预后不良发生率为31.00%（31/100）。多因素Logistic回归分析显示，纽约心脏学会（NYHA）心功能分级≥Ⅲ级、NT-proBNP、sAXL升高为HFpEF患者预后不良的独立危险因素，MT升高为独立保护因素（P＜0.05）。ROC曲线分析显示，血清NT-proBNP、sAXL联合MT预测HFpEF患者预后不良的曲线下面积大于NT-proBNP、sAXL、MT单独预测。结论：血清NT-proBNP、sAXL水平升高和MT降低与HFpEF患者预后不良有关，可能成为预测HFpEF患者预后不良的辅助指标，血清NT-proBNP、sAXL联合MT预测HFpEF患者预后不良的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of serum N-terminal pro B type natriuretic peptide (NT-proBNP) and soluble AXL (sAXL) combined with melatonin (MT) for poor prognosis in heart failure with preserved ejection fraction (HFpEF) patients of left ventricular. Methods: 100 cases of HFpEF patients who were admitted to Cardiovascular center of Beijing Tongren Hospital Affiliated to Capital Medical University from January 2018 to December 2020 were selected as HFpEF group, and they were divided into poor prognosis group and good prognosis group according to the prognosis, and 54 healthy volunteers during the same period were selected as control group. Serum NT-proBNP, sAXL and MT levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the factors of poor prognosis in HFpEF patients, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum NT-proBNP, sAXL and MT levels for poor prognosis in HFpEF patients. Results: The serum NT-proBNP and sAXL levels in the HFpEF group were higher than those in the control group, while MT level was lower than that in the control group (P＜0.05). After 6 months of follow-up, the incidence rate of poor prognosis was 31.00% (31/100) in 100 case of HFpEF patients. Multivariate Logistic regression analysis showed that the New York Heart Society (NYHA) cardiac function grade ≥Ⅲ grade, the elevated NT-proBNP and sAXL were independent risk factors for poor prognosis in HFpEF patients, and the elevated MT was independent protective factor (P＜0.05). ROC curve analysis showed that the area under curve of serum NT-proBNP and sAXL combined with MT in predicting poor prognosis of HFpEF patients was greater than that of NT-proBNP, sAXL and MT alone. Conclusion: Elevated serum NT-proBNP and sAXL levels and decreased MT are associated with poor prognosis in HFpEF patients, may serve as auxiliary indicators to predict poor outcomes in HFpEF patients, serum NT-proBNP and sAXL combined with MT is of high value in predicting poor prognosis in HFpEF patients. |
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