王露露,王高峰,刘晓林,张琰琰,陈永玲.冠心病患者动态心电图参数与血清YKL-40、LTBP-2水平的关系研究[J].现代生物医学进展英文版,2023,(19):3783-3787. |
冠心病患者动态心电图参数与血清YKL-40、LTBP-2水平的关系研究 |
Relationship between Dynamic Electrocardiogram Parameters and Serum YKL-40, LTBP-2 in Patients with Coronary Heart Disease |
Received:April 30, 2023 Revised:May 23, 2023 |
DOI:10.13241/j.cnki.pmb.2023.19.037 |
中文关键词: 冠心病 动态心电图 甲壳质酶蛋白40 潜在转化生长因子结合蛋白2 |
英文关键词: Coronary heart disease Dynamic electrocardiogram Chitinase-3-like-1 protein Latent transforming growth factor binding protein 2 |
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中文摘要: |
摘要 目的:探讨冠心病患者动态心电图参数与血清甲壳质酶蛋白40(YKL-40)、潜在转化生长因子结合蛋白2(LTBP-2)水平的关系。方法:选取本院2020年3月至2023年4月154例冠心病患者纳入冠心病组(其中单支病变38例,双支病变57例,多支病变59例;Gensini积分评估冠状动脉狭窄程度包括轻度42例,中度60例,重度52例),另选择于本院进行健康体检者90例纳入对照组,所有纳入对象均接受动态心电图检查,并检测血清YKL-40、LTBP-2水平,分析冠心病患者动态心电图参数与血清指标的关系。结果:冠心病组24 h内全部正常心动周期的标准差(SDNN)、每5 min正常R-R间期标准差(SDANN)、相邻正常心动周期差值均方根(RMSSD)、相邻2个正常心动周期差值>50 ms个数百分比(PNN50)水平低于对照组,低频与高频功率之比(LF/HF)水平高于对照组(P<0.05);不同冠脉病变狭窄范围患者SDNN、SDANN、RMSSD、PNN50水平比较,多支病变<双支病变<单支病变,LF/HF水平比较,多支病变>双支病变>单支病变(P<0.05);不同冠脉病变狭窄程度患者SDNN、SDANN、RMSSD、PNN50水平比较,重度<中度<轻度,LF/HF水平比较,重度>中度>轻度(P<0.05);冠心病组血清YKL-40、LTBP-2水平高于对照组,且多支病变>双支病变>单支病变(P<0.05);不同冠脉病变狭窄程度患者血清YKL-40、LTBP-2水平比较,重度>中度>轻度(P<0.05);冠心病患者动态心电图参数SDNN、SDANN、RMSSD、PNN50水平与血清YKL-40、LTBP-2水平呈现负相关,LF/HF水平与血清YKL-40、LTBP-2水平呈现正相关(P<0.05)。结论:冠心病患者血清YKL-40、LTBP-2呈高表达,且其表达水平随冠脉病变狭窄范围和严重程度增加而升高,与动态心电图指标SDNN、SDANN、RMSSD、PNN50水平呈现负相关,与LF/HF水平呈现正相关。 |
英文摘要: |
ABSTRACT Objective: To explore the relationship between dynamic electrocardiogram parameters and levels of serum chitinase-3-like-1 protein (YKL-40) and latent transforming growth factor binding protein 2 (LTBP-2) in patients with coronary heart disease (CHD). Methods: A total of 154 patients with CHD in the hospital were enrolled as CHD group between March 2020 and April 2022, including 38 cases with single-vessel disease, 57 cases with double-vessel disease and 59 cases with multiple-vessel disease. The severity of coronary stenosis was evaluated by Gensini scores (42 mild cases, 60 moderate cases, 52 severe cases). A total of 90 healthy controls were enrolled as control group. All included objects underwent dynamic electrocardiogram examination. The levels of serum YKL-40 and LTBP-2 were detected, and their relationship with dynamic electrocardiogram parameters was analyzed. Results: The standard deviation of NN intervals (SDNN), standard deviation of average NN intervals (SDANN), square root of the mean of the squared differences between adjacent normal RR intervals/root mean square differences of successive R-R (RMSSD) and percent of NN50 in the total number of normal-to-normal intervals (PNN50) in CHD group were lower than those in control group, while ratio of low frequency to high frequency (LF/HF) was higher than that in control group (P<0.05). In patients with different ranges of coronary stenosis, SDNN, SDANN, RMSSD and PNN50 were the highest in those with single-vessel disease, followed by double-vessel disease and multiple-vessel disease, while LF/HF was on the contrary (P<0.05). In patients with different severity of coronary stenosis, SDNN, SDANN, RMSSD and PNN50 were the highest in those with mild stenosis, followed by moderate stenosis and severe stenosis, while LF/HF was on the contrary (P<0.05). The levels of serum YKL-40 and LTBP-2 in CHD group were higher than those in control group, and which were the highest in patients with multiple-vessel disease, followed by double-vessel disease and single-vessel disease (P<0.05). The levels of serum YKL-40 and LTBP-2 were the highest in patients with severe coronary stenosis, followed by moderate stenosis and mild stenosis (P<0.05). SDNN, SDANN, RMSSD and PNN50 were negatively correlated with levels of serum YKL-40 and LTBP-2, while LF/HF was positively correlated with them (P<0.05). Conclusion: The expression levels of serum YKL-40 and LTBP-2 are up-regulated in patients with CHD. With the increase of coronary stenosis range and severity, levels of serum YKL-40 and LTBP-2 were increased, and which are negatively correlated with SDNN, SDANN, RMSSD and PNN50, while positively correlated with LF/HF. |
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