| 凌 格,姚茂篪,叶玉昌,黄炜璐,杨芙蓉.心可舒片联合盐酸地尔硫卓片治疗老年冠心病心绞痛的临床研究[J].现代生物医学进展英文版,2023,(19):3749-3753. |
| 心可舒片联合盐酸地尔硫卓片治疗老年冠心病心绞痛的临床研究 |
| Clinical Study of Xinkeshu Tablets Combined with Diltiazem Hydrochloride Tablets in the Treatment of Angina Pectoris in Elderly Patients with Coronary Heart Disease |
| Received:March 04, 2023 Revised:March 27, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.19.030 |
| 中文关键词: 心可舒片 盐酸地尔硫卓片 老年 冠心病心绞痛 疗效 |
| 英文关键词: Xinkeshu tablets Diltiazem hydrochloride tablets Elderly Coronary heart disease and angina pectoris Curative effect |
| 基金项目:湖北省卫生健康委员会基金资助项目（WJ2019B0405） |
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| 中文摘要: |
| 摘要 目的：探讨心可舒片联合盐酸地尔硫卓片治疗老年冠心病心绞痛的临床疗效。方法：按照随机数字表法将湖北民族大学附属民大医院和武汉市江夏区第一人民医院2019年4月-2021年9月间收治的98例老年冠心病心绞痛患者分为对照组（盐酸地尔硫卓片治疗，n=49）和观察组（心可舒片联合盐酸地尔硫卓片治疗，n=49）。观察两组疗效、心绞痛缓解情况、血脂指标、血管内皮功能指标、心功能指标、血液流变学指标和不良反应发生情况。结果：观察组的临床总有效率高于对照组（P<0.05）。治疗4周后，与对照组相比，观察组的心绞痛发作频率减少，全血黏度、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、内皮素-1（ET-1）、血浆比黏度、左室收缩末期内径（LVESD）、红细胞压积更低，一氧化氮（NO）、高密度脂蛋白胆固醇（HDL-C）、左心室射血分数（LVEF）、心排血量（CO）更高，心绞痛发作持续时间缩短（P<0.05）。两组不良反应发生率对比无差异（P>0.05）。结论：心可舒片联合盐酸地尔硫卓片治疗老年冠心病心绞痛，可缓解心绞痛症状，改善血液流变学、心功能、血脂和血管内皮功能。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of Xinkeshu Tablets combined with Diltiazem Hydrochloride Tablets in the treatment of angina pectoris in elderly patients with coronary heart disease. Methods: 98 elderly patients with angina pectoris of coronary heart disease admitted to The People's University Hospital affiliated to Hubei University for Nationalities and Wuhan Jiangxia District First People's Hospital from April 2019 to September 2021 were divided into control group (49 cases treated with diltiazem hydrochloride tablets, n=49) and observation group (treated with Xinkeshu tablets and diltiazem hydrochloride tablets, n=49) according to the method of random number table. The curative effect, angina relief, blood lipid index, vascular endothelial function index, cardiac function index, hemorheology index and adverse reactions of the two groups were observed. Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05).4 weeks after treatment, compared with the control group, the frequency of angina pectoris in the observation group was reduced, and whole blood viscosity, triglyceride (TG),total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), endothelin-1 (ET-1), plasma specific viscosity, left ventricular end-systolic diameter (LVESD), hematocrit, nitric oxide (NO), high density lipoprotein cholesterol (HDL-C),left ventricular ejection fraction (LVEF) , cardiac output (CO) was higher, the duration of angina pectoris was shorter(P<0.05). There was no difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Xinkeshu tablets combined with diltiazem hydrochloride tablets can relieve the symptoms of angina pectoris and improve hemorheology, cardiac function, blood lipids and vascular endothelial function in elderly patients with coronary heart disease and angina pectoris. |
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