| 徐丽峰,梁莉萍,刘林林,李 辉,李聪慧,井山泉.mGS评分联合血清 FGFR-1、PTX3对脑室出血患者脑室外引流术后预后不良的预测价值[J].现代生物医学进展英文版,2023,(19):3704-3708. |
| mGS评分联合血清 FGFR-1、PTX3对脑室出血患者脑室外引流术后预后不良的预测价值 |
| Prognostic Value of mGS Score Combined with Serum FGFR-1 and PTX3 for Poor Prognosis in Patients with Intraventricular Hemorrhage after External Ventricular Drainage |
| Received:March 05, 2023 Revised:March 27, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.19.021 |
| 中文关键词: 脑室出血 脑室外引流 mGS评分 FGFR-1 PTX3 预后 预测价值 |
| 英文关键词: Intraventricular hemorrhage External ventricular drainage mGS score FGFR-1 PTX3 Prognosis Prognostic Value |
| 基金项目:河北省医学科学研究重点课题计划项目（20160702） |
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| 中文摘要: |
| 摘要 目的：探讨脑室改良的Graeb评分（mGS评分）联合血清成纤维细胞生长因子受体-1（FGFR-1）、正五聚蛋白3（PTX3）对脑室出血（IVH）患者脑室外引流术后预后不良的预测价值。方法：选择河北医科大学第一医院2020年2月至2022年2月行脑室外引流治疗的109例IVH患者，出院后3个月采用格拉斯哥预后评分（GOS）评价患者预后，根据GOS评分将IVH患者分为预后不良组（51例）和预后良好组（58例）。术前评估mGS评分，并检测血清FGFR-1、PTX3水平。多因素Logistic回归分析法分析影响IVH患者脑室外引流术后预后不良的因素。绘制受试者工作特征曲线（ROC）分析mGS评分联合血清 FGFR-1、PTX3预测IVH患者脑室外引流术后预后不良的价值。结果：预后不良组术前mGS评分、血清PTX3水平高于预后良好组（P＜0.05），血清FGFR-1水平低于预后良好组（P＜0.05）。并发脑疝、高mGS评分、高PTX3是IVH患者脑室外引流术后预后不良的危险因素（P＜0.05），高FGFR-1是保护因素（P＜0.05）。联合mGS评分和血清 FGFR-1、PTX3预测IVH患者脑室外引流术后预后不良的曲线下面积为0.894，高于以上各指标单独预测。结论：IVH脑室外引流术后预后不良患者mGS评分和血清PTX3水平增高，血清FGFR-1水平降低，联合mGS评分、血清FGFR-1和PTX3对IVH患者脑室外引流术后预后的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the predictive value of ventricular modified Graeb score (mGS score) combined with serum fibroblast growth factor receptor-1 (FGFR-1) and pentraxin 3 (PTX3) for poor prognosis in patients with intraventricular hemorrhage (IVH) after external ventricular drainage. Methods: 109 patients with IVH who received external ventricular drainage treatment from the First Hospital of Hebei Medical University from February 2020 to February 2022 were selected. Glasgow Outcome Scale score (GOS) was used to evaluate the prognosis of patients at 3 months after discharge. According to GOS score, the patients with IVH were divided into poor prognosis group (51 cases) and good prognosis group (58 cases). The mGS scores were evaluated, and serum FGFR-1 and PTX3 levels were detected before surgery. Multivariate Logistic regression analysis was used to analyze the factors affecting the poor prognosis of patients with IVH after external ventricular drainage. Receiver operating characteristic curve (ROC) was drawn to analyze the value of mGS score combined with serum FGFR-1 and PTX3 in predicting poor prognosis in patients with IVH after external ventricular drainage. Results: The preoperative mGS score and serum PTX3 level in the poor prognosis group were higher than those in the good prognosis group (P＜0.05), and serum FGFR-1 level was lower than that in the good prognosis group (P＜0.05). Complicated with cerebral hernia, high mGS score and high PTX3 were risk factors for poor prognosis in patients with IVH after external ventricular drainage (P＜0.05), and high FGFR-1 was protective factor (P＜0.05). The area under curve of combined mGS score and serum FGFR-1 and PTX3 predicting poor prognosis in patients with IVH after external ventricular drainage was 0.894, which was higher than that predicted by above indicators alone. Conclusion: The mGS score and serum PTX3 level increased, and serum FGFR-1 level decreased in patients of poor prognosis with IVH after external ventricular drainage. Combined mGS score, serum FGFR-1 and PTX3 has high prognostic value in patients with IVH after external ventricular drainage. |
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