| 魏天懿,卞恒杰,周 宇,张 坡,孔晓海.盐杜仲颗粒联合腰椎牵引治疗腰椎间盘突出症（气滞血瘀型）的效果及对患者疼痛、微炎症和氧化因子的影响[J].现代生物医学进展英文版,2023,(19):3673-3677. |
| 盐杜仲颗粒联合腰椎牵引治疗腰椎间盘突出症（气滞血瘀型）的效果及对患者疼痛、微炎症和氧化因子的影响 |
| Effects of Yanduzhong Granule Combined with Lumbar Traction on Treatment of Lumbar Intervertebral Disc Herniation (Qi Stagnation and Blood Stasis Type) and Its Influence on Pain, Microinflammation, and Oxidative Factors in Patientsa |
| Received:April 06, 2023 Revised:April 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.19.015 |
| 中文关键词: 盐杜仲颗粒 腰椎间盘突出症 气滞血瘀型 腰椎牵引 疼痛 微炎症 氧化 |
| 英文关键词: Yanduzhong granules Lumbar disc herniation Qi stagnation and blood stasis type Lumbar traction Pain Microinflammation Oxidation |
| 基金项目:江苏省科技计划面上项目（JD0106） |
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| 中文摘要: |
| 摘要 目的：探究盐杜仲颗粒联合腰椎牵引治疗腰椎间盘突出症（气滞血瘀型）的临床效果及对患者疼痛指标、血清微炎症和氧化因子的影响。方法：选择2019年6月至2022年6月我院骨一科收治的70例气滞血瘀型腰椎间盘突出症患者，分为对照组和研究组，各35例。对照组患者行腰椎牵引治疗，研究组在对照组基础上加服盐杜仲颗粒连续治疗1个月。比较两组患者临床疗效以及治疗前后视觉模拟评分（VAS）、日本骨科协会（JOA）腰椎功能评分、健康调查简表（SF-36）评分、中医症候积分和血清白细胞介素-1β（IL-1β）超氧化物歧化酶（SOD）水平和活性。结果：（1）研究组治疗总有效率为94.29%，显著高于对照组的60.00%（P<0.05）。（2）研究组患者治疗后3个月中医症候积分显著低于对照组（P<0.05）。（3）研究组的治疗3个月后的VAS评分显著低于对照组，JOA评分和SF-36评分较对照组高（P<0.05）。（4）研究组的治疗3个月后血清IL-1β低于对照组，血清SOD高于对照组（P<0.05）。结论：盐杜仲颗粒联合腰椎牵引能够显著改善腰椎间盘突出症（气滞血瘀型）患者的生活质量，提高临床疗效，减轻疼痛、炎性反应和氧化应激。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical effect of Yanduzhong Granule combined with lumbar traction in the treatment of lumbar disc herniation (Qi stagnation and blood stasis type) and its impact on pain indicators, serum microinflammation, and oxidation factors in patients. Methods: A total of 70 patients with lumbar intervertebral disc herniation of Qi stagnation and blood stasis type admitted to the Department of Orthopedics of our hospital from June 2019 to June 2022 were selected as research subjects. They were divided into a control group and a study group, with 35 patients in each group. The patients in the control group were treated with lumbar traction, while the study group was treated with Yanduzhong granules for 1 month on the basis of the control group. The clinical efficacy, visual analogue score (VAS), Japanese Orthopedic Association (JOA) lumbar function score, health survey summary table (SF-36) score, TCM syndrome score, and serum interleukin-1β (IL-1β), superoxide dismutase (SOD), levels and activities were compared between the two groups before and after treatment. Results: (1) The total effective rate of treatment in the study group was 94.29%, higher than 60.00% in the control group(P<0.05). (2) After 3 months of treatment, the TCM syndrome scores of patients in the study group were lower than those in the control group (P<0.05). (3) After 3 months of treatment, the VAS score in the study group was lower than that in the control group, while the JOA score and SF-36 score were significantly higher than those in the control group(P<0.05). (4) Serum IL-1β was lower than the control group and serum SOD was higher than the control group after 3 months of treatment in the study group (P<0.05). Conclusion: Yanduzhong granules combined with lumbar traction can significantly improve the quality of life of patients with lumbar disc herniation (Qi stagnation and blood stasis type), improve clinical efficacy, and reduce pain, inflammatory reactions, and oxidative stress.". |
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