| 桑 晔,张 蓓,刘春燕,佘 琴,孙 靖,张 敏.血清5-HT、TNF-α、补体C1q对重性抑郁障碍急性期患者抗抑郁疗效的影响[J].现代生物医学进展英文版,2023,(18):3528-3532. |
| 血清5-HT、TNF-α、补体C1q对重性抑郁障碍急性期患者抗抑郁疗效的影响 |
| Effects of Serum 5-HT, TNF-α and Complement C1q on Antidepressant Efficacy in Patients with Acute Stage of Major Depressive Disorder |
| Received:March 04, 2023 Revised:March 26, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.18.025 |
| 中文关键词: 5-羟色胺 肿瘤坏死因子-α 补体C1q 重性抑郁障碍 急性期 抗抑郁 疗效 |
| 英文关键词: 5-hydroxytryptamine Tumor necrosis factor-α Complement C1q Major depressive disorder Acute stage Antidepressant Efficacy |
| 基金项目:新疆维吾尔自治区卫生健康委青年医学科技人才专项基金（WJWY-201954） |
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| 中文摘要: |
| 摘要 目的：探讨血清5-羟色胺（5-HT）、肿瘤坏死因子-α（TNF-α）、补体C1q对重性抑郁障碍急性期患者抗抑郁疗效的影响。方法：选择2020年1月至2022年1月新疆精神卫生中心收治的185例首发重性抑郁障碍急性期患者，所有患者均接受抗抑郁药物治疗，根据疗效将患者分为无效组（32例）和有效组（153例）。治疗前、后检测血清5-HT、TNF-α、补体C1q水平，收集相关资料，多因素Logistic回归分析影响重性抑郁障碍急性期患者抗抑郁疗效的因素，受试者工作特征（ROC）曲线分析血清5-HT、TNF-α、补体C1q预测重性抑郁障碍急性期患者抗抑郁疗效的价值。结果：无效组治疗后血清5-HT、TNF-α、补体C1q与治疗前比较差异无统计学意义（P＞0.05），有效组治疗后血清5-HT较治疗前增高（P＜0.05），TNF-α、补体C1q较治疗前降低（P＜0.05）。无效组治疗后血清5-HT低于有效组，血清TNF-α、补体C1q高于有效组（P＜0.05）。多因素Logistic回归分析结果显示有自杀意念、高TNF-α、高补体C1q是重性抑郁障碍急性期患者抗抑郁治疗无效的危险因素，高5-HT是其保护因素（P＜0.05）。联合5-HT、TNF-α、补体C1q三项指标预测重性抑郁障碍急性期患者抗抑郁治疗无效的曲线下面积为0.828，高于单独指标预测的0.732、0.658、0.677。结论：重性抑郁障碍急性期抗抑郁治疗后无效患者血清5-HT偏低，TNF-α和补体C1q偏高，且与抗郁治疗无效有关，联合检测血清5-HT、TNF-α和补体C1q可预测抗抑郁疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of serum 5-hydroxytryptamine (5-HT), tumor necrosis factor-α (TNF-α) and complement C1q on antidepressant efficacy in patients with acute stage of major depressive disorder. Methods: 185 patients with acute stage of first-episode major depressive disorder who were admitted to Xinjiang Mental Health Center from January 2020 to January 2022 were selected. All patients received antidepressant therapy, and the patients were divided into non-effective group (32 cases) and effective group (153 cases) according to the efficacy. The levels of serum 5-HT, TNF-α and complement C1q were detected before and after treatment. Relevant data were collected, and the multivariate Logistic regression analysis was conducted to analyze the factors that affect the antidepressant efficacy in patients with acute stage of major depressive disorder. The value of serum 5-HT, TNF-α and complement C1q in predicting the antidepressant efficacy in patients with acute stage of major depressive disorder were analyzed by receiver operating characteristic (ROC) curve. Results: There were no significant differences in serum 5-HT, TNF-α and complement C1q between the non-effective group after treatment and before treatment (P＞0.05), while serum 5-HT in the effective group after treatment increased compared with before treatment (P＜0.05), and TNF-α and complement C1q decreased compared with before treatment (P＜0.05). After treatment, the serum 5-HT in the non-effective group was lower than that in the effective group, and the serum TNF-α and complement C1q were higher than those in the effective group (P＜0.05). Multivariate Logistic regression analysis showed that with suicidal ideation, high TNF-α and high complement C1q were risk factors for the failure of antidepressant treatment in patients with acute stage of major depressive disorder, and high 5-HT was protective factor (P＜0.05). The area under curve of the combination of 5-HT, TNF-α and complement C1q predicted the efficacy of antidepressant treatment in patients with acute stage of major depressive disorder was 0.828, which was higher than 0.732, 0.658 and 0.677 predicted by the single index. Conclusion: Serum 5-HT in patients with acute stage of major depressive disorder who have failure of antidepressant therapy is lower, and TNF-α and complement C1q are higher, which are related to the failure of anti-depression treatment. Combined detection of serum 5-HT, TNF-α and complement C1q could predict the antidepressant efficacy. |
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