| 艾合散·卡马力,肖开提·阿不都哈德尔,杨 鹏,钟 锴,姑丽吉米拉·阿地力,依力哈木·买买提.血清CEA、G-17、MK、ProGRP与胃癌根治术患者术后复发风险的关系研究[J].现代生物医学进展英文版,2023,(18):3494-3498. |
| 血清CEA、G-17、MK、ProGRP与胃癌根治术患者术后复发风险的关系研究 |
| Relationship Study between Serum Carcinoembryonic Antigen, Gastrin 17, Midkin, Progastrin Releasing Peptide and Postoperative Recurrence Risk in Patients with Radical Gastrectomy |
| Received:February 27, 2023 Revised:March 23, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.18.018 |
| 中文关键词: 胃癌 胃癌根治术 CEA G-17 MK ProGRP 复发 |
| 英文关键词: Gastric cancer Radical gastrectomy CEA G-17 MK ProGRP Recurrence |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2018D01C220） |
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| 中文摘要: |
| 摘要 目的：探讨血清癌胚抗原（CEA）、胃泌素17（G-17）、中期因子（MK）、胃泌素释放肽前体（ProGRP）与胃癌根治术（RG）患者术后复发风险的关系。方法：选取2018年1月～2020年8月新疆医科大学第一附属医院普外科收治的156例胃癌患者为胃癌组，根据RG后是否复发分为复发组和无复发组，另选取同期我院52名健康体检志愿者为对照组。收集胃癌患者临床资料，采用酶联免疫吸附法检测血清CEA、G-17、MK、ProGRP水平。通过单因素和多因素Logistic回归分析RG患者术后复发的影响因素，受试者工作特征（ROC）曲线分析血清CEA、G-17、MK、ProGRP水平对RG患者术后复发的预测价值。结果：与对照组比较，胃癌组血清CEA、G-17、MK、ProGRP水平升高（P＜0.05）。随访2年，失访2例，154例RG患者术后复发率为28.57%（44/154）。多因素Logistic回归分析显示，CEA、G-17、MK、ProGRP升高、TNM分期Ⅲ期、分化程度为低分化、淋巴结转移为RG患者术后复发的独立危险因素（P＜0.05）。ROC曲线分析显示，血清CEA、G-17、MK、ProGRP水平联合预测RG患者术后复发的曲线下面积（AUC）大于CEA、G-17、MK、ProGRP单独预测。结论：血清CEA、G-17、MK、ProGRP水平升高与RG患者术后复发密切相关，可能成为RG患者术后复发的辅助预测指标，且血清CEA、G-17、MK、ProGRP联合预测RG患者术后复发的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum carcinoembryonic antigen (CEA), gastrin 17 (G-17), midkine (MK) and progastrin releasing peptide (ProGRP) and postoperative recurrence risk in patients with radical gastrectomy (RG). Methods: 156 patients with gastric cancer who were admitted to the Department of General Surgery of the First Affiliated Hospital of Xinjiang Medical University from January 2018 to August 2020 were selected as the gastric cancer group, and they were divided into the recurrence group and the non-recurrence group according to whether the patients had recurrence after RG, and 52 healthy examination volunteers in our hospital during the same period were selected as the control group. Clinical data of patients with gastric cancer were collected, and serum CEA, G-17, MK and ProGRP levels were determined by enzymed-linked immunosorbent assay. Univariate and multivariate Logistic regression were used to analyze the influencing factors of postoperative recurrence in patients with RG. The predictive value of serum CEA, G-17, MK and ProGRP levels in patients with RG was analyzed by receiver operating characteristic (ROC) curve. Results: Compared with the control group, the serum CEA, G-17, MK and ProGRP levels in the gastric cancer group were increased (P＜0.05). After 2 years of follow-up, 2 cases were lost to follow-up, and the recurrence rate of 154 patients with RG was 28.57% (44/154). Multivariate Logistic regression analysis showed that elevated CEA, G-17, MK and ProGRP, TNM stage Ⅲ, low differentiation, lymph node metastasis were independent risk factors for postoperative recurrence in patients with RG (P＜0.05). ROC curve analysis showed that the area under curve (AUC) of the combined prediction of CEA, G-17, MK and ProGRP in patients with RG was greater than that of CEA, G-17, MK and ProGRP alone. Conclusion: The elevated levels of serum CEA, G-17, MK and ProGRP are closely related to postoperative recurrence in patients with RG, which may be an auxiliary predictor of postoperative recurrence in patients with RG, and the combined prediction of serum CEA, G-17, MK and ProGRP is of high value. |
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