| 徐海蓉,华 华,杨丽坤,王 蕊,李珊珊.梅花针叩刺联合桃红四物汤加味治疗气滞血瘀型白癜风的临床疗效及对血清免疫球蛋白和自身抗体的影响[J].现代生物医学进展英文版,2023,(18):3440-3444. |
| 梅花针叩刺联合桃红四物汤加味治疗气滞血瘀型白癜风的临床疗效及对血清免疫球蛋白和自身抗体的影响 |
| Clinical Efficacy of Plum Blossom Needle Tapping Combined with Jiawei Taohong Siwu Decoction in Treating Vitiligo of Qi Stagnation and Blood Stasis Type and its Influence on Serum Immunoglobulin and Autoantibody |
| Received:February 09, 2023 Revised:March 04, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.18.007 |
| 中文关键词: 梅花针叩刺 桃红四物汤加味 气滞血瘀型白癜风 临床疗效 免疫球蛋白 自身抗体 |
| 英文关键词: Plum blossom needle tapping Jiawei Taohong Siwu decoction Vitiligo of qi stagnation and blood stasis type Clinical efficacy Immunoglobulin Autoantibody |
| 基金项目:北京市中医药薪火传承"3+3"工程资助项目（2017-SZ-C-67） |
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| 中文摘要: |
| 摘要 目的：观察气滞血瘀型白癜风经桃红四物汤加味、梅花针叩刺联合治疗后的临床疗效及对血清免疫球蛋白（Ig）和自身抗体的影响。方法：根据随机数字表法将中国中医科学院广安门医院2019年3月~2022年4月期间收治的80例气滞血瘀型白癜风患者分为对照组（常规治疗的基础上结合梅花针叩刺治疗）和观察组（对照组的治疗基础上结合桃红四物汤加味治疗），各为40例。对比两组疗效、中医证候评分、白斑面积、出现黑素细胞时间、白斑的色素积分、血清自身抗体、Ig水平以及不良反应发生率。结果：观察组的临床总有效率为95.00%（38/40），高于对照组的75.00%（30/40）（P<0.05）。观察组治疗3个月后抗甲状腺球蛋白抗体（A-TG）、抗甲状腺过氧化物酶抗体（A-TPO）阳性率低于对照组（P<0.05）。观察组治疗3个月后面色晦暗、肌肤甲错、心烦不安、气郁不舒、失眠多梦评分低于对照组（P<0.05）。观察组治疗3个月后出现黑素细胞时间短于对照组，白斑的色素积分高于对照组，白斑面积小于对照组（P<0.05）。观察组治疗3个月后血清IgA、IgG、IgM高于对照组（P<0.05）。两组不良反应发生率比较无差异（P>0.05）。结论：气滞血瘀型白癜风经桃红四物汤加味联合梅花针叩刺治疗，临床症状得到显著改善，自身抗体阳性率降低，机体免疫力提高，且治疗安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the clinical effect of the combination of Jiawei Taohong Siwu decoction and plum blossom needle tapping in the treatment of vitiligo with qi stagnation and blood stasis and its influence on serum immunoglobulin (Ig) and autoantibodies. Methods: According to the method of random number table, 80 patients with vitiligo of qi stagnation and blood stasis type who were admitted in Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine from March 2019 to April 2022 were divided into the control group (combined with plum blossom needle tapping therapy on the basis of conventional therapy) and the observation group (combined with Jiawei Taohong Siwu decoction on the basis of treatment in the control group), each with 40 cases. The efficacy, traditional Chinese medical syndrome score, leukoplakia area, melanocyte appearance time, pigment score of leukoplakia, serum autoantibody, Ig level and adverse reaction rate in the two groups were compared. Results: The total clinical effective rate in the observation group was 95.00% (38/40), which was higher than 75.00% (30/40) in the control group (P<0.05). 3 months after treatment, the positive rates of anti thyroglobulin antibody (A-TG) and anti thyroid peroxidase antibody (A-TPO) in the observation group were lower than those in the control group (P<0.05). 3 months after treatment, the scores of dimmish and darkish complexion, onychomycosis cutis, upset, qi depression and discomfort, insomnia and dreaminess in the observation group was lower than those in the control group (P<0.05). 3 months after treatment, the melanocyte appearance time in the observation group was shorter than that in the control group, the pigment score of leukoplakia was higher than that in the control group, and the leukoplakia area was smaller than that in the control group (P<0.05). 3 months after treatment, the serum IgA, IgG and IgM in the observation group were higher than those in the control group (P<0.05). There was no difference in the incidence of adverse reactions in the two groups (P>0.05). Conclusion: Treatment of vitiligo with qi stagnation and blood stasis by Jiawei Taohong Siwu decoction combined with plum blossom needle tapping, the clinical symptoms are significantly improved, the positive rate of autoantibodies is reduced, the body immunity is improved, and the treatment is safe. |
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