| 胡忠顺,曹 彦,冯 俊,倪丹凤,杜自慧,冯文婷,李胜男.超声心动图结合血清miR-122对原发性高血压所致左心室功能改变的评估价值[J].现代生物医学进展英文版,2023,(17):3331-3335. |
| 超声心动图结合血清miR-122对原发性高血压所致左心室功能改变的评估价值 |
| Evaluation Value of Echocardiography Combined with Serum miR-122 on Left Ventricular Function Changes Induced by Essential Hypertension |
| Received:March 03, 2023 Revised:March 28, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.17.025 |
| 中文关键词: 原发性高血压 超声心动图 微RNA-122 心室功能 诊断价值 |
| 英文关键词: Essential hypertension Echocardiography MicroRNA-122 Ventricular function Diagnostic value |
| 基金项目:安徽省重点研究与开发计划项目（1704f0804045）；六安市科技基金计划项目（2022lakj025） |
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| 中文摘要: |
| 摘要 目的：探讨超声心动图结合血清微小RNA-122（miR-122）对原发性高血压（EH）所致左心室功能改变的评估价值。方法：选择2020年01月-2022年06月本院收治的58例EH患者作为研究组，另选择同期62例体检健康者作为对照组。所有研究对象均行超声心动图检查、血清miR-122检测，比较两组间超声心动图定量参数、血清miR-122水平差异，分析血清miR-122与左心室功能指标的相关性。通过绘制受试者工作特征曲线（ROC）并计算曲线下面积（AUC）分析超声心动图定量参数、血清miR-122单独诊断EH所致左心室功能改变的最佳诊断阈值以及相应敏感度、特异度；联合诊断采用多因素Logistic回归分析并绘制ROC曲线评估其诊断效能。结果：研究组患者左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、室间隔舒张末期厚度（IVSD）、左心室后壁舒张末期厚度（LVPWD）、E与室间隔和侧壁处二尖瓣环舒张早期运动速度e'室间隔和e'侧壁均值的比值（E/e'）、左心室舒张末期容积（EDV）和左心室收缩末期容积（ESV）、血清miR-122水平显著高于对照组（P<0.05），二尖瓣口舒张早期血流速度E与舒张晚期血流速度A比值（E/A）显著低于对照组（P<0.05），而两组间左心室射血分数（EF）差异不具有统计学意义（P＞0.05）。血清miR-122水平与LVEDD、LVESD、EDV、ESV呈正相关(P<0.05），与其他超声心动图定量参数IVSD、LVPWD、EF、E/A、E/e'无显著相关性（P＜0.05）。与单独诊断相比较，超声心动图定量参数结合血清miR-122诊断EH所致左心室功能改变的AUC、约登指数、敏感度、特异度最高。结论：超声心动图结合血清miR-122能够准确评估EH所致左心室功能改变情况，有助于指导临床治疗方案的选择。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the value of echocardiography combined with serum microRNA-122 (miR-122) in evaluating left ventricular function changes caused by essential hypertension (EH). Methods: 58 EH patients admitted to our hospital from January 2020 to June 2022 were selected as the study group, and 62 healthy persons in the same period were selected as the control group. All subjects were examined by echocardiography and serum miR-122. The differences of quantitative parameters of echocardiography and serum miR-122 levels between the two groups were compared, and the correlation between serum miR-122 and left ventricular function indexes was analyzed.The optimal diagnostic threshold of the quantitative parameters of echocardiography, serum miR-122 alone for to diagnose left ventricular function changes caused by EH, as well as the corresponding sensitivity and specificity were analyzed by drawing the receiver operating characteristic curve (ROC) and calculating the area under the curve (AUC). The joint diagnosis uses multivariate logistic regression analysis and draws ROC curves to evaluate its diagnostic efficacy. Results: In the study group, left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), interventricular septum end diastolic thickness (IVSD), left ventricular posterior wall end diastolic thickness (LVPWD), the ratio of E to the mean value of the early diastolic velocity of the mitral annulus at the interventricular septum and side wall, e 'interventricular septum and e' side wall (E/e '), left ventricular end diastolic volume (EDV) and left ventricular end systolic volume(ESV), serum miR-122 level was significantly higher than the control group (P<0.05), and the ratio of early diastolic blood flow velocity E to late diastolic blood flow velocity A (E/A) was significantly lower than the control group (P<0.05). However,there was no statistically significant difference in left ventricular ejection fraction (EF) between the two groups (P>0.05). The serum miR-122 level was positively correlated with LVEDD, LVESD, EDV, and ESV (P<0.05), but not significantly correlated with other quantitative parameters of echocardiography IVSD, LVPWD, EF, E/A, E/e'(P<0.05). Compared with individual diagnosis,the combination of quantitative parameters of echocardiography and serum miR-122 has the highest AUC, Jordan index, sensitivity, and specificity in diagnosing left ventricular function changes caused by EH(P<0.05). Conclusion: Echocardiography combined with serum miR-122 can accurately evaluate the changes of left ventricular function caused by EH, which is helpful to guide the selection of clinical treatment plan. |
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