| 潘思颖,朱 玲,汤淇云,韩倩倩,祝子惠.帕金森病患者营养不良的影响因素分析及与衰弱、认知功能和跌倒风险的关系研究[J].现代生物医学进展英文版,2023,(17):3278-3282. |
| 帕金森病患者营养不良的影响因素分析及与衰弱、认知功能和跌倒风险的关系研究 |
| Analysis of the Influencing Factors of Malnutrition in Patients with Parkinson's Disease and its Relationship Study with Frailty, Cognitive Function and Fall Risk |
| Received:March 13, 2023 Revised:March 31, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.17.015 |
| 中文关键词: 帕金森病 营养不良 影响因素 衰弱 认知功能 跌倒风险 |
| 英文关键词: Parkinson's disease Malnutrition Influencing factors Frailty Cognitive function Fall risk |
| 基金项目:江苏省老年医学科技发展基金专项项目（JGS2019ZXYY20） |
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| 中文摘要: |
| 摘要 目的：分析帕金森病（PD）患者营养不良的影响因素，并观察营养不良对衰弱、认知功能和跌倒风险的影响。方法：选取江苏省人民医院2019年3月至2022年3月期间收治的100例PD患者。采用简易营养评价量表（MNA）对研究对象进行营养状态评估，将100例患者分为营养不良组（n=52）和无营养不良组（n=48）。获取所有患者的一般资料，经Logistic回归分析PD患者营养不良的影响因素。同时对比无营养不良组、营养不良组的衰弱、认知功能和跌倒风险情况。结果：PD患者营养不良与年龄、体质量指数、Hoehn-Yahr分级、居住地、婚姻状况、血红蛋白、白蛋白、前白蛋白、每日左旋多巴等效剂量（LEDDs）、睡眠状况、焦虑状况、抑郁状况、味觉障碍、吞咽障碍、食欲下降有关（P<0.05）。Logistic回归分析，结果显示：年龄偏大、Hoehn-Yahr分级为III~V级、睡眠状况偏差、焦虑/抑郁状况严重、味觉障碍、吞咽障碍、食欲下降、LEDDs偏高是PD患者出现营养不良的危险因素（P<0.05）。营养不良组的衰弱发生率高于无营养不良组，衰弱前期、无衰弱发生率低于无营养不良组（P<0.05）。营养不良组的简易精神状态检查量表（MMSE）、蒙特利尔认知评估量表（MOCA）评分低于无营养不良组（P<0.05）。营养不良组的起立-行走计时测验（TUGT）时间、站起测验（CRT）时间长于无营养不良组，走直线步态测验（TGT）正确步数少于无营养不良组（P<0.05）。结论：PD患者营养不良发生风险较高，且受到年龄、睡眠状况、焦虑状况、抑郁状况、Hoehn-Yahr分级、味觉障碍、吞咽障碍、食欲下降、LEDDs的影响，且营养不良可加重衰弱、降低认知功能和增加跌倒风险。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the influencing factors of malnutrition in patients with Parkinson's disease (PD), and to observe the effects of malnutrition on frailty, cognitive function and fall risk. Methods: 100 patients with PD who were admitted to Jiangsu Provincial People's Hospital from March 2019 to March 2022 were selected. The nutritional status of the subjects was assessed using the Mini Nutrition Assessment (MNA), and 100 patients were divided into malnutrition group (n=52) and non-malnutrition group (n=48). Obtain general data of all patients, and the influencing factors of malnutrition in patients with PD were analyzed by Logistic regression. Frailty, cognitive function and fall risk were compared between the malnutrition group and non-malnutrition group. Results: Malnutrition in patients with PD was associated with age, body mass index, Hoehn-Yahr grade, residence, marital status, hemoglobin, albumin, prealbumin, daily levodopa equivalent dose (LEDDs), sleep status, anxiety status, depression status, taste disorder, swallowing disorder and decreased appetite(P<0.05). Logistic regression analysis showed that older age, Hoehn-Yahr grade III~V, deviation of sleep status, serious anxiety/depression status, taste disorder, swallowing disorder, decreased appetite and higher LEDDs were risk factors for malnutrition in patients with PD(P<0.05). The incidence of frailty in the malnutrition group was higher than that in the non-malnutrition group, and the incidence of pre-frailty and non-frailty was lower than those in the non-malnutrition group (P<0.05). The scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Scale (MOCA) in the malnutrition group were lower than those in the non-malnutrition group (P<0.05). The time of standing up and walking timing test (TUGT) and standing up test (CRT) in the malnutrition group were longer than those in the non-malnourished group, and the correct steps of walking straight gait test (TGT) were less than those in the non-malnutrition group(P<0.05). Conclusion: The risk of malnutrition in patients with PD is high, and it is affected by age, sleep status, anxiety status, depression status, Hoehn-Yahr grade, taste disorder, swallowing disorder, decreased appetite, LEDDs, and malnutrition can aggravate frailty, reduce cognitive function and increase the fall risk. |
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