| 敖思悦,陈 东,彭汉武,左 骑,肖 宝.定量脑电图联合PLR、NLR、MPV/PLT比值在急性脑梗死静脉溶栓治疗疗效和短期预后评估中的临床应用价值[J].现代生物医学进展英文版,2023,(16):3178-3182. |
| 定量脑电图联合PLR、NLR、MPV/PLT比值在急性脑梗死静脉溶栓治疗疗效和短期预后评估中的临床应用价值 |
| Clinical Application Value of Quantitative Electroencephalogram Combined with PLR, NLR, MPV/PLT Ratio in the Evaluation of Efficacy and Short-Term Prognosis of Intravenous Thrombolytic Therapy for Acute Cerebral Infarction |
| Received:January 13, 2023 Revised:February 07, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.16.035 |
| 中文关键词: 定量脑电图 PLR NLR MPV/PLT 急性脑梗死 静脉溶栓 治疗疗效 短期预后 评估价值 |
| 英文关键词: Quantitative electroencephalogram PLR NLR MPV/PLT Acute cerebral infarction Intravenous thrombolysis Therapeutic effect Short-term prognosis Application value |
| 基金项目:湖南省卫计委科研项目（B2016013） |
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| 中文摘要: |
| 摘要 目的：探究定量脑电图联合血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、血小板平均体积(MPV)/血小板计数(PLT)比值在急性脑梗死（ACI）静脉溶栓治疗疗效和短期预后评估中的临床应用价值。方法：选择2019年10月-2022年10月于长沙市第一医院收治的119例ACI患者为研究对象，根据静脉溶栓治疗疗效分为溶栓治疗有效组和溶栓治疗无效组，对比两组的功率比指数（DTABR）、PLR、NLR、MPV/PLT比值变化；根据ACI患者预后情况分为预后良好组与预后不良组，单因素分析比较两组基线临床资料，多因素Logistic回归模型分析ACI静脉溶栓预后影响因素，采用受试者工作特征曲线（ROC）分析各指标对ACI静脉溶栓预后的预测效能。结果：治疗后，溶栓治疗无效组DTABR、中性粒细胞计数、PLT、MPV、PLR、NLR、MPV/PLT比值显著高于溶栓治疗有效组（P＜0.05），淋巴细胞计数显著低于溶栓治疗有效组（P＜0.05）。与预后良好组比较，预后不良组年龄、入院时美国国立卫生院神经功能缺损评分(NIHSS)评分、溶栓24 h后NIHSS评分、高血压史占比、DTABR、中性粒细胞计数、PLT、MPV、PLR、NLR、MPV/PLT比值显著升高（P＜0.05），淋巴细胞计数显著降低（P＜0.05）。Logistic回归模型，显示入院时及溶栓24 h后NIHSS评分升高、DTABR升高、PLR升高、NLR升高、MPV/PLT比值升高是ACI静脉溶栓预后不良的危险因素（P＜0.05）。ROC曲线显示，DTABR、PLR、NLR、MPV/PLT比值联合预测ACI静脉溶栓预后的效能较高。结论：定量脑电图DTABR、PLR、NLR、MPV/PLT比值与ACI静脉溶栓治疗疗效和短期预后关系密切，对于短期预后有较高的预测价值。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the clinical application value of quantitative electroencephalogram combined with platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and mean platelet volume (MPV)/platelet count (PLT) ratio in the evaluation of efficacy and short-term prognosis of intravenous thrombolytic therapy for acute cerebral infarction (ACI). Methods: 119 patients with ACI who were admitted to Changsha First Hospital from October 2019 to October 2022 were selected as the study objects. According to the efficacy of intravenous thrombolytic therapy, they were divided into effective thrombolytic therapy group and ineffective thrombolytic therapy group.Compare the changes of power ratio index(DTABR), PLR, NLR, MPV/PLT ratio between the two groups. According to the prognosis of patients with ACI, they were divided into good prognosis group and poor prognosis group. Univariate analysis was performed to compare the baseline clinical data in the two groups. Multivariate Logistic regression model was used to analyze the influencing factors of prognosis of ACI intravenous thrombolysis. Receiver operating characteristic curve (ROC) was used to analyze the prognostic efficacy of each index for ACI intravenous thrombolysis. Results: After treatment, DTABR, neutrophilic granulocyte count, PLT, MPV, PLR, NLR and MPV/PLT ratio in the ineffective thrombolytic therapy group were significantly higher than those in the effective thrombolytic therapy group (P＜0.05), while the lymphocyte count was significantly lower than that in the effective thrombolytic therapy group (P＜0.05). Compared with the good prognosis group, the poor prognosis group was significantly increased in age, National Institutes of Health neurological deficit score (NIHSS) at admission, NIHSS score 24 h after thrombolysis, hypertension history ratio, DTABR, neutrophil count, PLT, MPV, PLR, NLR, and MPV/PLT ratio (P＜0.05), the lymphocyte count was significantly decreased (P＜0.05). Logistic regression model showed that increased NIHSS score at admission and 24 h after thrombolysis, increased DTABR, increased PLR, increased NLR and increased MPV/PLT ratio were risk factors for poor prognosis of ACI intravenous thrombolysis(P＜0.05). ROC curve showed that DTABR, PLR, NLR, MPV/PLT ratio combined to predict the prognosis of ACI intravenous thrombolysis was more effective. Conclusion: Quantitative electroencephalogram DTABR, PLR, NLR, MPV/PLT ratio are closely related to the efficacy and short-term prognosis of intravenous thrombolytic therapy for ACI, and which have high predictive value for short-term prognosis. |
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