| 吴晓玲,邹秋玉,郑莹芊,王 琼,单生涛,蔡 昫.电针夹脊穴联合化瘀通痹汤对老年2型糖尿病合并下肢动脉硬化闭塞症患者血清炎性因子、内皮功能及血液循环的影响[J].现代生物医学进展英文版,2023,(16):3133-3137. |
| 电针夹脊穴联合化瘀通痹汤对老年2型糖尿病合并下肢动脉硬化闭塞症患者血清炎性因子、内皮功能及血液循环的影响 |
| Effects of Electroacupuncture at Jiaji Point Combined with Huayu Tongbi Decoction on Serum Inflammatory Factors, Endothelial Function and Blood Circulation in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Lower Extremity Arteriosclerosis Obliterans |
| Received:December 27, 2022 Revised:January 24, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.16.026 |
| 中文关键词: 电针夹脊穴 化瘀通痹汤 老年 2型糖尿病 下肢动脉硬化闭塞症 炎性因子 内皮功能 血液循环 |
| 英文关键词: Electroacupuncture at Jiaji point Huayu Tongbi decoction Elderly Type 2 diabetes mellitus Lower extremity arteriosclerosis obliterans Inflammatory factors Endothelial function Blood circulation |
| 基金项目:湖南省临床医疗技术创新引导项目（2021SK51412） |
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| 中文摘要: |
| 摘要 目的：探讨电针夹脊穴联合化瘀通痹汤对老年2型糖尿病（T2DM）合并下肢动脉硬化闭塞症（ASO）患者血清炎性因子、内皮功能及血液循环的影响。方法：选取我院于2018年1月~2021年12月期间收治的98例老年T2DM合并ASO患者，按随机数表法分为对照组（49例，常规治疗+化瘀通痹汤治疗）、观察组（49例，常规治疗+电针夹脊穴联合化瘀通痹汤治疗），两组均治疗3周。对比两组患者疗效、胫后动脉和足背动脉血管峰值流速、血管内径及血流量、踝肱指数（ABI）、动脉硬化指数（AI）、白介素-6（IL-6）、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白介素-1（IL-1）、单核细胞趋化蛋白-1（MCP-1）、血管性假血友病因子（vWF）、一氧化氮（NO）、内皮素-1（ET-1）、空腹血糖。结果：观察组临床总有效率较对照组更高（P<0.05）。与对照组相比，观察组治疗3周后IL-6、CRP、TNF-α、IL-1均更低（P<0.05）。与对照组相比，观察组治疗3周后MCP-1、vWF、ET-1均更低，NO更高（P<0.05）。与对照组相比，观察组治疗3周后AI更低，ABI更高（P<0.05）。与对照组相比，观察组治疗3周后胫后动脉、足背动脉的血管峰值流速、血管内径、血流量更高（P<0.05）。两组治疗3周后空腹血糖均较治疗前下降，且观察组低于对照组（P<0.05）。结论：电针夹脊穴联合化瘀通痹汤治疗老年T2DM合并ASO患者，可控制患者血糖，改善内皮功能及血液循环，减轻机体炎性反应，提高临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of electroacupuncture at Jiaji point combined with Huayu Tongbi decoction on serum inflammatory factors, endothelial function and blood circulation in elderly patients with type 2 diabetes mellitus (T2DM) complicated with lower extremity arteriosclerosis obliterans (ASO). Methods: 98 cases of elderly patients with T2DM complicated with ASO who were admitted in our hospital from January 2018 to December 2021 were selected, they were divided into control group (49 cases, conventional treatment combined Huayu Tongbi decoction therapy), observation group (49 cases, conventional treatment combined electroacupuncture at Jiaji point combined with Huayu Tongbi decoction therapy) according to the random number table method, both groups were treated for 3 weeks. The efficacy, peak velocity of posterior tibial artery and dorsal pedal artery, vessel diameter and blood flow volume, ankle brachial index (ABI), arteriosclerosis index (AI), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), monocyte chemoattractant protein-1 (MCP-1), von willebrand factor (vWF), nitric oxide (NO), endothelin-1(ET-1), fasting blood glucose of patients in the two groups were compared. Results: The clinical total effective rate in the observation group was higher than that in the control group(P<0.05). Compared with the control group, the IL-6, CRP, TNF-α, IL-1 in the observation group at 3 weeks after treatment were lower (P<0.05). Compared with the control group, MCP-1, vWF, ET-1 in the observation group at 3 weeks after treatment were lower, NO was higher (P<0.05). Compared with the control group, AI in the observation group at 3 weeks after treatment was lower, ABI was higher(P<0.05). Compared with the control group, the peak velocity of posterior tibial artery and dorsal pedal artery, vessel diameter, blood flow volume in the observation group at 3 weeks after treatment were higher (P<0.05). The fasting blood glucose in the two groups at 3 weeks after treatment decreased compared with that before treatment, and the observation group was lower than the control group (P<0.05). Conclusion: Electroacupuncture at Jiaji point combined with Huayu Tongbi decoction in the treatment of elderly patients with T2DM complicated with ASO, it can control blood glucose of the patients, improve endothelial function and blood circulation, reduce the body's inflammatory response, which can improve clinical efficacy. |
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