| 王 枚,张玉婷,侯静雯,许慧娟,张 玲.血浆鸢尾素、生长分化因子-8在老年肌肉减少症患者中的表达及其诊断价值分析[J].现代生物医学进展英文版,2023,(15):2863-2867. |
| 血浆鸢尾素、生长分化因子-8在老年肌肉减少症患者中的表达及其诊断价值分析 |
| Expression and Diagnostic Value of Plasma Irisin and Growth Differentiation Factor-8 in Senile Patients with Sarcopenia |
| Received:December 12, 2022 Revised:December 31, 2022 |
| DOI：10.13241/j.cnki.pmb.2023.15.012 |
| 中文关键词: 老年 肌肉减少症 肌肉因子 鸢尾素 生长分化因子-8 诊断 |
| 英文关键词: Old age Sarcopenia Muscle factor Irisin Growth differentiation factor-8 Diagnosis |
| 基金项目:新疆维吾尔自治区自然科学基金项目（2021D01C432） |
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| 中文摘要: |
| 摘要 目的：分析血浆鸢尾素、生长分化因子-8在老年肌肉减少症患者中的表达及其诊断价值。方法：选择2020年4月至2022年4月在我院接受体检的620例老年体检者作为研究对象，其中238例肌肉减少症者作为观察组，382例非肌肉减少症者作为对照组。检测两组血浆鸢尾素、生长分化因子-8表达水平，观察血浆鸢尾素、生长分化因子-8在不同严重程度的老年肌肉减少症患者中差异性，使用Pearson相关性分析血浆鸢尾素、生长分化因子-8与全身骨骼肌质量、四肢骨骼肌质量、相对骨骼肌指数、握力和步速的关系，通过ROC下面积（AUC）评价血浆鸢尾素、生长分化因子-8对老年肌肉减少症的诊断效能。结果：观察组血浆鸢尾素表达水平低于对照组，生长分化因子-8表达水平高于对照组（P＜0.05）；肌肉减少症前期、肌肉减少症期、重度肌肉减少症期的患者血浆鸢尾素表达水平依次降低，生长分化因子-8表达水平依次升高（P＜0.05）；经Pearson相关性分析，老年肌肉减少症患者全身骨骼肌质量、四肢骨骼肌质量、相对骨骼肌指数、握力和步速均与子鸢尾素呈正相关(P＜0.05)，与生长分化因子-8呈负相关（P＜0.05）；经ROC曲线分析，血浆鸢尾素、生长分化因子-8诊断老年肌肉减少症的敏感度为78.49 %，特异度为90.67 %，AUC为0.914。结论：老年肌肉减少症患者血浆鸢尾素表达明显下调、生长分化因子-8表达明显上调，两者与病情严重程度密切相关，联合诊断此病的效能较好，值得临床予以重视应用。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression and diagnostic value of plasma irisin and growth differentiation factor-8 in elderly patients with sarcopenia. Methods: A total of 620 elderly patients who received physical examination in our hospital from April 2020 to April 2022 were selected as the study subjects, including 238 patients with sarcopenia as the observation group and 382 patients without sarcopenia as the control group. The expression levels of plasma irisin and growth differentiation factor-8 in the two groups were detected to observe the differences of plasma irisin and growth differentiation factor-8 in elderly patients with different degrees of sarcopenia. Pearson correlation was used to analyze the relationship between plasma irisin, growth differentiation factor-8 and total skeletal muscle mass, limb skeletal muscle mass, relative skeletal muscle index,grip strength and walking speed, and the diagnostic efficacy of plasma irisin and growth differentiation factor-8 in senile sarcopenia was evaluated by area under receiver operating characteristic curve (AUC). Results: The expression level of plasma irisin in the observation group was lower than that in the control group, and the expression level of growth differentiation factor-8 was higher than that in the control group (P<0.05). The expression level of plasma irisin in patients with pre-sarcopenia, sarcopenia and severe sarcopenia was decreased successively, and the expression level of growth differentiation factor-8 was increased successively (P<0.05). Pearson correlation analysis showed that body skeletal muscle mass,limb skeletal muscle mass, relative skeletal muscle index, grip strength and walking speed were positively correlated with irisin in senile sarcopenia patients (P<0.05), and negatively correlated with growth differentiation factor-8 (P<0.05). ROC curve analysis showed that the sensitivity, specificity and AUC of plasma irisin and growth differentiation factor-8 for the diagnosis of senility sarcopenia were 78.49 %,90.67 % and 0.914. Conclusion: The expression of plasma irisin and growth differentiation factor-8 in senile patients with sarcopenia is significantly down-regulated, which are closely related to the severity of the disease, the combined diagnosis of this disease is effective and worthy of clinical attention. |
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