| 叶佳伦,陈洁琼,王小山,叶 茂,陆桢兵,王艺沙,王仁颖.急性非ST段抬高型心肌梗死患者血清S100A4、S100A12与PCI术后预后的关系[J].现代生物医学进展英文版,2023,(14):2645-2649. |
| 急性非ST段抬高型心肌梗死患者血清S100A4、S100A12与PCI术后预后的关系 |
| Relationship between Serum S100A4, S100A12 and Prognosis after PCI in Patients with Acute Non-ST Segment Elevation Myocardial Infarction |
| Received:March 20, 2023 Revised:April 15, 2023 |
| DOI：10.13241/j.cnki.pmb.2023.14.008 |
| 中文关键词: 急性非ST段抬高型心肌梗死 S100A4 S100A12 经皮冠状动脉介入治疗 预后 |
| 英文关键词: Acute non-ST segment elevation myocardial infarction S100A4 S100A12 Percutaneous coronary intervention Prognosis |
| 基金项目:国家自然科学基金项目（81670352；81970327） |
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| 中文摘要: |
| 摘要 目的：探讨急性非ST段抬高型心肌梗死（ANSTEMI）患者血清S100钙结合蛋白A4（S100A4）、S100钙结合蛋白A12（S100A12）与经皮冠状动脉介入治疗（PCI）术后预后的关系。方法：选取2020年1月～2021年7月上海交通大学医学院附属瑞金医院急诊科收治的224例ANSTEMI患者为ANSTEMI组，PCI术后随访1年，根据预后情况分为预后不良组和预后良好组，另选取同期67名健康体检者为对照组。采用酶联免疫吸附法检测血清S100A4、S100A12水平。采用多因素Logistic回归分析 ANSTEMI患者PCI术后预后不良的影响因素，采用受试者工作特征（ROC）曲线分析血清S100A4、S100A12水平对ANSTEMI患者PCI术后预后不良的预测价值。结果：ANSTEMI组血清S100A4、S100A12水平高于对照组（P＜0.05）。随访1年，224例STEMI患者PCI术后预后不良发生率为16.07%（36/224）。多因素Logistic回归分析显示，年龄偏大、KILLIP分级≥Ⅱ级、S100A4、S100A12水平升高为ANSTEMI患者PCI术后预后不良的独立危险因素，左心室射血分数（LVEF）升高为其独立保护因素（P＜0.05）。ROC曲线分析显示，血清S100A4、S100A12水平联合预测ANSTEMI患者PCI术后预后不良的曲线下面积（AUC）大于S100A4、S100A12单独预测。结论：血清S100A4、S100A12水平升高与ANSTEMI患者PCI术后预后不良密切相关，血清S100A4、S100A12水平联合预测ANSTEMI患者PCI术后预后不良的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum S100 calcium-binding protein A4 (S100A4) and S100 calcium-binding protein A12 (S100A12) and prognosis after percutaneous coronary intervention (PCI) in patients with acute non-ST segment elevation myocardial infarction (ANSTEMI). Methods: 224 patients with ANSTEMI who were admitted to the Emergency Department of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2020 to July 2021 were selected as ANSTEMI group. After PCI, they were followed up for 1 year. They were divided into poor prognosis group and good prognosis group according to the prognosis, and 67 healthy subjects during the same period were selected as control group. Serum S100A4 and S100A12 levels were detected by enzyme-linked immunosorbent assay. Multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in patients with ANSTEMI after PCI, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of serum S100A4 and S100A12 levels for poor prognosis in patients with ANSTEMI after PCI. Results: Serum S100A4 and S100A12 levels in the ANSTEMI group were higher than those in the control group(P＜0.05). After 1-year follow-up, the incidence of poor prognosis after PCI in 224 patients with ANSTEMI was 16.07% (36/224). Multivariate Logistic regression analysis showed that older age, KILLIP grade≥Ⅱgrade, increased S100A4, S100A12 levels were independent risk factors for poor prognosis after PCI in patients with ANSTEMI, and increased left ventricular ejection fraction (LVEF) was independent protective factor(P＜0.05). ROC curve analysis showed that the area under the curve (AUC) of serum S100A4 and S100A12 combined predicted poor prognosis after PCI in patients with ANSTEMI was greater than that predicted by S100A4 and S100A12 alone(P＜0.05). Conclusion: Elevated serum S100A4 and S100A12 levels are closely associated with poor prognosis after PCI in patients with ANSTEMI, and the combined serum S100A4 and S100A12 levels has of high value in predicting poor prognosis after PCI in patients with ANSTEMI. |
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